Results 11 to 20 of about 12,424 (198)

Adenovirus Disease Following Pediatric Liver Transplantation: 10-Year Experience From a Large Pediatric Transplant Program. [PDF]

Pediatr Transplant
The incidence of adenovirus disease is high (26%) after pediatric liver transplantation, with the majority of the infections occurring in the first 3 months post‐transplant highlighting the need for a high index of suspicion, early identification, and close follow‐up of adenovirus infection.
Banc-Husu AM, Hassan S, Galvan NTN, Moulton EA, Schraw JM, Hosek K, Cerminara D, Munoz FM, Mysore K.   +8 more
europepmc   +2 more sources

Targeting Genome Maintenance Defects of Cancers Using Chain-Terminating Nucleoside Analogs. [PDF]

Cancer Sci
Nucleoside analogs interfere with DNA replication either by their chain‐terminating properties or by serving as DNA damage on the template. The genome maintenance pathways required to maintain cellular tolerance to each nucleoside analog vary depending on the drug.
Kawasumi R, E Tabassum R, Hirota K.
europepmc   +2 more sources

Mpox in South Asia: A Narrative Review on Epidemiology, Preparedness, and Preventive Strategies. [PDF]

Health Sci Rep
ABSTRACT Background and Aims Monkeypox (Mpox), due to its growing global concern, was declared a public health emergency of worldwide concern by the World Health Organization in August 2024. The monkeypox virus (MPXV), once limited to African regions, has now spread to South Asia, including Pakistan, India, Nepal, and Sri Lanka, and there have been ...
Mawa J, Rimun SN, Rahman NZ, Bhuiyan MA, Shahriar M, Anjum R.   +5 more
europepmc   +2 more sources

Acyclovir-Resistant Herpes Simplex Virus in Pediatric Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplant: A Case Series. [PDF]

Transpl Infect Dis
This retrospective case series of acyclovir‐resistant HSV infection in pediatric patients undergoing allogeneic HSCT discusses the clinical course, associated complications, and treatment, including side effects. We propose the first algorithm for investigating and managing acyclovir‐resistant HSV infections in pediatric HSCT recipients, highlighting ...
Nunn J, Ahmed A, Senthil S, Mirci-Danicar O, Bonney D, Horgan C, Mustafa O, Wynn R, Guiver M, Nataraj R.   +9 more
europepmc   +2 more sources

Intralesional cidofovir for the treatment of recalcitrant periungual warts

Journal of Dermatological Treatment, 2023
Purpose: Successful treatment of periungual warts presents a clinical challenge, as many are refractory or represent following conventional treatments.
McKayla Poppens, Jeremy Davis
doaj   +1 more source

Antivirals against Monkeypox (Mpox) in Humans: An Updated Narrative Review

Life, 2023
As of 29 August 2023, a total of 89,596 confirmed cases of Mpox (monkeypox) have been documented across 114 countries worldwide, with 157 reported fatalities.
Giuseppe Bruno, Giovanni Battista Buccoliero   +1 more
doaj   +1 more source

Successful Treatment of Severe Adenoviral ARDS Using Cidofovir in a Case with Cerebral Palsy

Journal of Pediatric Emergency and Intensive Care Medicine, 2021
Adenovirus is a non-enveloped, double-stranded DNA virus that can cause infections in the upper and lower respiratory tract, conjunctiva, and gastrointestinal tract. Adenovirus infections are usually mild but may cause mortality and morbidity, especially
Emrah Gün, Tanıl Kendirli, Merve Havan, Serhan Özcan, Serdar Balsak, Edin Botan, Hatice Kübra Konca, Erdal İnce   +7 more
doaj   +1 more source

Current Drugs to Treat Infections with Herpes Simplex Viruses-1 and -2

Viruses, 2021
Herpes simplex viruses-1 and -2 (HSV-1 and -2) are two of the three human alphaherpesviruses that cause infections worldwide. Since both viruses can be acquired in the absence of visible signs and symptoms, yet still result in lifelong infection, it is ...
Lauren A. Sadowski, Rista Upadhyay, Zachary W. Greeley, Barry J. Margulies   +3 more
doaj   +1 more source

Adenovirus Infection in Hematopoietic and Solid Organ Paediatric Transplant Recipients: Treatment, Outcomes, and Use of Cidofovir

Microorganisms, 2023
Background: human adenovirus (hAdV) infection constitutes an important cause of morbidity and mortality in transplant recipients, due to their immune status. Among drugs currently available, cidofovir (CDF) is the most prescribed.
Carlos Grasa, Einés Monteagudo-Vilavedra, Elena Pérez-Arenas, Iker Falces-Romero, Yasmina Mozo del Castillo, Cristina Schüffelmann-Gutiérrez, Teresa del Rosal, Ana Méndez-Echevarría, Fernando Baquero-Artigao, Alejandro Zarauza Santoveña, Pilar Serrano Fernández, Talía Sainz, Cristina Calvo   +12 more
doaj   +1 more source

Ranpirnase (OKG-0301), a Novel Ribonuclease, Demonstrates Antiviral Activity against Adenovirus in the Ad5/NZW Rabbit Ocular Replication Model

Pathogens, 2022
Adenovirus ocular infections are common ocular viral infections seen worldwide, for which there is no approved antiviral therapy available. Ranpirnase is a novel ribonuclease which preferentially degrades tRNA resulting in an inhibition of protein ...
Eric G. Romanowski, Kathleen A. Yates, Eric J. Daniels, Brian M. Strem, John E. Romanowski, Regis P. Kowalski   +5 more
doaj   +1 more source