Results 121 to 130 of about 21,394 (289)

Common themes in centriole and centrosome movements. [PDF]

, 2013
addresses: School of Life Sciences, Oxford Brookes University, Gipsy Lane, Oxford, OX3 0BP, UK.Copyright © 2011 Elsevier. NOTICE: this is the author’s version of a work that was accepted for publication in Trends in Cell Biology.
Allen, Basto, Beisson, Boisvieux-Ulrich, Boisvieux-Ulrich, Boisvieux-Ulrich, Bornens, Brugerolle, Burakov, Carreno, Chevrier, Cowan, Cowan, Dammermann, Dawe, Dawe, Dawe, Desai, Dupin, Etienne-Manneville, Etienne-Manneville, Euteneuer, Fan, Feldman, Finetti, Goldstein, Gomes, Gonczy, Gray, Griffiths, Griffiths, Gull, Helen R. Dawe, Higginbotham, Hirota, Hong, Jenkins, Jolly, Jolly, Karsenti, Kemphues, Kim, Klotz, Koonce, Kuhn, Kunda, Kunda, Lemullois, Lemullois, Lin, Ludford-Menting, Magdalena, Mahoney, Malone, Manneville, Moreira-Leite, Nejmeddine, Nigg, Palazzo, Pan, Park, Park, Pegtel, Piel, Piguet, Prigozhina, Raff, Riento, Rios, Robinson, Robinson, Rosenblatt, Roux, Ryser, Salpingidou, Schmoranzer, Scholey, Siegrist, Sonneville, Starr, Stinchcombe, Stinchcombe, Stowers, Sue Vaughan, Tabuse, Tanaka, Thery, Toyoshima, Tsai, Tsai, Tsou, Valente, Vaughan, Walczak, Wiedemann, Woolner, Worman, Wright, Yamashita, Zhang, Zhang, Zhen   +101 more
core   +1 more source

Disrupted alternative splicing for genes implicated in splicing and ciliogenesis causes PRPF31 retinitis pigmentosa

Nature Communications, 2018
Mutations in pre-mRNA processing factors (PRPFs) cause autosomal-dominant retinitis pigmentosa (RP), but it is unclear why mutations in ubiquitously expressed genes cause non-syndromic retinal disease.
A. Buskin, Lili Zhu, V. Chichagova, Basudha Basu, S. Mozaffari-Jovin, David Dolan, A. Droop, J. Collin, Revital Bronstein, Sudeep Mehrotra, M. Farkas, Gerrit Hilgen, K. White, K. Pan, A. Treumann, D. Hallam, K. Bialas, Git W. Chung, Carla B. Mellough, Yuchun Ding, N. Krasnogor, S. Przyborski, S. Zwolinski, J. Al-Aama, Sameer E. Alharthi, Yaobo Xu, G. Wheway, K. Szymanska, M. Mckibbin, C. Inglehearn, D. Elliott, S. Lindsay, R. Ali, D. Steel, L. Armstrong, E. Sernagor, H. Urlaub, E. Pierce, R. Lührmann, S. Grellscheid, Colin A. Johnson, M. Lako   +41 more
semanticscholar   +1 more source

MAPK15 Controls Hedgehog Signaling in Medulloblastoma Cells by Regulating Primary Ciliogenesis

Cancers, 2021
Simple Summary In eukaryotes, MAPK15 controls the assembly of primary cilia, which are microtubule-based cell surface organelles necessary for sensing and processing developmental signals as well as for transducing tumorigenic Hedgehog signaling in ...
Silvia Pietrobono, Lorenzo Franci, F. Imperatore, Cristina Zanini, B. Stecca, M. Chiariello   +5 more
semanticscholar   +1 more source

CRISPR‐Cas9‐Generated TXNDC15 c.560delA Homozygous Mouse Model Exhibits Meckel–Gruber Syndrome Phenotype

genesis, Volume 64, Issue 1, February 2026.
ABSTRACT To determine whether TXNDC15 variation causes Meckel–Gruber syndrome (MKS), we assessed the pathogenicity of the frameshift variant c.560delA. A CRISPR–Cas9 generated mouse model carrying the equivalent Txndc15 c.512delA mutation was analyzed at embryonic day 15.5.
Yang Liu, Hui Wang, Liyuan Chen, Xiaoxia Wu, Zhiyong Xu, Qingfa Huang, Hu Zhang, Xiushu Cao, Xinyuan Liang, Xingjian Zhong, Caiqun Luo   +10 more
wiley   +1 more source

Calibrated mitotic oscillator drives motile ciliogenesis

Science, 2017
Taming mitosis for differentiation The mitotic oscillator consists of molecular switches known to drive cell division forward. This conserved clocklike regulatory circuit has not previously been implicated in cellular processes other than division.
Al Jord, Adel, Shihavuddin, Asm, Servignat d’Aout, Raphaël, Faucourt, Marion, Genovesio, Auguste, Karaiskou, Anthi, Sobczak-Thépot, Joëlle, Spassky, Nathalie, Meunier, Alice   +8 more
openaire   +3 more sources

Matrix Metalloproteinase 7 Expression and Apical Epithelial Defects in Atp8b1 Mutant Mouse Model of Pulmonary Fibrosis

Biomolecules, 2022
Abnormalities in airway epithelia and lung parenchyma are found in Atp8b1 mutant mice, which develop pulmonary fibrosis after hyperoxic insult. Microarray and ingenuity pathway analysis (IPA) show numerous transcripts involved in ciliogenesis are ...
Emma Westermann-Clark, Ramani Soundararajan, Jutaro Fukumoto, Sahebgowda Sidramagowda Patil, Timothy M. Stearns, Smita Saji, Alexander Czachor, Helena Hernandez-Cuervo, Mason Breitzig, Sudarshan Krishnamurthy, Richard F. Lockey, Narasaiah Kolliputi   +11 more
doaj   +1 more source

Primary Cilia, Ciliogenesis and the Actin Cytoskeleton: A Little Less Resorption, A Little More Actin Please

Frontiers in Cell and Developmental Biology, 2020
Primary cilia are microtubule-based organelles that extend from the apical surface of most mammalian cells, forming when the basal body (derived from the mother centriole) docks at the apical cell membrane.
Claire E. L. Smith, Alice V. R. Lake, Colin A. Johnson   +2 more
semanticscholar   +1 more source

BAG3 is a negative regulator of ciliogenesis in glioblastoma and triple‐negative breast cancer cells

Journal of Cellular Biochemistry, 2021
By regulating several hallmarks of cancer, BAG3 exerts oncogenic functions in a wide variety of malignant diseases including glioblastoma (GBM) and triple‐negative breast cancer (TNBC).
B. Linder, Caterina Klein, Marina E. Hoffmann, F. Bonn, I. Dikič, D. Kögel   +5 more
semanticscholar   +1 more source

Multi‐Omics Revealed the Effects of Intrauterine Hyperglycemia Exposure on the Development of Skeletal Muscle in Offspring

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.
ABSTRACT Background Gestational diabetes mellitus (GDM), a common pregnancy complication characterized by maternal hyperglycemia, negatively impacts offspring health. Skeletal muscle, a critical tissue for glucose and lipid metabolism, is especially vulnerable to prenatal environmental insults.
Rui Liu, Junsen She, Xinyuan Li, Yishang Yan, Jiaying Mo, Jianzhong Sheng, Hongbo Yang, Hefeng Huang   +7 more
wiley   +1 more source

Missense Variants in the Second Transmembrane Domain of TMEM17 Disrupt Its Stability and Function and Lead to a Wide Phenotypic Spectrum of Ciliopathies

Clinical Genetics, Volume 109, Issue 2, Page 305-315, February 2026.
Missense variants in TMEM17 disrupt its localization and function at the ciliary transition zone, leading to a wide range of ciliopathy phenotypes, from OFD6 and Joubert syndromes to Meckel syndrome. ABSTRACT Ciliopathies are rare genetic disorders characterized by significant genetic and phenotypic variability.
Lucile Boutaud, Chunmei Li, Candice Moncler, Laure Verlin, Meriem Garfa‐Traoré, Nicolas Bourgon, Dhruvin Akbari, Jeanne Porée, Valentina Serpieri, Marine Panza, Lynda Haddad, Patrick Nitschké, Jacqueline Aziza, Cristina Matt, Enza Maria Valente, Patricia Gargallo, Charlotte Dubucs, Tania Attié‐Bitach, Michel R. Leroux, Sophie Thomas   +19 more
wiley   +1 more source