Results 21 to 30 of about 995,917 (290)
Chromosome Segregation and Cancer
Experimental Cell Research, 1999 Sandra L Holloway +2 more
openalex +4 more sources
Nuclear chromosome locations dictate segregation error frequencies
Nature, 2022 Chromosome segregation errors during cell divisions generate aneuploidies and micronuclei, which can undergo extensive chromosomal rearrangements such as chromothripsis1–5. Selective pressures then shape distinct aneuploidy and rearrangement patterns—for
S. Klaasen +17 more
semanticscholar +1 more source
Functional crosstalk between the cohesin loader and chromatin remodelers
Nature Communications, 2022 Chromatin remodelers direct the cohesin loader to nucleosome depleted regions where cohesin accesses chromosomes. Muñoz et al. now show that the cohesin loader in turn is a biochemical activator of a chromatin remodeler, helping to clear ...
Sofía Muñoz +5 more
doaj +1 more source
A Brownian ratchet model for DNA loop extrusion by the cohesin complex
eLife, 2021 The cohesin complex topologically encircles DNA to promote sister chromatid cohesion. Alternatively, cohesin extrudes DNA loops, thought to reflect chromatin domain formation. Here, we propose a structure-based model explaining both activities.
Torahiko L Higashi +4 more
doaj +1 more source
The large cytoplasmic volume of oocyte
The Journal of Reproduction and Development, 2022 The study of the size of cells and organelles has a long history, dating back to the 1600s when cells were defined. In particular, various methods have elucidated the size of the nucleus and the mitotic spindle in several species.
Hirohisa KYOGOKU, Tomoya S KITAJIMA
doaj +1 more source
Theory of Active Intracellular Transport by DNA-relaying [PDF]
Phys. Rev. Lett. 127, 138101 (2021), 2021 The spatiotemporal organization of bacterial cells is crucial for the active segregation of replicating chromosomes. In several species, including Caulobacter crescentus, the ATPase ParA binds to DNA and forms a gradient along the long cell axis.
arxiv +1 more source
Spatially and temporally defined lysosomal leakage facilitates mitotic chromosome segregation
Nature Communications, 2020 Lysosomes are membrane-surrounded cytoplasmic organelles filled with a powerful cocktail of hydrolases. Besides degrading cellular constituents inside the lysosomal lumen, lysosomal hydrolases promote tissue remodeling when delivered to the extracellular
Saara Hämälistö +11 more
semanticscholar +1 more source
Budding yeast complete DNA synthesis after chromosome segregation begins
Nature Communications, 2020 To faithfully transmit genetic information, cells must replicate their entire genome before division. This is thought to be ensured by the temporal separation of replication and chromosome segregation.
Tsvetomira Ivanova +7 more
semanticscholar +1 more source
Chromosome segregation in Eubacteria [PDF]
Current Opinion in Microbiology, 2003 It is now clear that bacterial chromosomes rapidly separate in a manner independent of cell elongation, suggesting the existence of a mitotic apparatus in bacteria. Recent studies of bacterial cells reveal filamentous structures similar to the eukaryotic cytoskeleton, proteins that mediate polar chromosome anchoring during Bacillus subtilis sporulation,
Kit Pogliano +2 more
openaire +3 more sources
Genome Biology, 2020 Background Structural maintenance of chromosomes (SMC) complexes are central organizers of chromatin architecture throughout the cell cycle. The SMC family member condensin is best known for establishing long-range chromatin interactions in mitosis ...
Yasutaka Kakui +7 more
doaj +1 more source