Results 61 to 70 of about 44,698 (271)

Mechanism of chromosome partitioning in Escherichia coli.

Seibutsu Butsuri, 1990
Replicated daughter chromosomes in Escherichia coli move nonprogressively and abruptly from midcell toward the quarter positions at the early D (division) period. The chromosome positioning is controlled by the mukA and mukB gene products. The mukA (tolC) gene encodes an outer membrane protein.
Sota HIRAGA, Hironori NIKI
openaire   +2 more sources

Characterization of a prokaryotic SMC protein involved in chromosome partitioning [PDF]

Genes & Development, 1998
smc of Bacillus subtilis encodes a homolog of eukaryotic SMC proteins involved in chromosome condensation, pairing, and partitioning. A null mutation in B. subtilis smc caused a temperature-sensitive-lethal phenotype in rich medium. Under permissive conditions, the mutant had abnormal nucleoids, approximately 10% of the cells were anucleate, and ...
R A, Britton, D C, Lin, A D, Grossman
openaire   +2 more sources

Segmentation of the Poisson and negative binomial rate models: a penalized estimator [PDF]

, 2013
We consider the segmentation problem of Poisson and negative binomial (i.e. overdispersed Poisson) rate distributions. In segmentation, an important issue remains the choice of the number of segments.
Cleynen, Alice, Lebarbier, Emilie
core   +2 more sources

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Chromosome partition in Escherichia coli requires postreplication protein synthesis

Journal of Bacteriology, 1989
After inhibition of protein synthesis, the number of nuclear bodies (nucleoids) visible in cells of Escherichia coli B/rA corresponded closely to the number of completely replicated chromosomes. We calculated that nucleoid partition follows almost immediately after replication forks reach the chromosome terminus.
W D, Donachie, K J, Begg
openaire   +3 more sources

Divide Precisely and Proliferate Safely: Lessons From Budding Yeast

Frontiers in Genetics, 2019
A faithful cell division is essential for proper cellular proliferation of all eukaryotic cells; indeed the correct segregation of the genetic material allows daughter cells to proceed into the cell cycle safely.
Roberta Fraschini
doaj   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

A conserved mechanism drives partition complex assembly on bacterial chromosomes and plasmids

Molecular Systems Biology, 2018
Chromosome and plasmid segregation in bacteria are mostly driven by ParABS systems. These DNA partitioning machineries rely on large nucleoprotein complexes assembled on centromere sites (parS).
Roxanne E Debaugny, Aurore Sanchez, Jérôme Rech, Delphine Labourdette, Jérôme Dorignac, Frédéric Geniet, John Palmeri, Andrea Parmeggiani, François Boudsocq, Véronique Anton Leberre, Jean‐Charles Walter, Jean‐Yves Bouet   +11 more
doaj   +1 more source

Copy Number Variants and Their Association With Intracerebral Hemorrhage Risk: A Case–Control Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Intracerebral Hemorrhage (ICH) is a leading cause of morbidity and mortality worldwide and lacks effective therapeutic interventions. Despite previous studies, the genetic underpinnings of ICH remain poorly understood. We sought to investigate the role of copy number variants (CNVs) in ICH pathophysiology to identify novel ...
Savvina Prapiadou, Carl D. Langefeld, Padmini Sekar, Mary Comeau, Timothy Howard, Tamara N. Kimball, Chen Bowang, Hyacinth I. Hyacinth, Jonathan Rosand, Christopher D. Anderson, Caspar Grond‐Ginsbach, Daniel Woo, Stacie L. Demel   +12 more
wiley   +1 more source

GIVE: portable genome browsers for personal websites. [PDF]

, 2018
Growing popularity and diversity of genomic data demand portable and versatile genome browsers. Here, we present an open source programming library called GIVE that facilitates the creation of personalized genome browsers without requiring a system ...
Alvin Zheng, B Sridhar, B Sridhar, C Tyner, D Barrios, D Comer, E Lieberman-Aiden, E Sharma, F Ozsolak, F Yue, FH Biase, JD Buenrostro, JG Aw, JT Robinson, LD Stein, ME Skinner, MJ Fullwood, Qiuyang Wu, R Bayer, R Li, R Mourad, S Carrere, Sheng Zhong, TC Nguyen, The ENCODE Project Consortium, VW Zhou, WJ Kent, X Li, X Zhou, Xiaoyi Cao, Z Lu, Zhangming Yan   +31 more
core   +2 more sources