Results 101 to 110 of about 125,008 (257)

Idiopathic Intracranial Hypertension Is Characterized by a Distinct Proteomic Profile

Annals of Neurology, EarlyView.
Objectives The pathophysiology of idiopathic intracranial hypertension (IIH) is poorly understood and disease‐specific biomarkers are lacking. We aimed to shed light on IIH pathophysiology and identify disease‐specific biomarkers. Methods This prospective cross‐sectional cohort study included patients with new‐onset IIH and age‐, body mass index‐, and ...
Santosh D. Bhosale, Arkadiusz Nawrocki, Johanne J. Korsbæk, Nadja S. Hansen, Fabian Foettinger, Nik Krajnc, Mathias J. Norvig, Niclas L. Eriksen, Stefan Macher, Berthold Pemp, Connar S.J. Westgate, Christian B. Pedersen, Frantz R. Poulsen, Sune Munthe, Gabriel Bsteh, Martin R. Larsen, Rigmor H. Jensen, Dagmar Beier   +17 more
wiley   +1 more source

The interplay between molecular architecture, pharmacology, and suspected adverse drug reactions associated with nonsteroidal androgen antagonists in the United Kingdom

British Journal of Clinical Pharmacology, EarlyView.
Aims This work aimed to correlate potential links between the suspected adverse drug reaction (ADR) profile of licensed nonsteroidal androgen receptor antagonists (NSARA) with their unique chemical properties and known off‐target polypharmacology. Methods Physicochemical and polypharmacology data were curated from the Electronic Medicines Compendium ...
Simrit Dhillon, Albert A. Antolin, Alan M. Jones   +2 more
wiley   +1 more source

Empagliflozin demonstrates neuroprotective and cardioprotective effects by reducing ischemia/reperfusion damage in rat models of ischemic stroke and myocardial infarction

Scientific Reports
Sodium-glucose co-transporter 2 (SGLT2) inhibitors have demonstrated potential neuroprotective and cardioprotective effects in preliminary studies. This study evaluates the efficacy of empagliflozin (EMPA) in reducing ischemia/reperfusion damage in both ...
Wangde Dai, Rashid Alavi, Jiajun Li, Juan Carreno, Niema M. Pahlevan, Robert A. Kloner   +5 more
doaj   +1 more source

Cognitive reserve of patients with chronic cerebral ischemia

Bulletin of Russian State Medical University
Cognitive reserve (CR) is characterized by the ability to engage neural networks for adaptive reorganization of brain functions in response to damage or stress. This study aimed to identify the structural and functional organization of neural networks in patients with chronic cerebral ischemia (CCI) having different CR.
VF Fokin, NV Ponomareva, AA Shabalina, RN Konovalov, RB Medvedev, AI Boravova, OV Lagoda, MV Krotenkova, MM Tanashyan   +8 more
openaire   +1 more source

Effects of melatonin in experimental stroke models in acute, sub-acute, and chronic stages

Neuropsychiatric Disease and Treatment, 2009
Hsiao-Wen Lin, E-Jian LeeNeurophysiology Laboratory, Neurosurgical Service, Department of Surgery, National Cheng Kung University Medical Center and Medical School, Tainan, TaiwanAbstract: Melatonin (N-acetyl-5-methoxy-tryptamine), a naturally occurring ...
Hsiao-Wen Lin, E-Jian Lee
doaj  

Targeting neutrophil extracellular traps in metabolic and immune niche: Nanomaterials for diabetes tissue regeneration

BMEMat, EarlyView.
The effects of NETs on regeneration of various diabetic tissues, and strategies targeting NETs for diabetes tissue regeneration. In the diabetic environment, NETs undergo complex metabolic and immune reprogramming, leading to dynamic changes in antibacterial and proinflammatory functions, and affecting regeneration of multiple systemic tissues.
Xinyi Jiang, Muxin Yue, Kai Mao, Boon Chin Heng, Noor Azlin Yahya, Yunsong Liu, Zheng Li   +6 more
wiley   +1 more source

Atomically precise metal cluster enzymes for pathological tissue regeneration

BMEMat, EarlyView.
Schematic illustration of atomically precise metal cluster enzymes (MCEs) for pathological tissue regeneration. Atomically precise MCEs can modulate biological processes, such as attenuation of inflammatory responses, eradication of bacterial pathogens, regulation of angiogenesis, and promotion of cell development.
Ziqiang Xiong, Zhifeng Shi, Mengqing Li, Jien Han, Haoyan Chen, Maofei Ran, Shaojian Zhong, Limin Ma, Chengyun Ning, Youzhun Fan, Zhenghua Tang, Peng Yu   +11 more
wiley   +1 more source

Feasibility and Safety of Distal Transradial Access in Patients With Out‐of‐Hospital Cardiac Arrest Undergoing Emergency PCI: A Single‐Center Retrospective Study

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background Distal transradial access (dTRA) has gained attention for its lower risk of vascular complications compared to conventional transradial access (TRA). However, its feasibility and safety in patients with out‐of‐hospital cardiac arrest (OHCA) undergoing emergency percutaneous coronary intervention (PCI) remain uncertain.
Shiori Kawakami, Norimasa Taniguchi, Takeshi Yamada, Tetsuya Hata, Shunsuke Nakajima, Fumihiko Sano, Hideya Nakano, Mitusko Yokouchi, Aiko Ko, Akihiko Takahashi   +9 more
wiley   +1 more source

Cerebrovascular Events in Aortic Stenosis: From Native Valve Disease to TAVR‐Specific Risk and Prevention

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Aortic stenosis (AS) is associated with a heightened burden of cardiovascular comorbidities, atrial fibrillation (AF), and progressive valvular calcification, all of which may contribute to cerebrovascular events across the disease continuum.
Priyanka Boettger, Jamschid Sedighi, Martin Juenemann, Omar Alhaj‐Omar, Kerstin Piayda, Mani Arsalan, Samuel Sossalla, Won‐Keun Kim   +7 more
wiley   +1 more source

Features of cerebral hemodynamics and vascular autoregulation in chronic cerebral ischemia

Patologìâ, 2013
Обследовали 84 пациента, среди которых 62 больных дисциркуляторной энцефалопатией II стадии. Выделили 2 группы пациентов в зависмости от метода лечения: с (основная группа) и без (контрольная) применения L-аргинина. У пациентов исследовали церебральную гемодинамику путем проведения дуплексного сканирования экстра- и интракраниальных артерий. Полученные
Kozyolkin, O. A., Yarkova, S. V.
openaire   +2 more sources