Results 21 to 30 of about 179,248 (347)

A global view of substrate phosphorylation and dephosphorylation during budding yeast mitotic exit

open access: yesMicrobial Cell, 2018
The cell cycle is the process by which a cell duplicates its DNA during S-phase and divides its chromosomes during M-phase, creating two genetically identical daughter cells.
Sandra A. Touati, Frank Uhlmann
doaj   +1 more source

Recombination and chromosome segregation

open access: yesPhilosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 2004
The duplication of DNA and faithful segregation of newly replicated chromosomes at cell division is frequently dependent on recombinational processes. The rebuilding of broken or stalled replication forks is universally dependent on homologous recombination proteins.
Sherratt, D   +6 more
openaire   +4 more sources

Chromosome Segregation: Disarming the Protector [PDF]

open access: yesCurrent Biology, 2013
One of the key features of meiosis is that shugoshin in complex with protein phosphatase 2A (PP2A) protects centromeric cohesin during meiosis I, but not during meiosis II. A new model suggests that a PP2A inhibitor mediates deprotection of centromeric cohesin during meiosis II.
Swastika Sanyal   +4 more
openaire   +3 more sources

Bacterial chromosome segregation

open access: yesFrontiers in Bioscience, 2012
Dividing cells have mechanisms to ensure that their genomes are faithfully segregated into daughter cells. In bacteria, the description of these mechanisms has been considerably improved in the recent years. This review focuses on the different aspects of bacterial chromosome segregation that can be understood thanks to the studies performed with model
Christophe Possoz   +2 more
openaire   +4 more sources

Errors in chromosome segregation during oogenesis and early embryogenesis [PDF]

open access: yes, 2010
Errors in chromosome segregation occurring during human oogenesis and early embryogenesis are very common. Meiotic chromosome development during oogenesis is subdivided into three distinct phases.
A Dyban   +65 more
core   +1 more source

Structure of the cohesin loader Scc2

open access: yesNature Communications, 2017
The cohesin complex maintains genome integrity by ensuring correct sister-chromatid segregation during mitosis and meiosis. Here, Chaoet al. present a pseudo-atomic model of the full-length Scc2–Scc4 cohesin loader complex and reveal key Scc2 surfaces ...
William C. H. Chao   +10 more
doaj   +1 more source

Bacterial chromosome segregation [PDF]

open access: yesMicrobiology, 2001
Recent years have witnessed a resurgence of interest in how the bacterial chromosome is organized and how newly replicated chromosomes are faithfully segregated into daughter cells on cell division. In the past, the problem with studying bacterial chromosomes was their lack of any obvious morphology, combined with the lack of ability to readily ...
openaire   +3 more sources

Prime movers : mechanochemistry of mitotic kinesins [PDF]

open access: yes, 2014
Mitotic spindles are self-organizing protein machines that harness teams of multiple force generators to drive chromosome segregation. Kinesins are key members of these force-generating teams.
A Blangy   +184 more
core   +1 more source

Securin Is Not Required for Chromosomal Stability in Human Cells [PDF]

open access: yes, 2005
Abnormalities of chromosome number are frequently observed in cancers. The mechanisms regulating chromosome segregation in human cells are therefore of great interest.
Azofeifa   +32 more
core   +4 more sources

Autism and mild epilepsy associated with a de novo missense pathogenic variant in the GTPase effector domain of DNM1

open access: yesAmerican Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView., 2023
Abstract Dynamin 1 is a GTPase protein involved in synaptic vesicle fission, which facilitates the exocytosis of neurotransmitters necessary for normal signaling. Pathogenic variants in the DNM1 gene are associated with intractable epilepsy, often manifested as infantile spasms at onset, developmental delay, and a movement disorder, and are located in ...
Davide Mei   +4 more
wiley   +1 more source

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