Results 111 to 120 of about 281,573 (395)

Use of a hybrid intelligence decision tree to identify mature B‐cell neoplasms

Cytometry Part B: Clinical Cytometry, EarlyView., 2023
Abstract Background Mature B‐cell neoplasms are challenging to diagnose due to their heterogeneity and overlapping clinical and biological features. In this study, we present a new workflow strategy that leverages a large amount of flow cytometry data and an artificial intelligence approach to classify these neoplasms. Methods By combining mathematical
Inès Vergnolle, Theo Ceccomarini, Alban Canali, Jean‐Baptiste Rieu, François Vergez   +4 more
wiley   +1 more source

Highly similar genomic landscapes in monoclonal B-cell lymphocytosis and ultra-stable chronic lymphocytic leukemia with low frequency of driver mutations

Haematologica, 2018
Despite the recent discovery of recurrent driver mutations in chronic lymphocytic leukemia, the genetic factors involved in disease onset remain largely unknown.
Andreas Agathangelidis, Viktor Ljungström, Lydia Scarfò, Claudia Fazi, Maria Gounari, Tatjana Pandzic, Lesley-Ann Sutton, Kostas Stamatopoulos, Giovanni Tonon, Richard Rosenquist, Paolo Ghia   +10 more
doaj   +1 more source

Immunogenetics of chronic lymphocytic leukemia

Indian Journal of Pathology and Microbiology, 2017
Cytogenetic aberrations as well as presence of IGVH mutations are the underlying reason for clinical heterogeneity in Chronic Lymphocytic Leukemia (CLL). The presence of IGVH mutations as well as the predominant gene usage shows geographical variations. However, there is no study from India addressing immunogenetics of CLL.
Falguni Mishra, Hari Menon, Pratibha Amare Kadam, Shruti Chaudhary, Swapnali Joshi, Hasmukh Jain, Nikhil Patkar, P.G. Subramanian, Nikhil Rabade, Uma Dangi, Prashant Tembhare, Bhausaheb Bagal, Aditi Muranjan, Navin Khattry, Manju Sengar, Sumeet Gujral   +15 more
openaire   +4 more sources

Harnessing Photo‐Energy Conversion in Nanomaterials for Precision Theranostics

Advanced Materials, EarlyView.
Harnessing photo‐energy conversion in nanomaterials enables precision theranostics through light‐driven mechanisms such as photoluminescence, photothermal, photoelectric, photoacoustic, photo‐triggered surface‐enhanced Raman scattering (SERS), and photodynamic processes. This review explores six fundamental principles of photo‐energy conversion, recent
Jingyu Shi, Yadi Fan, Qin Zhang, Yingying Huang, Mo Yang   +4 more
wiley   +1 more source

Molecular and cytogenetic characterization of expanded B-cell clones from multiclonal versus monoclonal B-cell chronic lymphoproliferative disorders [PDF]

, 2014
Chronic antigen-stimulation has been recurrently involved in the earlier stages of monoclonal B-cell lymphocytosis, chronic lymphocytic leukemia and other B-cell chronic lymphoproliferative disorders.
Almeida, J.M.M. (Julia), Cortesão, E. (Emília), Criado, I. (Ignacio), González, M. (Marcos), Henriques, A. (Ana), Langerak, A.W. (Anton), Lecrevisse, Q. (Quentin), Nieto, W.G. (Wendy), Orfao, A. (Alberto), Paiva, A. (Artur), Rodríguez-Caballero, A. (Arancha)   +10 more
core   +4 more sources

Acquisition of the Recurrent Gly101Val Mutation in BCL2 Confers Resistance to Venetoclax in Patients with Progressive Chronic Lymphocytic Leukemia.

Cancer Discovery, 2018
The BCL2 inhibitor venetoclax induces high rates of durable remission in patients with previously treated chronic lymphocytic leukemia (CLL). However, despite continuous daily treatment, leukemia recurs in most patients.
P. Blombery, M. Anderson, Jia-Nan Gong, R. Thijssen, R. Birkinshaw, E. Thompson, Charis E. Teh, Tamia Nguyen, Zhen Xu, C. Flensburg, T. E. Lew, I. Majewski, D. Gray, D. Westerman, C. Tam, J. Seymour, P. Czabotar, D. Huang, A. Roberts   +18 more
semanticscholar   +1 more source

SnapShot: Chronic Lymphocytic Leukemia

Cancer Cell, 2014
Chronic lymphocytic leukemia (CLL) is the most common leukemia among adults in western countries. This SnapShot depicts the origins and evolution of this B cell malignancy, describes prognostic factors and CLL animal models, and illustrates therapies in preclinical and clinical development against CLL.
Alessandra Ferrajoli, Maria Ciccone, Michael J. Keating, George A. Calin   +3 more
openaire   +3 more sources

Advances and Strategies in Enhancing mRNA Cancer Vaccines

Advanced Materials, EarlyView.
Messenger RNA (mRNA) vaccines offer a powerful approach for cancer immunotherapy, but their clinical impact remains limited by delivery challenges and suboptimal immune activation. This review discusses key biological barriers and design strategies—including structural optimization, immunomodulation, organ targeting delivery, and advanced nanocarriers ...
Miao Zhang, Shengqi Chen, Haijun Hu, Yenhui Ong, Qianqian Ni   +4 more
wiley   +1 more source

Epigenetic evolution and lineage histories of chronic lymphocytic leukemia

Nature, 2019
Genetic and epigenetic intra-tumoral heterogeneity cooperate to shape the evolutionary course of cancer1. Chronic lymphocytic leukaemia (CLL) is a highly informative model for cancer evolution as it undergoes substantial genetic diversification and ...
Federico Gaiti, R. Chaligné, H. Gu, Ryan Brand, S. Kothen-Hill, Rafael C. Schulman, K. Grigorev, D. Risso, Kyu-Tae Kim, A. Pastore, Kevin Y. Huang, A. Alonso, Caroline Sheridan, Nathaniel D. Omans, Evan Biederstedt, Kendell Clement, Lili Wang, Joshua A. Felsenfeld, E. Bhavsar, Martin J. Aryee, J. Allan, R. Furman, A. Gnirke, Catherine J. Wu, A. Meissner, D. Landau   +25 more
semanticscholar   +1 more source

Advancing Clinical Medicine with Raman Spectroscopy: Current Trends and Future Perspectives

Advanced Photonics Research, EarlyView.
Raman spectroscopy and microscopy may become excellent tools in clinical medicine, including hematology, oncology, infectious diseases, neurology, gastroenterology, reproductive medicine, rheumatology, and cardiovascular research. However, many challenges such as signal interference, standardization issues, and limited clinical application need to be ...
Jiří Bufka, Lenka Vaňková, Josef Sýkora, Věra Křížková, Jan Schwarz, Petr Bouř   +5 more
wiley   +1 more source