Results 21 to 30 of about 178,125 (345)
A Brownian ratchet model for DNA loop extrusion by the cohesin complex
eLife, 2021 The cohesin complex topologically encircles DNA to promote sister chromatid cohesion. Alternatively, cohesin extrudes DNA loops, thought to reflect chromatin domain formation. Here, we propose a structure-based model explaining both activities.
Torahiko L Higashi +4 more
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Double-checking chromosome segregation. [PDF]
J Cell Biol, 2023 Enduring chromosome segregation errors represent potential threats to genomic stability due to eventual chromosome copy number alterations (aneuploidy) and formation of micronuclei—key intermediates of a rapid mutational process known as chromothripsis that is found in cancer and congenital disorders.
Maiato H, Silva S.
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The large cytoplasmic volume of oocyte
The Journal of Reproduction and Development, 2022 The study of the size of cells and organelles has a long history, dating back to the 1600s when cells were defined. In particular, various methods have elucidated the size of the nucleus and the mitotic spindle in several species.
Hirohisa KYOGOKU, Tomoya S KITAJIMA
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Chromosome segregation in Eubacteria [PDF]
Current Opinion in Microbiology, 2003 It is now clear that bacterial chromosomes rapidly separate in a manner independent of cell elongation, suggesting the existence of a mitotic apparatus in bacteria. Recent studies of bacterial cells reveal filamentous structures similar to the eukaryotic cytoskeleton, proteins that mediate polar chromosome anchoring during Bacillus subtilis sporulation,
Kit Pogliano +2 more
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Genome Biology, 2020 Background Structural maintenance of chromosomes (SMC) complexes are central organizers of chromatin architecture throughout the cell cycle. The SMC family member condensin is best known for establishing long-range chromatin interactions in mitosis ...
Yasutaka Kakui +7 more
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Developmental Cell, 2002 During mitosis, in most eukaryotes, cohesin is removed from chromosomes in two steps. A paper in the March issue of Molecular Cell identifies Polo-like kinase as a key regulator for the first step that releases much of cohesin during prophase.
Stefan Weitzer, Frank Uhlmann
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Nature Communications, 2020 Oocyte meiosis must achieve spindle bipolarization without predefined spatial cues. Yoshida et al. demonstrate that spindle bipolarization during meiosis I in mouse oocytes requires kinetochores to prevent chromosome segregation errors, a phenomenon that
Shuhei Yoshida +12 more
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Nuclear Organization and Chromosome Segregation [PDF]
The Plant Cell, 1999 The genetic information underlying plant form and function is contained within the cell nucleus in the form of complex, dynamic DNA–protein structures—the chromosomes. The faithful transmission of these structures during mitosis and meiosis requires extensive chromosome reorganization and ...
A. E. Franklin, W. Zacheus Cande
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SMC is recruited to oriC by ParB and promotes chromosome segregation in Streptococcus pneumoniae [PDF]
, 2011 Segregation of replicated chromosomes is an essential process in all organisms. How bacteria, such as the oval-shaped human pathogen Streptococcus pneumoniae, efficiently segregate their chromosomes is poorly understood.
Avery +61 more
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Current Opinion in Microbiology, 2001 The ability to visualise specific genes and proteins within bacterial cells is revolutionising knowledge of chromosome segregation. The essential elements appear to be the driving force behind DNA replication, which occurs at fixed cellular positions, the condensation of newly replicated DNA by a chromosome condensation machine located at the cell 1/4 ...
Sherratt, D, Lau, I, Barre, F
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