Results 41 to 50 of about 1,593,998 (268)
Deregulation of KSHV latency conformation by ER-stress and caspase-dependent RAD21-cleavage. [PDF]
PLoS Pathogens, 2017 Kaposi's sarcoma (KS)-associated herpesvirus (KSHV) is a human gammaherpesvirus recognized as the principal causative agent of KS and primary effusion lymphoma (PEL).
Alessandra De Leo +3 more
doaj +1 more source
Detection of Short-Range Chromatin Interactions by Chromosome Conformation Capture (3C) in Yeast [PDF]
, 2014 We describe a modified 3C ("chromosome conformation capture") protocol for detection of transient, short-range chromatin interactions in the yeast Saccharomyces cerevisiae. 3C was initially described by Job Dekker and involves formaldehyde cross-linking to stabilize transient chromatin interactions, followed by restriction digestion, ligation, and ...
Badri Nath, Singh, Michael, Hampsey
openaire +2 more sources
A functional role for 4qA/B in the structural rearrangement of the 4q35 region and in the regulation of FRG1 and ANT1 in facioscapulohumeral dystrophy. [PDF]
PLoS ONE, 2008 The number of D4Z4 repeats in the subtelomeric region of chromosome 4q is strongly reduced in patients with Facio-Scapulo-Humeral Dystrophy (FSHD). We performed chromosome conformation capture (3C) analysis to document the interactions taking place among
Iryna Pirozhkova +5 more
doaj +1 more source
International Journal of Hematology-Oncology and Stem Cell Research, 2020 Background: Chromosomal breakpoints are the most common cause of hereditary diseases and cancers. Today, many standard clinical methods such as cytogenetic and PCR based techniques are used which have limitation regarding detection resolution. Chromosome
Moloud Absalan +7 more
doaj +1 more source
Wellcome Open Research, 2023 Background: Resolving causal genes for type 2 diabetes at loci implicated by genome-wide association studies (GWAS) requires integrating functional genomic data from relevant cell types.
Jason M. Torres +7 more
doaj +1 more source
Current Issues in Molecular Biology, 2023 Understanding the three-dimensional (3D) structure of chromatin is invaluable for researching how it functions. One way to gather this information is the chromosome conformation capture (3C) technique and its follow-up technique Hi-C.
David Vadnais, Oluwatosin Oluwadare
doaj +1 more source
Deciphering aging at three-dimensional genomic resolution
Cell Insight, 2022 Aging is characterized by progressive functional declines at the organismal, organic, and cellular levels and increased susceptibility to aging-related diseases.
Zunpeng Liu +4 more
doaj +1 more source
Randomized ligation control for chromosome conformation capture
, 2015 In experiments using chromosome conformation capture followed by PCR (3C-PCR) or chromosome conformation capture carbon copy (5C), it is critical to control for intrinsic biases in the restriction fragments of interest and the probes or primers used for ...
Dekker, Job, Belton, Jon-Matthew
core +1 more source
Cut-C: cleavage under tethered nuclease for conformational capture
BMC Genomics, 2019 Background Deciphering the 3D structure of the genome is essential for elucidating the regulatory mechanisms of gene expression in detail. Existing methods, such as chromosome conformation capture (3C) and Hi-C have enabled the identification of novel ...
Takashi Shimbo +5 more
doaj +1 more source
Chromosome Conformation Capture Carbon Copy (5C) in Budding Yeast
, 2015 Chromosome conformation capture carbon copy (5C) is a high-throughput method for detecting ligation products of interest in a chromosome conformation capture (3C) library.
Dekker, Job, Belton, Jon-Matthew
core +1 more source