Results 111 to 120 of about 178,325 (322)

The dynamics of signal amplification by macromolecular assemblies for the control of chromosome segregation [PDF]

, 2016
The control of chromosome segregation relies on the spindle assembly checkpoint (SAC), a complex regulatory system that ensures the high fidelity of chromosome segregation in higher organisms by delaying the onset of anaphase until each chromosome is ...
Bolanos-Garcia, Victor M., Lee, Semin
core   +1 more source

High‐Throughput Tiling of Essential mRNAs Increases Potency of Antisense Antibiotics

Advanced Science, EarlyView.
The systematic tiling of essential genes’ mRNA here presented, proposes a valuable tool for the identification of novel PNA sequences with antibiotic potential. The high‐throughput synthetic set up opens the door to investigating thousands of sequences in an economic way and ultimately identifies potent antisense oligonucleotides while also giving room
Giorgia Danti, Linda Popella, Jörg Vogel, Hans M. Maric   +3 more
wiley   +1 more source

Cdc14 and PP2A Phosphatases Cooperate to Shape Phosphoproteome Dynamics during Mitotic Exit

Cell Reports, 2019
Summary: Temporal control over protein phosphorylation and dephosphorylation is crucial for accurate chromosome segregation and for completion of the cell division cycle during exit from mitosis. In budding yeast, the Cdc14 phosphatase is thought to be a
Sandra A. Touati, Lorena Hofbauer, Andrew W. Jones, Ambrosius P. Snijders, Gavin Kelly, Frank Uhlmann   +5 more
doaj  

Insensitivity of Chromosome I and the Cell Cycle to Blockage of Replication and Segregation of Vibrio cholerae Chromosome II

mBio, 2012
Vibrio cholerae has two chromosomes (chrI and chrII) whose replication and segregation are under different genetic controls. The region covering the replication origin of chrI resembles that of the Escherichia coli chromosome, and both origins are under ...
Ryosuke Kadoya, Dhruba K. Chattoraj
doaj   +1 more source

Finding the middle ground: how kinetochores power chromosome congression [PDF]

, 2018
Genomic stability requires error-free chromosome segregation during mitosis. Chromosome congression to the spindle equator precedes chromosome segregation in anaphase and is a hallmark of metazoan mitosis.
Kops, Geert, Meraldi, Patrick, Saurin, Adrian   +2 more
core  

Mitigating Cell Cycle Effects in Multi‐Omics Data: Solutions and Analytical Frameworks

Advanced Science, EarlyView.
The study highlights the cell‐cycle effects on multi‐omics analysis attributed to varying cell cycle compositions across cell types. To minimize the influence, we propose RTD correction in CNV calling with a high S‐phase ratio, and phase comparison in chromatin accessibility, DNA methylation, and transcriptomics.
Rui Nie, Caihong Zheng, Likun Ren, Yue Teng, Yaoyu Sun, Lifei Wang, Junya Li, Jun Cai   +7 more
wiley   +1 more source

Loop-extruders alter bacterial chromosome topology to direct entropic forces for segregation

Nature Communications
Entropic forces have been argued to drive bacterial chromosome segregation during replication. In many bacterial species, however, specifically evolved mechanisms, such as loop-extruding SMC complexes and the ParABS origin segregation system, contribute ...
Janni Harju, Muriel C. F. van Teeseling, Chase P. Broedersz   +2 more
doaj   +1 more source

HIM-10 is required for kinetochore structure and function on Caenorhabditis elegans holocentric chromosomes. [PDF]

, 2001
Macromolecular structures called kinetochores attach and move chromosomes within the spindle during chromosome segregation. Using electron microscopy, we identified a structure on the holocentric mitotic and meiotic chromosomes of Caenorhabditis elegans ...
Albertson, Albertson, Albertson, Amon, Buchwitz, Dernburg, Fire, Gonczy, Harlow, Heald, Hedgecock, Hodgkin, Howman, Kainta, Kimble, Lombillo, Maney, McDonald, McEwen, Mello, Moore, Nabetani, Newman, Nicklas, O'Connell, Rappleye, Roos, Savoian, Shah, Sharp, Sharp, Wigge, Yanagida, Yao   +33 more
core   +2 more sources

Neonatally Lethal Fanconi Anemia due to an Amish Founder FANCE Gene Variant; Evidence for Genotype–Phenotype Correlation

American Journal of Medical Genetics Part A, Volume 197, Issue 7, July 2025.
ABSTRACT Prenatal and neonatal presentations of multiple congenital anomalies are difficult to diagnose and are associated with an increased risk of lethality. The differential diagnosis of antenatal presentations of radial ray malformations includes Fanconi anemia (FA), an inherited bone marrow failure disorder associated with congenital anomalies in ...
Ethan M. Scott, Olivia K. Wenger, Matthew Adams, Emma L. Baple, Andew Crosby, Joseph Leslie   +5 more
wiley   +1 more source

Mad2, Bub3, and Mps1 regulate chromosome segregation and mitotic synchrony in Giardia intestinalis, a binucleate protist lacking an anaphase-promoting complex. [PDF]

, 2014
The binucleate pathogen Giardia intestinalis is a highly divergent eukaryote with a semiopen mitosis, lacking an anaphase-promoting complex/cyclosome (APC/C) and many of the mitotic checkpoint complex (MCC) proteins.
Cande, W Zacheus, Vicente, Juan-Jesus
core   +2 more sources