Results 91 to 100 of about 5,203 (193)

Complex structural variation is prevalent and highly pathogenic in pediatric solid tumors

Cell Genomics
Summary: In pediatric cancer, structural variants (SVs) and copy-number alterations contribute to cancer initiation as well as progression, thereby aiding diagnosis and treatment stratification.
Ianthe A.E.M. van Belzen, Marc van Tuil, Shashi Badloe, Alex Janse, Eugène T.P. Verwiel, Marcel Santoso, Sam de Vos, John Baker-Hernandez, Hindrik H.D. Kerstens, Nienke Solleveld-Westerink, Michael T. Meister, Jarno Drost, Marry M. van den Heuvel-Eibrink, Johannes H.M. Merks, Jan J. Molenaar, Weng Chuan Peng, Bastiaan B.J. Tops, Frank C.P. Holstege, Patrick Kemmeren, Jayne Y. Hehir-Kwa   +19 more
doaj   +1 more source

Generation and maintenance of acentric stable double minutes from chromosome arms in inter-species hybrid cells

BMC Molecular and Cell Biology, 2019
Background Extrachromosomal acentric double minutes (DMs) contribute to human malignancy by carrying amplified oncogenes. Recent cancer genomics revealed that the pulverization of defined chromosome arms (chromothripsis) may generate DMs, however, nobody
Noriaki Shimizu, Rita Kapoor, Shuhei Naniwa, Naoto Sakamaru, Taku Yamada, You-ki Yamamura, Koh-ichi Utani   +6 more
doaj   +1 more source

Exploration of mechanisms for chromothripsis by irradiation.

, 2015
Chromothripsis is the massive but highly localized chromosome rearrangements within a one-step catastrophic event rather than a series of subsequent and random alterations.
Inazawa, Johji, 705531, 705530, 平井 百樹, 705528, 705527, Morishita, Maki, 705526, 數藤 由美子, 705525, Konishi, Teruaki, Hirai, Momoki, 705524, 705523, 705522, 705521, 705529, 小西 輝昭, Hayashi, Shin, Muramatsu, Tomoki, Moriyama, Keiji, Suto, Yumiko   +21 more
core  

Participation of retroelements in chromoanagenesis in cancer development

Сибирский онкологический журнал
Purpose of the study: to determine the role of retroelements in chromoanagenesis mechanisms in cancer etiopathogenesis.Material and Methods. The search for relevant sources was carried out in the Scopus, Web of Science, PubMed, Elibrary systems ...
R. N. Mustafin
doaj   +1 more source

Chromoanagenesis: cataclysms behind complex chromosomal rearrangements

Molecular Cytogenetics, 2019
Background During the last decade, genome sequencing projects in cancer genomes as well as in patients with congenital diseases and healthy individuals have led to the identification of new types of massive chromosomal rearrangements arising during ...
Franck Pellestor
doaj   +1 more source

Genomic Proximity Mapping for Identification of Chromosomal Aberrations in Multiple Myeloma

American Journal of Hematology, Volume 101, Issue 4, Page 899-903, April 2026.
Richard K. Kandasamy, Joel‐Sean Hsu, Steve Eacker, Hayley Mangelson, Zachary D. Stephens, Angela Dispenzieri, Esteban Braggio, P. Leif Bergsagel, Rafael Fonseca, S. Vincent Rajkumar, Shaji K. Kumar, Linda B. Baughn, Wilson I. Gonsalves, Akhilesh Pandey   +13 more
wiley   +1 more source

Breakpoint features of genomic rearrangements in neuroblastoma with unbalanced translocations and chromothripsis.

PLoS ONE, 2013
Neuroblastoma is a pediatric cancer of the peripheral nervous system in which structural chromosome aberrations are emblematic of aggressive tumors. In this study, we performed an in-depth analysis of somatic rearrangements in two neuroblastoma cell ...
Valentina Boeva, Stéphanie Jouannet, Romain Daveau, Valérie Combaret, Cécile Pierre-Eugène, Alex Cazes, Caroline Louis-Brennetot, Gudrun Schleiermacher, Sandrine Ferrand, Gaëlle Pierron, Alban Lermine, Thomas Rio Frio, Virginie Raynal, Gilles Vassal, Emmanuel Barillot, Olivier Delattre, Isabelle Janoueix-Lerosey   +16 more
doaj   +1 more source

Recurrent mutation of IGF signalling genes and distinct patterns of genomic rearrangement in osteosarcoma

Nature Communications, 2017
Osteosarcoma is a primary malignancy of bone that affects children and adults. Here, the authors sequence childhood and adult osteosarcomas, identifying mutations in insulin-like growth factor signalling genes and distinct genomic rearrangement profiles ...
Sam Behjati, Patrick S. Tarpey, Kerstin Haase, Hongtao Ye, Matthew D. Young, Ludmil B. Alexandrov, Sarah J. Farndon, Grace Collord, David C. Wedge, Inigo Martincorena, Susanna L. Cooke, Helen Davies, William Mifsud, Mathias Lidgren, Sancha Martin, Calli Latimer, Mark Maddison, Adam P. Butler, Jon W. Teague, Nischalan Pillay, Adam Shlien, Ultan McDermott, P. Andrew Futreal, Daniel Baumhoer, Olga Zaikova, Bodil Bjerkehagen, Ola Myklebost, M. Fernanda Amary, Roberto Tirabosco, Peter Van Loo, Michael R. Stratton, Adrienne M. Flanagan, Peter J. Campbell   +32 more
doaj   +1 more source

Supplementary Figure 2 from Chromothripsis in Human Breast Cancer

, 2020
Copy-number differences between cases with and without chromothripsis in the CATCH ...
Shaymaa Elgaafary (14945289), Hans-Peter Sinn (14945295), Steffen Hirsch (14913447), Markus Schulze (5173634), Verena Körber (14945286), Aurélie Ernst (686338), Marc Zapatka (14945307), Michiel Bolkestein (14945280), Frauke Devens (14945298), Peter Lichter (7440), Andreas Schneeweiss (14945304), John K.L. Wong (14945283), Felix K.F. Kommoss (14945292), Mario Hlevnjak (247206), Tobias Anzeneder (724335), Thomas Höfer (24033), Petra Schröter (14945301), Verena Thewes (14802146)   +17 more
core   +1 more source

Genomic instability, chromothripsis and cancer progression

, 2018
One of the biggest surprises to emerge from the cancer genome sequencing project has been the discovery of massively re-arranged genomes that have been detected within various types of human cancers caused by a novel mechanism called "chromothripsis ...
Gomes, Alexandra Galvão, Squire, Jeremy Andrew   +1 more
core