Results 41 to 50 of about 101,933 (240)

A time out for CENP-A

Molecular & Cellular Oncology, 2017
Proper chromosome segregation relies on a functional centromere–kinetochore interface. We showed that chromatin containing CENtromere Protein A (CENP-A) is essential for centromere assembly, but dispensable for chromosome segregation in the presence of ...
S. Hoffmann, D. Fachinetti
doaj   +1 more source

Triazine‐Trione Thermosets with High Processability for Scaffold Applications in Bone Tissue Engineering

Advanced Healthcare Materials, EarlyView.
Novel photo‐clickable triazine‐trione thermosets can be shaped and cured under mild conditions, including room and physiological temperatures. These materials are biocompatible and support osteogenic differentiation of bone marrow–derived mesenchymal stem cells on their surface.
Åshild Johansen, Shuntaro Yamada, Daniel J. Hutchinson, Mohammed A. Yassin, Samih Mohamed‐Ahmed, Cecilie Gjerde, Michael Malkoch, Kamal Mustafa   +7 more
wiley   +1 more source

Fission yeast neddylation ligase Dcn1 facilitates cohesin cleavage and chromosome segregation at anaphase

Biology Open, 2017
Post-translational protein modification such as phosphorylation and ubiquitination are critical during mitosis to ensure proper timing and progression of chromosome segregation.
Lan Lin, Li Chen, Phong T. Tran
doaj   +1 more source

Elastic Energy Storage in Biological Materials: Internal Stresses and Their Functionality

Advanced Materials, EarlyView.
Harnessing and storing internally generated elastic energy is a clever strategy by biological materials to perform functions like shape transformation, movement, and predation. This review explores how biological systems manipulate mechanisms like atomic or protein integration into minerals, protein conformational shifts, phase transitions, and osmotic
Shahrouz Amini, Paul Zaslansky, Boaz Pokroy, Peter Fratzl   +3 more
wiley   +1 more source

Tension can directly suppress Aurora B kinase-triggered release of kinetochore-microtubule attachments

Nature Communications, 2022
Tension stabilizes properly attached microtubules to kinetochores during chromosome segregation, and lack of tension leads to release. Here the authors show that tension directly suppresses Aurora B kinase mediated destabilization of reconstituted ...
Anna K. de Regt, Cordell J. Clark, Charles L. Asbury, Sue Biggins   +3 more
doaj   +1 more source

Precision Diagnostics in Sports‐Related Traumatic Brain Injury: Pathophysiology, Biomarker Development and Emerging Technologies

Advanced Sensor Research, EarlyView.
Sports‐related traumatic brain injuries (TBIs) remain underdiagnosed, within amateur athletic cohorts. This review critically synthesises recent advancements in AI‐assisted neuroimaging, blood‐based biomarker profiling, wearable biosensing platforms for early detection, injury stratification, and longitudinal surveillance of TBIs.
Daniel Nicol, Mohamed T. Patel, Debarati Bhowmik, Pola Goldberg Oppenheimer   +3 more
wiley   +1 more source

Cell-Cycle Kinases Coordinate the Resolution of Recombination Intermediates with Chromosome Segregation

Cell Reports, 2013
Homologous recombination leads to the formation of DNA joint molecules (JMs) that must be resolved to allow chromosome segregation, but how resolution is temporally coupled with chromosome segregation is unknown.
Joao Matos, Miguel G. Blanco, Stephen C. West   +2 more
doaj   +1 more source

Exotic mitotic mechanisms [PDF]

Open Biology, 2012
The emergence of eukaryotes around two billion years ago provided new challenges for the chromosome segregation machineries: the physical separation of multiple large and linear chromosomes from the microtubule-organizing centres by the nuclear envelope.
Hauke Drechsler, Andrew D. McAinsh
doaj   +1 more source

The Mitochondrial Protein RESISTANCE to APHIDS 9 Interacts with S40 to Resist Aphid Infestation by Modulating Reactive Oxygen Species Homeostasis in Maize (Zea mays)

Advanced Science, EarlyView.
This study identifies the mitochondrial protein RTA9, a member of the Domain of Unknown Function 641 family, together with its partner S40, as key regulators of aphid resistance in maize. RTA9 promotes S40 degradation and modulates reactive oxygen species accumulation.
Chuanhong Wang, Xinqiao Zhang, Zhen Tao, Lei Wang, Shijie Huang, Tengyue Wang, Yibing Zhao, Jinghui Dong, Jing Ma, Chang Chang, Xingzhi Chen, Ning Lin, Peijin Li   +12 more
wiley   +1 more source

GSK461364 Inhibits NLRP3 Inflammasome by Targeting NEK7 Phosphorylation

Advanced Science, EarlyView.
Schematic diagram of the mechanism by which GSK461364 inhibits NLRP3 inflammasome activation. GSK461364 inhibits the phosphorylation of NEK7 likely at serine 221 and serine 260 by suppressing the activity of PLK1, thereby restraining the formation of the NLRP3 inflammasome.
Ruiheng Luo, Mingliang Ma, Dan Wang, Ling Luo, Xueming Xu, Lingmin Huang, Fupeng Wang, Guangyan Kuang, Huiqi Liu, Rui Ni, Xin Li, Qinghua Zhang, Shengfeng Wang, Kai Zhao   +13 more
wiley   +1 more source