Results 51 to 60 of about 44,698 (271)

Partition of distinct chromosomal regions: negotiable border and fixed border [PDF]

Genes to Cells, 2004
Chromosomes are partitioned into distinct functional regions. For example, heterochromatin regions consist of condensed chromatin and contain few transcriptionally active genes, whereas euchromatin regions are less condensed and majority of active genes reside in the euchromatin regions.
Akatsuki, Kimura, Masami, Horikoshi
openaire   +2 more sources

Genetic Classification of Populations using Supervised Learning [PDF]

, 2010
There are many instances in genetics in which we wish to determine whether two candidate populations are distinguishable on the basis of their genetic structure.
A Motsinger-Reif, A Seretti, Aiden Corvin, B North, C Bailer-Jones, C Chang, Carlos Pinto, Colm O'Dushlaine, D Curtis, D Reich, D Reich, Daniel J. Kliebenstein, Derek Morris, E Jaynes, Elizabeth A. Heron, J Baik, J Baik, M Leshno, M Nelis, Michael Bridges, Michael Gill, N Patterson, O Lao, Ricardo Segurado, S Gull, S Penco, S Purcell   +26 more
core   +9 more sources

Bose-Einstein distribution, condensation transition and multiple stationary states in multiloci evolution of diploid population

, 2010
The mapping between genotype and phenotype is encoded in the complex web of epistatic interaction between genetic loci. In this rugged fitness landscape, recombination processes, which tend to increase variation in the population, compete with selection ...
A. Hartmann, C. Darwin, C. J. Pethick, D. Hartl, E. Ben-Naim, Ginestra Bianconi, J. H. Gillespie, J. Hofbauer, J. Monod, J. S. Yedidia, K. Huang, K. Jain, K. Sneppen, L. Peliti, M. A. Nowak, M. Mézard, Olaf Rotzschke, R. A. Fisher, U. Alon   +18 more
core   +1 more source

Targeting the chromosome partitioning protein ParA in tuberculosis drug discovery [PDF]

Journal of Antimicrobial Chemotherapy, 2010
To identify inhibitors of the essential chromosome partitioning protein ParA that are active against Mycobacterium tuberculosis.Antisense expression of the parA orthologue MSMEG_6939 was induced on the Mycobacterium smegmatis background. Screening of synthetic chemical libraries was performed to identify compounds with higher anti-mycobacterial ...
Nisa S, Blokpoel MCJ, Robertson BD, Tyndall JDA, Lun S, Bishai WR, O'Toole R   +6 more
openaire   +3 more sources

Combining chromosomal arm status and significantly aberrant genomic locations reveals new cancer subtypes [PDF]

, 2008
Many types of tumors exhibit chromosomal losses or gains, as well as local amplifications and deletions. Within any given tumor type, sample specific amplifications and deletionsare also observed.
Domany, Eytan, Hegi, Monika E., Lambiv, Wanyu L., Reiner, Anat, Shay, Tal   +4 more
core   +4 more sources

Chromosome partitioning in Escherichia coli: novel mutants producing anucleate cells [PDF]

Journal of Bacteriology, 1989
To study the chromosomal partitioning mechanism in cell division, we have isolated a novel type of Escherichia coli mutants which formed anucleate cells, by using newly developed techniques. One of them, named mukA1, is not lethal and produces normal-sized anucleate cells at a frequency of 0.5 to 3% of total cells in exponentially growing populations ...
S, Hiraga, H, Niki, T, Ogura, C, Ichinose, H, Mori, B, Ezaki, A, Jaffé   +6 more
openaire   +2 more sources

Coupling chromosome organization to genome segregation in Archaea

Nature Communications
Chromosome segregation is a fundamental process in all life forms and requires coordination with genome organization, replication and cell division. The mechanism that mediates chromosome segregation in archaea remains enigmatic.
Azhar F. Kabli, Irene W. Ng, Nicholas Read, Parul Pal, Julia Reimann, Ngat T. Tran, Sonja-Verena Albers, Tung B. K. Le, Daniela Barillà   +8 more
doaj   +1 more source

Explaining Adaptation in Genetic Algorithms With Uniform Crossover: The Hyperclimbing Hypothesis

, 2012
The hyperclimbing hypothesis is a hypothetical explanation for adaptation in genetic algorithms with uniform crossover (UGAs). Hyperclimbing is an intuitive, general-purpose, non-local search heuristic applicable to discrete product spaces with rugged or
Burjorjee, Keki M.
core   +2 more sources

Phylogeny and adaptive evolution of the brain-development gene microcephalin (MCPH1) in cetaceans. [PDF]

, 2011
BACKGROUND: Representatives of Cetacea have the greatest absolute brain size among animals, and the largest relative brain size aside from humans. Despite this, genes implicated in the evolution of large brain size in primates have yet to be surveyed in ...
Clark, Clay, Gatesy, John, McGowen, Michael R, Montgomery, Stephen H   +3 more
core   +6 more sources

An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots

FEBS Letters, EarlyView.
This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino, Meijie Li, Cécile Fizames, Mattia Adamo, Laurence Lejay, Christian Dubos, Matthieu Platre, Antoine Martin   +7 more
wiley   +1 more source