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Recombination and chromosome segregation
Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 2004 The duplication of DNA and faithful segregation of newly replicated chromosomes at cell division is frequently dependent on recombinational processes. The rebuilding of broken or stalled replication forks is universally dependent on homologous recombination proteins.
Sherratt, D +6 more
openaire +3 more sources
A simple biophysical model emulates budding yeast chromosome condensation
eLife, 2015 Mitotic chromosomes were one of the first cell biological structures to be described, yet their molecular architecture remains poorly understood. We have devised a simple biophysical model of a 300 kb-long nucleosome chain, the size of a budding yeast ...
Tammy MK Cheng +8 more
doaj +1 more source
Segregation but Not Replication of the
mBio, 2018 Coordination between chromosome replication and segregation is essential for equal partitioning of genetic material between daughter cells. In bacteria, this is achieved through the proximity of the origin of replication, oriC, and the chromosome ...
Bijit K. Bhowmik +3 more
doaj +1 more source
A surge of late-occurring meiotic double-strand breaks rescues synapsis abnormalities in spermatocytes of mice with hypomorphic expression of SPO11 [PDF]
, 2015 Meiosis is the biological process that, after a cycle of DNA replication, halves the cellular chromosome complement, leading to the formation of haploid gametes.
Barchi, Marco +9 more
core +3 more sources
Nature Communications, 2023 During cell division, chromosome congression to the spindle center, their orientation along the spindle long axis and alignment at the metaphase plate depend on interactions between spindle microtubules and kinetochores, and are pre-requisite for ...
Laras Pitayu-Nugroho +7 more
doaj +1 more source
American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView., 2023 Abstract Dynamin 1 is a GTPase protein involved in synaptic vesicle fission, which facilitates the exocytosis of neurotransmitters necessary for normal signaling. Pathogenic variants in the DNM1 gene are associated with intractable epilepsy, often manifested as infantile spasms at onset, developmental delay, and a movement disorder, and are located in ...
Davide Mei +4 more
wiley +1 more source
Spo0J and SMC are required for normal chromosome segregation in Staphylococcus aureus
MicrobiologyOpen, 2020 Bacterial chromosome segregation is an essential cellular process that is particularly elusive in spherical bacteria such as the opportunistic human pathogen Staphylococcus aureus.
Helena Chan +2 more
doaj +1 more source
Super-Resolution Mapping of Neuronal Circuitry With an Index-Optimized Clearing Agent
Cell Reports, 2016 Super-resolution imaging deep inside tissues has been challenging, as it is extremely sensitive to light scattering and spherical aberrations. Here, we report an optimized optical clearing agent for high-resolution fluorescence imaging (SeeDB2).
Meng-Tsen Ke +7 more
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A Cohesin-Based Partitioning Mechanism Revealed upon Transcriptional Inactivation of Centromere. [PDF]
PLoS Genetics, 2016 Transcriptional inactivation of the budding yeast centromere has been a widely used tool in studies of chromosome segregation and aneuploidy. In haploid cells when an essential chromosome contains a single conditionally inactivated centromere (GAL-CEN ...
Michael Tsabar +8 more
doaj +1 more source
The dynamics of signal amplification by macromolecular assemblies for the control of chromosome segregation [PDF]
, 2016 The control of chromosome segregation relies on the spindle assembly checkpoint (SAC), a complex regulatory system that ensures the high fidelity of chromosome segregation in higher organisms by delaying the onset of anaphase until each chromosome is ...
Bolanos-Garcia, Victor M., Lee, Semin
core +1 more source