Results 61 to 70 of about 125,008 (257)

HMGB1 is a Potential Mediator of Astrocytic TLR4 Signaling Activation following Acute and Chronic Focal Cerebral Ischemia

Neurology Research International, 2020
Limited, and underutilized, therapeutic options for acute stroke require new approaches to treatment. One such potential approach involves better understanding of innate immune response to brain injury such as acute focal cerebral ischemia. This includes
Bolanle M. Famakin, Orest Tsymbalyuk, Natalia Tsymbalyuk, Svetlana Ivanova, Seung Kyoon Woo, Min Seong Kwon, Volodymyr Gerzanich, J. Marc Simard   +7 more
doaj   +1 more source

Functional Mapping of Neurodevelopmental Disease Pathways to Key Neurodevelopmental Processes Represented in the Developmental Neurotoxicity In Vitro Testing Battery

Advanced Science, EarlyView.
Human‐relevant methods are essential for modern chemical safety assessment. This study helps define the capabilities and boundaries of an in vitro testing battery for developmental neurotoxicity by exploring its biological applicability domain. By linking neurodevelopmental disease‐related pathways to key neurodevelopmental processes, the work enhances
Eliska Kuchovska, Kristina Bartmann, Georgea Raad, Mats Schade, Luiz Ladeira, Arif Dönmez, Jördis Klose, Nicolai Görts, Denis Polozij, Lynn‐Christin Saborowski, Farina Bendt, Bernard Staumont, Liesbet Geris, Katharina Koch, Ellen Fritsche   +14 more
wiley   +1 more source

MELDONIUM EFFICACY IN CHRONIC CEREBROVASCULAR DISEASES

Медицинский совет, 2016
The evidential base of meldonium in chronic cerebral ischemia is critically reviewed in the article.
M. A. DOMASHENKO, M. Yu. MAKSIMOVA
doaj   +1 more source

An Activity‐Dependent NEPAS–PTX3 Axis Links Neurovascular and Myelin Deficits to Cognitive Impairment

Advanced Science, EarlyView.
An activity‐dependent pathway links prefrontal circuit hypoactivity to cognitive impairment. Reduced PVA–mPFC activity upregulates NEPAS, which suppresses PTX3 secretion, leading to impaired angiogenesis, myelin deficits, and memory decline. Rescue is achieved by NEPAS knockdown or chemogenetic circuit activation.
Boya Hu, Zifei Chen, Bingmei Sun, Jiale Gao, Jiale Xu, Xiaochun Guo, Fenfei Gao, Zhongsi Wang, Jie Wu, Xiaoyu Ji, Peipei Liu, Bing Huang   +11 more
wiley   +1 more source

Chronic cerebral ischemia, neuroplasticity, possibilities of therapy

Неврология, нейропсихиатрия, психосоматика, 2017
The paper presents current views on the pathogenetic mechanisms of cerebral ischemia. It discusses the role of neurotrophins in the processes of neuroplasticity. Experimental and clinical studies of the neuropeptide drug Cerebrolysin are reviewed.
E. I. Chukanova, A. S. Chukanova
doaj   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

To the problems of modeling the brain ischemia in small animals

Journal of Education, Health and Sport, 2019
In the review article the problems of modeling cerebral ischemia in small mammals are consecrated. The advantages of experimental studies that are based on the similarity of the blood circulation of the brain in humans and animals are indicated ...
A. N. Stoyanov, S. S. Mashchenko, I. O. Ostapenko, I. K. Bakumenko, S. M. Oleinik, V. Z. Skorobreha   +5 more
doaj   +3 more sources

Comparison of the brain metabolism state, cognitive functions and life quality in patients with chronic brain ischemia

Актуальные проблемы теоретической и клинической медицины
Background: chronic cerebral ischemia is a common vascular pathology, the main etiopathogenetic mechanism of which is a progressive decrease in cerebral perfusion, leading to hypoxia of the nervous tissue and neuronal death.
M. L. Pospelova, D. V. Rijkova, T. M. Alekseeva, К. А. Samochernych, I. K. Ternovykh, A. A. Mihalicheva, V. V. Krasnikova, M. S. Voynov, E. E. Vyalykh, A. M. Makhanova   +9 more
doaj   +1 more source

Gasdermin D‐Mediated Release of IL‐33 Results in Fetal Brain Developmental Abnormalities During Maternal Colitis

Advanced Science, EarlyView.
Under colitis, Gsdmd mediates the release of IL‐33 from the epithelium of pregnant mice. IL‐33 can cross the placenta and enhance the proliferative capacity of neural stem cells, ultimately resulting in behavioral deficits in the offspring. Excessive pyroptosis in the colonic epithelium also triggers the translocation of LPS, which in turn increases ...
Huiyang Jia, Shukui Zhang, Kai Ma, Jie Zhou, Jianwei Jiao   +4 more
wiley   +1 more source

Treatment of comorbid patients with chronic brain ischemia and vertebrogenic pain syndromes

Медицинский совет, 2019
Chronic brain ischemia and chronic pain both appear to be an extremely wide-spread disease. The reasons of widespread comorbidity of ischemic brain disease and chronic pain are common risk factors: old age, decrease of physical activity, syndrome of ...
V. V. Zakharov, V. V. Grinyuk, N. V. Vakhnina, E. Yu. Kalimeeva   +3 more
doaj   +1 more source