Results 111 to 120 of about 95,190 (307)
Breaking barriers: the cGAS‐STING pathway as a novel frontier in cancer immunotherapy
Cancer Communications, EarlyView.Abstract Since its discovery, the cyclic GMP‐AMP synthase (cGAS)‐stimulator of the interferon gene (STING) signaling pathway has been considered a pivotal component of innate immunity and a promising target for cancer immunotherapy. Beyond its canonical role in pathogen defense, accumulating evidence has demonstrated that the cGAS‐STING pathway ...
Yuheng Yan +5 more
wiley +1 more source
Monoclonal immunoglobulin rescue from a patient with chronic lymphocytic leukemia and autoimmune hemolytic anemia [PDF]
, 1979 Karol Sikora, J Krikorian, Ronald Levy
openalex +1 more source
Partial Nuclear Extrusion in Chronic Lymphocytic Leukemia Observed to Be an In Vitro Artefact
American Journal of Hematology, EarlyView.
Rima Chatila +5 more
wiley +1 more source
Nanogel‐Mediated Immunotherapy to Tackle Cancer and Inflammatory Diseases
ChemistryEurope, EarlyView.Nanogels formed through self‐assembly, microemulsion, or precipitation polymerization method enable precise delivery of immunotherapeutic factors and immune cell targeting, thus effectively modulating immune responses. This review highlights recent advances in stimuli‐responsive nanogel design, underlying mechanisms, and their potentials to tackle ...
Ziwen Zhang +7 more
wiley +1 more source
Comparison of daily versus intermittent chlorambucil and prednisone therapy in the treatment of patients with chronic lymphocytic leukemia [PDF]
, 1977 A Sawitsky +3 more
openalex +1 more source
ChemMedChem, EarlyView.A partial proteolysis targeting chimera (PROTAC) library bearing achiral phenyl dihydrouracil cereblon ligands is prepared. It is then applied to the rapid development of a full PROTAC library targeting Bruton's tyrosine kinase, which can be directly used for screening.
Chelsi M. Almodóvar‐Rivera +5 more
wiley +1 more source
Increased Proportion of Complement-Receptor Lymphocytes in the Peripheral Blood of Patients With Chronic Lymphocytic Leukemia [PDF]
, 1972 Seth H. Pincus +2 more
openalex +1 more source
Drug Discovery Applications of Nitroso (Hetero)Arene Derivatives
ChemPlusChem, EarlyView.Nitroso (hetero)aromatic compounds are bioactive molecules with antiviral, anticancer, neuroprotective, and antimicrobial properties. This review highlights their mechanisms of action—oxidative stress, DNA damage, and enzyme inhibition—alongside synthesis, structure–activity relationships, and toxicity challenges, offering insight into their ...
Silvia Roscales, Aurelio G. Csáky
wiley +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.T‐cell engaging antibodies (TCEs) and chimeric antigen receptor (CAR) T cells (CAR‐T cells) are among precision medicine therapies that have revolutionized the treatment of hematologic cancers. Their success in oncology has piqued interest in translating this promise into additional indications, such as autoimmune disorders.
Peter Ashcroft +6 more
wiley +1 more source