Results 11 to 20 of about 995,917 (290)
Role of the Number of Microtubules in Chromosome Segregation during Cell Division [PDF]
PLoS ONE 10(10): e0141305 (2015), 2015 Faithful segregation of genetic material during cell division requires alignment of chromosomes between two spindle poles and attachment of their kinetochores to each of the poles. Failure of these complex dynamical processes leads to chromosomal instability (CIN), a characteristic feature of several diseases including cancer.
Z. Bertalan +3 more
arxiv +3 more sources
Exotic mitotic mechanisms [PDF]
Open Biology, 2012 The emergence of eukaryotes around two billion years ago provided new challenges for the chromosome segregation machineries: the physical separation of multiple large and linear chromosomes from the microtubule-organizing centres by the nuclear envelope.
Hauke Drechsler, Andrew D. McAinsh
doaj +4 more sources
Cohesin and chromosome segregation [PDF]
Current Biology, 2018 Cohesin is a ring-shaped protein complex that organises the genome, enabling its condensation, expression, repair and transmission. Cohesin is best known for its role in chromosome segregation, where it provides the cohesion that is established between the two newly duplicated sister chromatids during S phase.
Makrantoni, Vasso, Marston, Adele L
core +4 more sources
Unique Function of the Bacterial Chromosome Segregation Machinery in Apically Growing Streptomyces - Targeting the Chromosome to New Hyphal Tubes and its Anchorage at the Tips. [PDF]
PLoS Genetics, 2016 The coordination of chromosome segregation with cell growth is fundamental to the proliferation of any organism. In most unicellular bacteria, chromosome segregation is strictly coordinated with cell division and involves ParA that moves the ParB ...
Agnieszka Kois-Ostrowska +6 more
doaj +5 more sources
Kinetochore component function in C. elegans oocytes revealed by 4D tracking of holocentric chromosomes [PDF]
Nature Communications, 2023 During cell division, chromosome congression to the spindle center, their orientation along the spindle long axis and alignment at the metaphase plate depend on interactions between spindle microtubules and kinetochores, and are pre-requisite for ...
Laras Pitayu-Nugroho +7 more
doaj +3 more sources
NuSAP4 regulates chromosome segregation in Trypanosoma brucei by promoting bipolar spindle assembly [PDF]
Communications BiologyFaithful chromosome segregation in eukaryotes requires the assembly of a bipolar spindle and the faithful attachment of kinetochores to spindle microtubules, which are regulated by various spindle-associated proteins (SAPs) that play distinct functions ...
Qing Zhou, Ziyin Li
doaj +2 more sources
Non-random Mis-segregation of Human Chromosomes [PDF]
Cell Reports, 2018 Summary: A common assumption is that human chromosomes carry equal chances of mis-segregation during compromised cell division. Human chromosomes vary in multiple parameters that might generate bias, but technological limitations have precluded a ...
Joseph Thomas Worrall +9 more
doaj +5 more sources
Nuclear Organization and Chromosome Segregation [PDF]
The Plant Cell, 1999 The genetic information underlying plant form and function is contained within the cell nucleus in the form of complex, dynamic DNA–protein structures—the chromosomes. The faithful transmission of these structures during mitosis and meiosis requires extensive chromosome reorganization and ...
A. E. Franklin, W. Zacheus Cande
openalex +4 more sources
Kinetochore-independent chromosome segregation driven by lateral microtubule bundles
eLife, 2015 During cell division, chromosomes attach to spindle microtubules at sites called kinetochores, and force generated at the kinetochore-microtubule interface is the main driver of chromosome movement.
Christina C Muscat +4 more
doaj +2 more sources
Mechanisms for Chromosome Segregation in Bacteria [PDF]
Frontiers in Microbiology, 2021 The process of DNA segregation, the redistribution of newly replicated genomic material to daughter cells, is a crucial step in the life cycle of all living systems. Here, we review DNA segregation in bacteria which evolved a variety of mechanisms for partitioning newly replicated DNA.
Gogou, C. (author) +2 more
openaire +6 more sources