Results 51 to 60 of about 12,424 (198)
While providing potentially life‐saving cardiorespiratory support for critically ill patients, extracorporeal membrane oxygenation (ECMO) may detrimentally affect pharmacokinetic (PK) performance and concurrent drug efficacy and safety. We describe a patient with Pneumocystis jirovecii pneumonia (PJP) in the context of acquired immunodeficiency ...
Tom C. Zwart +7 more
wiley +1 more source
Historical Perspectives in the Development of Antiviral Agents Against Poxviruses
The poxvirus vaccinia virus (VV) served as the model virus for which the first antivirals, the thiosemicarbazones, were identified. This dates back to 1950; and, although there is at present no single antiviral drug specifically licensed for the ...
Erik De Clercq
doaj +1 more source
My collaboration with Prof. Antonín Holý, that spans a period of 3–4 decades (1976–2012), led to the discovery of several acyclic nucleoside phosphonates (ANPs) which were clinically developed by Gilead Sciences: cidofovir, adefovir, and tenofovir.
Erik De Clercq
doaj +1 more source
Maribavir for Cytomegalovirus Infection in High‐Risk Kidney Transplant Recipients: A Case Series
ABSTRACT Background Cytomegalovirus (CMV) infection remains a common complication after kidney transplantation, particularly among high‐risk donor‐seropositive/recipient‐seronegative (D+/R−) recipients. Valganciclovir is the standard first‐line therapy; however, its use may be limited by hematological toxicity or impaired graft function. Maribavir is a
Daiji Takamoto +6 more
wiley +1 more source
Antecedentes. La papilomatosis respiratoria recurrente es una afección viral rara y su tratamiento controvertido. Objetivo. Establecer la efectividad y seguridad del cidofovir como medicamento coadyuvante en el tratamiento de la papilomatosis ...
Gilberto Eduardo Marrugo Pardo +1 more
doaj
Airway Papillomatosis: New Treatments for an Old Challenge
Recurrent respiratory papillomatosis (RRP) is the recurrent growth of small, benign tumors, or papillomas, in the respiratory tract, caused by human papillomavirus (HPV). Currently, there is no cure.
Nankee Kumar +2 more
doaj +1 more source
HHV-6 in liver transplantation : A literature review [PDF]
Human herpesvirus 6 (HHV-6A and HHV-6B) can cause primary infection or reactivate from latency in liver transplant recipients, which can result in a variety of clinical syndromes, including fever, hepatitis, encephalitis and higher rates of graft ...
Lautenschlager, Irmeli +3 more
core +1 more source
ABSTRACT Human cytomegalovirus (HCMV) reactivation is a common and significant complication after allogeneic haematopoietic stem cell transplantation (allo‐HSCT), causing potentially life‐threatening disease. Antiviral therapy approaches for HCMV are often limited by toxicities and the risk of developing antiviral drug resistance.
Gaurav Sutrave +7 more
wiley +1 more source
ABSTRACT Objective To describe the clinical outcome of intravitreal cidofovir injection for palliative management of refractory end‐stage glaucoma and vision loss in silicone oil‐filled eyes following retinal reattachment surgery in dogs. Procedures Medical records of dogs that underwent a single intravitreal cidofovir injection for pharmacologic ...
Sunhyo Kim, Jaeho Shim
wiley +1 more source
Varicella-zoster virus infections in immunocompromised patients - a single centre 6-years analysis
Background Infection with varicella-zoster virus (VZV) contemporaneously with malignant disease or immunosuppression represents a particular challenge and requires individualized decisions and treatment.
Liese Johannes +8 more
doaj +1 more source

