Results 61 to 70 of about 2,366 (155)
Anti-diabetic Properties of Chrysophanol and Its Glucoside from Rhubarb Rhizome
Biological and Pharmaceutical Bulletin, 2008 An ethanol extract of rhubarb rhizome exhibited marked glucose transport activity in differentiated L6 rat myotubes. Activity-guided fractionation resulted in the isolation of two anthraquinones, chrysophanol-8-O-beta-D-glucopyranoside (1) and chrysophanol (2).
Myung Sun, Lee, Cheon Bae, Sohn
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Osteoarthritis: Mechanisms and Therapeutic Advances
MedComm, Volume 6, Issue 8, August 2025.A schematic illustration of the pathogenesis and emerging therapeutic strategies for OA, including: risk factors and molecular mechanisms of OA, joint changes between healthy and OA conditions, and current emerging therapeutic approaches for OA. Abbreviations: IA: intra‐articular injection; EVs: extracellular vesicles. ABSTRACT Osteoarthritis (OA) is a
Wei Liu +3 more
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Lipids in Health and Disease, 2019 Background Heat induced by infrared (IR) radiation from sun exposure increases skin temperature and can lead to thermal and photo-aging. However, little is known about the relationship between heat induced by IR radiation and lipid biosynthesis in human ...
Hyuk Chul Kwon +4 more
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Journal of Cellular and Molecular Medicine, Volume 29, Issue 15, August 2025.ABSTRACT This study aimed to investigate the anti‐tumour effect and the possible molecular mechanism of Tianma granules on colorectal cancer (CRC). The therapeutic effect of Tianma granules on CRC cell lines (HT116 and SW480) and AOM/DSS‐induced CRC mouse models was evaluated.
Renjing Lin +6 more
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Advanced Therapeutics, Volume 8, Issue 7, July 2025.Hispidulin disrupts the KITENIN/ErbB4 oncogenic complex and inhibits KITENIN‐mediated AP‐1 activity, cell invasion, and aerobic glycolysis. It also suppresses the production of cancer‐associated metabolites and downregulates transcriptional regulators downstream of the KITENIN complex.
Mücahit Varlı +7 more
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Iraqi Journal of Pharmaceutical Sciences, 2017 High performance liquid chromatography was applied for the separation and identification of four antharquinone derivatives, aloe emodin, emodin, chrysophanol and physcion. The separation was carried out using Eurospher 100, C18 column (4.6 mm i.d.
Alaadin M. Naqishbandi +2 more
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Hepatotoxicity and mechanism study of chrysophanol-8-O-glucoside in vitro
Biomedicine & Pharmacotherapy, 2019 To better understand the hepatotoxicity of anthraquinone glycosides, the hepatotoxicity of six anthraquinone glycosides was evaluated. The results show that chrysophanol-8-O-glucoside(C8G) has strong hepatotoxicity and can lead to increased LDH leakage and ROS, decreased GSH and MMP in L-02 hepatocytes.
Longfei, Lin +6 more
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Chrysophanol Inhibits the Progression of Diabetic Nephropathy via Inactivation of TGF-β Pathway
Drug Design, Development and Therapy, 2020 Chuan Guo,1,2 Yarong Wang,1 Yuanlin Piao,1 Xiangrong Rao,2 Dehai Yin1 1Department of Traditional Chinese Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Beijing 100730, People’s ...
Guo C, Wang Y, Piao Y, Rao X, Yin D
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Chrysophanol attenuates lead exposure-induced injury to hippocampal neurons in neonatal mice
Neural Regeneration Research, 2014 Previous studies have shown that chrysophanol protects against learning and memory impairments in lead-exposed adult mice. In the present study, we investigated whether chrysophanol can alleviate learning and memory dysfunction and hippocampal neuronal injury in lead-exposed neonatal mice.
Zhang, Ji +5 more
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Drug Design, Development and Therapy, 2020 Ting Ye,1,* Hua-Wu Gao,1,* Wei-Ting Xuan,1 Shu Ye,1– 3 Peng Zhou,1– 3 Xin-Quan Li,1 Yan Wang,1– 3 Hang Song,1,2 Yan-Yan Liu,1,2 Biao Cai1– 3 1School of Integrated Chinese and Western Medicine, Anhui University of Chinese Medicine,
Ye T +9 more
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