Results 51 to 60 of about 2,897,650 (254)

Neurometabolic therapy in chronic cerebral ischemia

Lechaschi Vrach
Background. On February 10-12, 2025, the XXI Interdisciplinary Congress with international participation "Vein Readings" was held in Moscow. The congress is devoted to topical issues of neurology and every year successfully brings together leading specialists and scientists from near and far abroad.
V.D. Kovalev, M.V. Chirkova, E.Yu. Solovyeva   +2 more
openaire   +2 more sources

Cerebral Ischemia Due to Traumatic Carotid Artery Dissection: Case Report

, 2012
Blunt injury to the neck region may lead to carotid artery dissection and cerebral ischemia. Blunt injury to carotid artery is not frequent but determination of the presence of trauma in the history of stroke patients will provide early diagnosis and ...
Bahattin Hakyemez, Taşkapılıoğlu, Özlem, Deniz Kamacı Şener, Nermin Kelebek Girgin, Şener, Deniz Kamacı, Yakup Tomak, Hakyemez, Bahattin, Mustafa Bakar, Bakar, Mustafa, Girgin, Nermin Kelebek, Özlem Taşkapılıoğlu   +10 more
core   +1 more source

[18F]DPA-714: Direct Comparison with [11C]PK11195 in a Model of Cerebral Ischemia in Rats [PDF]

, 2013
Purpose: Neuroinflammation is involved in several brain disorders and can be monitored through expression of the translocator protein 18 kDa (TSPO) on activated microglia.
Banister, S D, Julyan, P, Rothwell, N J, Alison Smigova (281869), Galea, James, Cawthorne, Christopher, Wilkinson, S M, Christian Prenant (281864), Herholz, K; id_orcid, Renaud Maroy (281866), Herholz, Karl, Michael Kassiou, Wilkinson, Shane M, Peter Julyan (281871), Maroy, Renaud, Gavin Brown, Samuel D Banister, Boutin, Hervé, Banister, Samuel D, Greenhalgh, A D, Wilkinson, Shane M., Karl Herholz, Prenant, Christian, Karl Herholz (281875), Boutin, H, Hervé Boutin (281863), Michael Kassiou (281876), Hervé Boutin, Christopher Cawthorne, Rothwell, Nancy J., Brown, G, Nancy J. Rothwell (281877), Banister, Samuel D., Kassiou, M, James Galea (281867), Alison Smigova, Julyan, Peter, Brown, Gavin, Smigova, Alison, Smigova, A, Andrew D. Greenhalgh (281868), Gavin Brown (281874), James Galea, Kassiou, Michael, Rothwell, Nancy J, Christian Prenant, Samuel D. Banister (281873), Christopher Cawthorne (281870), Renaud Maroy, Maroy, R, Peter Julyan, Prenant, C, Greenhalgh, Andrew D., Greenhalgh, Andrew D, Shane M. Wilkinson (281872), Boutin, Hervé; id_orcid, Andrew D Greenhalgh, Cawthorne, C, Nancy J Rothwell, Galea, J, Shane M Wilkinson, Wilkinson Shane M., Rothwell, N, Banister Samuel D., Maroy Renaud, Greenhalgh, A, Banister, S, Prenant Christian, Herholz, K, Greenhalgh Andrew D., Herholz Karl, Julyan Peter, Julyan, Peter J, Galea James, Boutin Hervé, Smigova Alison, Wilkinson, S, Brown Gavin, Cawthorne Christopher, Kassiou Michael, Rothwell Nancy J.   +80 more
core   +1 more source

Microglial Deubiquitinase OTUD7B Stabilizes STAT3 to Promote Neuroinflammation and Cognitive Decline in Alzheimer's Disease

Advanced Science, EarlyView.
. ABSTRACT Neuroinflammation driven by microglial activation is a defining feature of Alzheimer's disease (AD), yet the molecular mechanisms sustaining this proinflammatory state remain unclear. Here, we identify the deubiquitinase OTUD7B as a critical regulator of microglial activation and AD pathology.
Luyao Li, Hao Tang, Qin Yu, Yuyang Zhang, Binglu Shi, Ying Kong, Leiyu Xu, Jingjing Shao, Chenghong Hu, Lingyu She, Zhe Wang, Haiyi Chen, Aleksandr V. Samorodov, Gang Cao, Xia Zhao, Yi Wang   +15 more
wiley   +1 more source

14‐3‐3γ Protects Against Postoperative Cognitive Dysfunction by Regulating Tau Thr205 Phosphorylation and Synaptic Integrity

Advanced Science, EarlyView.
Integrative multi‐cohort analyses identify 14‐3‐3γ as a biomarker and regulator of cognitive vulnerability. Experimental studies show that 14‐3‐3γ loss is associated with Tau Thr205 phosphorylation, synaptic dysfunction, and cognitive impairment, while genetic overexpression or pharmacological stabilization of 14‐3‐3γ confers protective effects in ...
Shouqiang Zhu, Xue Han, Heng Zhang, Chang Ye, Tianjiao Xia, Xiaoping Gu   +5 more
wiley   +1 more source

From the pathogenesis of chronic cerebral ischemia to targeted therapy [PDF]

Chronic progressive cerebrovascular pathology is a powerful disabling factor in modern society. Chronic cerebral ischemia is based on microcirculation and neuroinflammation problems, which are mutually potentiating pathogenetic aspects.
V. A. Mikhailov, Yu. V. Yarygina, D. V. Zakharov   +2 more
core   +1 more source

Nrsn1–Smarcc1 Coupling Regulates Neural Stem Cell Differentiation and Chronic‐phase Recovery After Ischemic Stroke

Advanced Science, EarlyView.
In the post‐stroke brain, Foxa2 induces the transcriptional upregulation of Nrsn1 in NSCs. Nrsn1 functionally couples with Smarcc1, modulating its nuclear availability and protein abundance, thereby influencing Smarcc1‐associated regulatory programs linked to neuronal lineage commitment. Through this coupling, Nrsn1 promotes the differentiation of NSCs
Ruolin Zhang, Chang Liu, Yuneng Zhou, Kaichen Zhao, Muyang Li, Bingcheng Cai, Ying Wang, Zhiyuan Yuan, Zhaoxin Liu, Zilong Yuan, Yao Xiao, Peiyang Zhou, Ke Shui, Wendai Bao, Min Zhang, Jun Qin, Jun Chen, Xin Yang, Zhiqiang Dong   +18 more
wiley   +1 more source

ROS‐Responsive Nanoparticle Delivery of Dexmedetomidine Protects the Gut Vascular Barrier After Intestinal Ischemia/Reperfusion via the HDAC‐H3K27ac‐TCF4 Axis

Advanced Science, EarlyView.
A low dose of dexmedetomidine, delivered by ROS‐responsive nanoparticles, preferentially accumulates in the ischemic intestine and restores gut vascular barrier integrity after ischemia/reperfusion injury. This nanoparticle‐based strategy prevents bacterial translocation and liver damage without cardiorespiratory side effects, working through HDAC ...
Hu‐Fei Zhang, Jian‐Tong Shen, Hua‐Hua Zhang, Si‐Qi Gao, Ji‐Ao Wang, Yue‐Ling Wang, Mei‐Ling Li, Zi‐Meng Liu, Yi‐Nan Zhang, Yan Li, Xu‐Yu Zhang   +10 more
wiley   +1 more source

Neuron‐Derived Vesicular circMagi1 Restrains Vascular Repair After Ischemic Stroke by Promoting TRIM65‐Mediated ANXA2 Degradation

Advanced Science, EarlyView.
After ischemic stroke, injured neurons transfer circMagi1 to endothelial cells through extracellular vesicles. Within endothelial cells, circMagi1 binds ANXA2 and enhances its engagement with TRIM65, promoting ANXA2 ubiquitination and proteasomal degradation to constrain angiogenic repair.
Youkun Bi, Qun Liu, Baohua Zou, Wenyuan Wang, Xinlong Qiao, Lin Gao, Chaoxu Miao, Ningning Huang, Shuqing Tang, Rui Guo, Changqing Zeng, Ce Jia, Yuanchao Xue, Xuejun Guo, Jianjun Chen, Huiwen Wang, Guangju Ji   +16 more
wiley   +1 more source

Differences in the evolution of the ischemic penumbra in stroke-prone spontaneously hypertensive and Wistar-Kyoto rats [PDF]

, 2009
<p><b>Background and Purpose:</b> Stroke-prone spontaneously hypertensive rats (SHRSP) are a highly pertinent stroke model with increased sensitivity to focal ischemia compared with the normotensive reference strain (Wistar-Kyoto rats ...
Dominiczak, Anna F., Graham, Delyth, Macrae, I. Mhairi, Gallagher, Lindsay, Gsell, Willy, McCabe, Christopher   +5 more
core   +1 more source