Results 11 to 20 of about 178,325 (322)

Evolutionary dynamics of adult stem cells: Comparison of random and immortal strand segregation mechanisms [PDF]

, 2004
This paper develops a point-mutation model describing the evolutionary dynamics of a population of adult stem cells. Such a model may prove useful for quantitative studies of tissue aging and the emergence of cancer. We consider two modes of chromosome segregation: (1) Random segregation, where the daughter chromosomes of a given parent chromosome ...
A. T. Natarajan, C. S. Potten, D. Voet, J. R. Merok, T. Helleday   +4 more
arxiv   +3 more sources

Unique function of the bacterial chromosome segregation machinery in apically growing streptomyces - targeting the chromosome to new hyphal tubes and its anchorage at the tips [PDF]

PLoS Genetics, 2016
The coordination of chromosome segregation with cell growth is fundamental to the proliferation of any organism. In most unicellular bacteria, chromosome segregation is strictly coordinated with cell division and involves ParA that moves the ParB ...
Herron, Paul, Jakimowicz, Dagmara, Kois-Ostrowska, Agnieszka, Lipietta, Natalia, Strzałka, Agnieszka, Tilley, Emma, Zakrzewska-Czerwińska, Jolanta   +6 more
core   +5 more sources

Exotic mitotic mechanisms [PDF]

Open Biology, 2012
The emergence of eukaryotes around two billion years ago provided new challenges for the chromosome segregation machineries: the physical separation of multiple large and linear chromosomes from the microtubule-organizing centres by the nuclear envelope.
Drechsler, Hauke, McAinsh, Andrew D.
core   +3 more sources

Time scale of entropic segregation of flexible polymers in confinement: Implications for chromosome segregation in filamentous bacteria [PDF]

A. Arnold and S. Jun, Phys. Rev. E 76, 031901 (2007), 2007
We report molecular dynamics simulations of the segregation of two overlapping chains in cylindrical confinement. We find that the entropic repulsion between the chains can be sufficiently strong to cause segregation on a time scale that is short compared to the one for diffusion. This result implies that entropic driving forces are sufficiently strong
Axel Arnold, B. Alberts, Suckjoon Jun, T. A. J. Duke, T. Cremer   +4 more
arxiv   +3 more sources

Coordination of Chromosome Segregation and Cell Division in Staphylococcus aureus [PDF]

Frontiers in Microbiology, 2017
Productive bacterial cell division and survival of progeny requires tight coordination between chromosome segregation and cell division to ensure equal partitioning of DNA.
Adams, Arnaud, Bach, Ben-Yehuda, Bernhardt, Bi, Bisson-Filho, Bramkamp, Bramkamp, Britton, Brzoska, Bukau, Bukau, Busiek, Calloni, Claessen, Cooper, Cristea, Cristea, Daley, de Boer, Donovan, Donovan, Erickson, Fadda, Fleurie, Gatlin, Gregory, Gruber, Halbedel, Ireton, Ishikawa, Jensen, Karimova, Kato, Kloosterman, Kraemer, Landgraf, Lee, Lenarcic, Letek, Liew, Lutkenhaus, Marston, Minnen, Mohl, Novick, Oliva, Osawa, Patrick, Pereira, Pinho, Pinho, Pinho, Ramamurthi, Ramirez-Arcos, Rico, Schulz, Sieger, Singh, Steele, Sugimoto, Sullivan, Treuner-Lange, Turner, Tzagoloff, van Baarle, Varley, Veiga, Veiga, Willemse, Wu, Yang, Yu   +73 more
core   +5 more sources

A Brownian ratchet model for DNA loop extrusion by the cohesin complex

eLife, 2021
The cohesin complex topologically encircles DNA to promote sister chromatid cohesion. Alternatively, cohesin extrudes DNA loops, thought to reflect chromatin domain formation. Here, we propose a structure-based model explaining both activities.
Torahiko L Higashi, Georgii Pobegalov, Minzhe Tang, Maxim I Molodtsov, Frank Uhlmann   +4 more
doaj   +1 more source

Functional crosstalk between the cohesin loader and chromatin remodelers

Nature Communications, 2022
Chromatin remodelers direct the cohesin loader to nucleosome depleted regions where cohesin accesses chromosomes. Muñoz et al. now show that the cohesin loader in turn is a biochemical activator of a chromatin remodeler, helping to clear ...
Sofía Muñoz, Andrew Jones, Céline Bouchoux, Tegan Gilmore, Harshil Patel, Frank Uhlmann   +5 more
doaj   +1 more source

The large cytoplasmic volume of oocyte

The Journal of Reproduction and Development, 2022
The study of the size of cells and organelles has a long history, dating back to the 1600s when cells were defined. In particular, various methods have elucidated the size of the nucleus and the mitotic spindle in several species.
Hirohisa KYOGOKU, Tomoya S KITAJIMA
doaj   +1 more source

NuSAP4 regulates chromosome segregation in Trypanosoma brucei by promoting bipolar spindle assembly. [PDF]

Commun Biol
Faithful chromosome segregation in eukaryotes requires the assembly of a bipolar spindle and the faithful attachment of kinetochores to spindle microtubules, which are regulated by various spindle-associated proteins (SAPs) that play distinct functions ...
Zhou Q, Li Z.
europepmc   +2 more sources

Fission yeast condensin contributes to interphase chromatin organization and prevents transcription-coupled DNA damage

Genome Biology, 2020
Background Structural maintenance of chromosomes (SMC) complexes are central organizers of chromatin architecture throughout the cell cycle. The SMC family member condensin is best known for establishing long-range chromatin interactions in mitosis ...
Yasutaka Kakui, Christopher Barrington, David J. Barry, Tereza Gerguri, Xiao Fu, Paul A. Bates, Bhavin S. Khatri, Frank Uhlmann   +7 more
doaj   +1 more source