Results 51 to 60 of about 1,319,691 (347)

Clustering of Major Cardiovascular Risk Factors and the Association with Unhealthy Lifestyles in the Chinese Adult Population. [PDF]

PLoS ONE, 2013
Previous studies indicated that lifestyle-related cardiovascular risk factors tend to be clustered in certain individuals. However, population-based studies, especially from developing countries with substantial economic heterogeneity, are extremely ...
Bixia Gao, Luxia Zhang, Haiyan Wang, China National Survey of Chronic Kidney Disease Working Group   +3 more
doaj   +1 more source

Predicting the Future Burden of Renal Replacement Therapy in Türkiye Using National Registry Data and Comparative Modeling Approaches

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic kidney disease is a growing public health problem worldwide, and the number of patients requiring renal replacement therapy is steadily increasing. Türkiye has experienced a similar rise in both the incidence and prevalence of renal replacement therapy over the past decades; however, national‐level projections of future ...
Arzu Akgül, Neriman Sıla Koç, Berrak Itır Aylı   +2 more
wiley   +1 more source

Humanized Mouse Models of Systemic Lupus Erythematosus: Opportunities and Challenges

Frontiers in Immunology, 2022
Animal models have played a crucial role in the understanding of the mechanisms and treatments of human diseases; however, owing to the large differences in genetic background and disease-specific characteristics, animal models cannot fully simulate the ...
Jiaxuan Chen, Shuzhen Liao, Huimin Zhou, Lawei Yang, Fengbiao Guo, Shuxian Chen, Aifen Li, Quanren Pan, Chen Yang, Hua-feng Liu, Qingjun Pan   +10 more
doaj   +1 more source

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Chronic kidney disease and cardiovascular risk in six regions of the world (ISN-KDDC): a cross-sectional study [PDF]

, 2016
Background Chronic kidney disease is an important cause of global mortality and morbidity. Data for epidemiological features of chronic kidney disease and its risk factors are limited for low-income and middle-income countries.
Bikbov, Boris, Carminati, Sergio, Ene-Iordache, Bogdan, Flores Bravo, Rodolfo, Islam, Nazmul, Perico, Norberto, Perna, Annalisa, Remuzzi, Andrea   +7 more
core  

Molecular Mechanisms of Kidney Injury and Repair in Arterial Hypertension [PDF]

, 2019
The global burden of chronic kidney disease is rising. The etiologies, heterogeneous, and arterial hypertension, are key factors contributing to the development and progression of chronic kidney disease. Arterial hypertension is induced and maintained by
Eckardt, Kai-Uwe, Sievers, Laura Katharina   +1 more
core   +2 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Combining mitochondrial proteomes and Mendelian randomization to identify novel therapeutic targets for diabetic nephropathy

Renal Failure
Diabetic nephropathy (DN) is a common microvascular complication of diabetes. Mitochondrial dysfunction in the kidney caused by diabetes has previously been linked to the pathogenesis of DN.
Yang Liu, Rong Wu, Zhelun Zhou, Junan Zhou, Jiaai Zhang, Xiaoyi Wang   +5 more
doaj   +1 more source

Research progress on endoplasmic reticulum homeostasis in kidney diseases

Cell Death and Disease, 2023
The endoplasmic reticulum (ER) plays important roles in biosynthetic and metabolic processes, including protein and lipid synthesis, Ca2+ homeostasis regulation, and subcellular organelle crosstalk. Dysregulation of ER homeostasis can cause toxic protein
Dan Wu, Li-Feng Huang, Xiao-Cui Chen, Xiao-Rong Huang, Hui-Yuan Li, Ning AN, Ji-Xin Tang, Hua-Feng Liu, Chen Yang   +8 more
doaj   +1 more source

Metformin improves renal injury of MRL/lpr lupus-prone mice via the AMPK/STAT3 pathway

Lupus Science and Medicine, 2022
Objective Lupus nephritis (LN) is a major complication and cause of death among patients with SLE. This research used in vivo and in vitro experiments to explore the therapeutic potential of metformin in kidney injury from LN-induced inflammation.Methods
Dan Wu, Chen Yang, Xiao-cui Chen, Hong-luan Wu, Hui-yuan Li, Hong-yong Su, Ze-jian Liu, Xiao-rong Huang, Xing Lu, Li-feng Huang, Shao-ping Zhu, Qing-jun Pan, Ning An, Hua-feng Liu   +13 more
doaj   +1 more source