Results 81 to 90 of about 82,620 (274)
Aggregate, EarlyView.Pathogen‐derived extracellular vesicle detection: theoretical insights and advanced methodologies: This review explores the theoretical foundations and practical applications of pEV detection, emphasizing the challenges and innovative strategies involving novel aggregate materials and machine learning for enhanced diagnostic accuracy.
Lihan Lai +6 more
wiley +1 more source
Haematologica, 2010 Background Bortezomib has been successfully used in the treatment of multiple myeloma and has been proposed as a potential treatment for chronic lymphocytic leukemia.
Maria Baou +9 more
doaj +1 more source
Enhancing Model Interpretability and Accuracy for Disease Progression Prediction via Phenotype-Based Patient Similarity Learning [PDF]
arXiv, 2019 Models have been proposed to extract temporal patterns from longitudinal electronic health records (EHR) for clinical predictive models. However, the common relations among patients (e.g., receiving the same medical treatments) were rarely considered.
arxiv
Haematologica, 2018 Despite the recent discovery of recurrent driver mutations in chronic lymphocytic leukemia, the genetic factors involved in disease onset remain largely unknown.
Andreas Agathangelidis +10 more
doaj +1 more source
Predicting Treatment Initiation from Clinical Time Series Data via Graph-Augmented Time-Sensitive Model [PDF]
arXiv, 2019 Many computational models were proposed to extract temporal patterns from clinical time series for each patient and among patient group for predictive healthcare. However, the common relations among patients (e.g., share the same doctor) were rarely considered. In this paper, we represent patients and clinicians relations by bipartite graphs addressing
arxiv
Hepatology, EarlyView., 2022 KAT7‐acetylated and cytoplasm‐translocated G‐protein GαS enhances IL‐6 effect and drives HCC progenitor cell progression. Abstract Background and Aims Hepatocarcinogenesis goes through HCC progenitor cells (HcPCs) to fully established HCC, and the mechanisms driving the development of HcPCs are still largely unknown.
Ye Zhou +15 more
wiley +1 more source
Hematological Oncology, Volume 40, Issue 5, Page 962-975, December 2022., 2022 Abstract Chronic lymphocytic leukemia (CLL) is a hematological disorder with complex clinical and biological behavior. TP53 mutational status and cytogenetic assessment of the deletion of the corresponding locus (17p13.1) are considered the most relevant biomarkers associated with pharmaco‐predictive response, chemo‐refractoriness, and worse prognosis ...
Giuseppa De Luca +19 more
wiley +1 more source
Journal of Medical Case Reports, 2018 Background Chronic lymphocytic leukemia and chronic myeloid leukemia are the most common types of adult leukemia. However, it is rare for the same patient to suffer from both.
Khadega A. Abuelgasim +6 more
doaj +1 more source
CLEAR: Coverage-based Limiting-cell Experiment Analysis for RNA-seq [PDF]
arXiv, 2018 Direct cDNA preamplification protocols developed for single-cell RNA-seq have enabled transcriptome profiling of precious clinical samples and rare cells without sample pooling or RNA extraction. Currently, there is no algorithm optimized to reveal and remove noisy transcripts in limiting-cell RNA-seq (lcRNA-seq) data for downstream analyses.
arxiv
Hematological Oncology, Volume 40, Issue 5, Page 876-884, December 2022., 2022 Abstract Adult T‐cell leukemia/lymphoma (ATL) patients have a very poor prognosis. The humanized anti‐CCR4 therapeutic monoclonal antibody, mogamulizumab, is a key agent for ATL treatment. Our previous integrated molecular analysis demonstrated that among all the driver genes in ATL, CCR7 gene alterations were significantly associated with clinical ...
Yuma Sakamoto +17 more
wiley +1 more source