Chromosome-level haplotype-resolved assembly of highly heterozygous grass genomes with PhaseGrass [PDF]
Nature CommunicationsCurrent methods to generate haplotype-resolved assemblies for highly heterozygous genomes suffer from reference bias when relying on reference-based phasing or may generate imbalanced haplomes when relying on graph-based phasing.
Yutang Chen +6 more
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A two-phase clustering procedure based on allele specific expression [PDF]
BMC BioinformaticsBackground Allele Specific Expression analysis is an important tool for integrating genome and transcriptome data. It quantifies expression variation between the two haplotypes of a diploid individual distinguished by heterozygous sites, and is a ...
Roberto Pagliarini +2 more
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A novel nucleoid-associated protein coordinates chromosome replication and chromosome partition [PDF]
Nucleic Acids Research, 2017 Patrick Viollier
exaly +2 more sources
Insights into the molecular mechanism of ParABS system in chromosome partition by HpParA and HpParB [PDF]
Nucleic Acids ResearchChwan-Deng Hsiao +2 more
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eLife, 2022 Three-component ParABS partition systems ensure stable inheritance of many bacterial chromosomes and low-copy-number plasmids. ParA localizes to the nucleoid through its ATP-dependent nonspecific DNA-binding activity, whereas centromere-like parS-DNA and
Andrea Volante +2 more
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The internal organization of mycobacterial partition assembly: does the DNA wrap a protein core? [PDF]
PLoS ONE, 2012 Before cell division in many bacteria, the ParBs spread on a large segment of DNA encompassing the origin-proximal parS site(s) to form the partition assembly that participates in chromosome segregation.
Shuo Qian +3 more
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Orderly Replication and Segregation of the Four Replicons of Burkholderia cenocepacia J2315. [PDF]
PLoS Genetics, 2016 Bacterial genomes typically consist of a single chromosome and, optionally, one or more plasmids. But whole-genome sequencing reveals about ten per-cent of them to be multipartite, with additional replicons which by size and indispensability are ...
Wen-Li Du +6 more
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Partition complex structure can arise from sliding and bridging of ParB dimers
Nature Communications, 2023 In many bacteria, chromosome segregation requires the association of ParB to the parS-containing centromeric region to form the partition complex. However, the structure and formation of this complex have been unclear.
Lara Connolley +3 more
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A discrete transition zone organizes the topological and regulatory autonomy of the adjacent tfap2c and bmp7 genes. [PDF]
PLoS Genetics, 2015 Despite the well-documented role of remote enhancers in controlling developmental gene expression, the mechanisms that allocate enhancers to genes are poorly characterized.
Taro Tsujimura +5 more
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The two Cis-acting sites, parS1 and oriC1, contribute to the longitudinal organisation of Vibrio cholerae chromosome I. [PDF]
PLoS Genetics, 2014 The segregation of bacterial chromosomes follows a precise choreography of spatial organisation. It is initiated by the bipolar migration of the sister copies of the replication origin (ori).
Ariane David +5 more
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