Results 121 to 130 of about 19,567 (308)

Mitonuclear Communication in Stem Cell Function

Cell Proliferation, EarlyView.
In this review, we highlight the critical functions of mitonuclear communication and its impact on mitochondrial proteostasis. Additionally, we examine how mitonuclear signalling influences stem cell function, offering new insights into cellular homeostasis, stem cell therapies, and the potential for lifespan extension.
Baozhou Peng, Yaning Wang, Hongbo Zhang
wiley   +1 more source

Essential role of Cenexin1, but not Odf2, in ciliogenesis [PDF]

Cell Cycle, 2013
Primary cilia are microtubule-based solitary sensing structures on the cell surface that play crucial roles in cell signaling and development. Abnormal ciliary function leads to various human genetic disorders, collectively known as ciliopathies.
Hyong Joo Lee, Bo Yeon Kim, Ki Won Lee, Jeong K. Bang, Sang Gwon Seo, Kyung S. Lee, Jung-Eun Park, Kyung Ho Lee, Jaerak Chang, Raymond L. Erikson, Kunio Nagashima   +10 more
openaire   +2 more sources

Ciliary transcription factors and miRNAs precisely regulate Cp110 levels required for ciliary adhesions and ciliogenesis

eLife, 2016
Upon cell cycle exit, centriole-to-basal body transition facilitates cilia formation. The centriolar protein Cp110 is a regulator of this process and cilia inhibitor, but its positive roles in ciliogenesis remain poorly understood.
Peter Walentek, Ian K Quigley, Dingyuan I Sun, Umeet K Sajjan, Christopher Kintner, Richard M Harland   +5 more
doaj   +1 more source

NRF2 and Primary Cilia: An Emerging Partnership

Antioxidants, 2020
When not dividing, many cell types target their centrosome to the plasma membrane, where it nucleates assembly of a primary cilium, an antenna-like signaling structure consisting of nine concentric microtubule pairs surrounded by membrane.
Ana Martin-Hurtado, Isabel Lastres-Becker, Antonio Cuadrado, Francesc R. Garcia-Gonzalo   +3 more
doaj   +1 more source

Ciliary IFT‐B Transportation Plays an Important Role in Human Endometrial Receptivity Establishment and is Disrupted in Recurrent Implantation Failure Patients

Cell Proliferation, EarlyView.
Our results suggested that mitochondria‐accelerated motile cilia intraflagellar transport may be involved in endometrial microenvironment establishment. ABSTRACT The lack of accurate understanding of cellular physiology and pathophysiology during the WOI constitutes the major obstacle to correct diagnosis and treatment for patients with recurrent ...
Haoxuan Yang, Jing Zhang, Fei Yan, Yihong Chen, Yang Wu, Jiaxin Luo, Lian Duan, Juan Zou, Juncen Guo, Jiyun Pang, Andras Dinnyes, Jiuzhi Zeng, Weixin Liu, Chi Chiu Wang, Yi Lin, Xue Xiao, Xiaomiao Zhao, Wenming Xu   +17 more
wiley   +1 more source

The IN/OUT assay: a new tool to study ciliogenesis [PDF]

Cilia, 2016
Nearly all cells have a primary cilia on their surface, which functions as a cellular antennae. Primary cilia assembly begins intracellularly and eventually emerges extracellularly. However, current ciliogenesis assays, which detect cilia length and number, do not monitor ciliary stages.We developed a new assay that detects antibody access to a ...
Derek Toomre, Felix Rivera-Molina, Ira Kukic   +2 more
openaire   +2 more sources

FGF2 is expressed in human and murine embryonic choroid plexus and affects choroid plexus cell behaviour [PDF]

, 2008
Background Although fibroblast growth factor (Fgf) signalling plays crucial roles in several developing and mature tissues, little information is currently available on expression of Fgf2 during early choroid plexus development and whether Fgf2 directly ...
Ferretti, P., Greenwood, S., Swetloff, A., Terasaki, T., Wade, A.   +4 more
core   +3 more sources

Mitochondrial control of ciliary gene expression and structure in striatal neurons

The Journal of Physiology, EarlyView.
Abstract figure legend Neurons drive animal behaviour by receiving and transmitting information and require energy, primarily supplied by mitochondria, to function. Additionally, neurons need to sense environmental changes to adapt, a function that is locally played by the primary cilia.
Dogukan H. Ulgen, Alessandro Chioino, Olivia Zanoletti, Albert Quintana, Elisenda Sanz, Carmen Sandi   +5 more
wiley   +1 more source

Prostaglandin signalling regulates ciliogenesis by modulating intraflagellar transport [PDF]

, 2014
Cilia are microtubule-based organelles that mediate signal transduction in a variety of tissues. Despite their importance, the signalling cascades that regulate cilium formation remain incompletely understood. Here we report that prostaglandin signalling
A Becker-Heck, A Caron, AG Kramer-Zucker, AJ Slot, AM Lord, Anna Papierniak, AS Bogard, B Sarmah, B St-Jacques, BD Engel, Bin Zhou, BR Haxel, C Williams, CD Loftin, Chin Chiang, Daqing Jin, FG Russel, G Conseil, G Reid, GA Gross, Guangju Yu, Gwenaëlle Conseil, H Higginbotham, H Youk, Haiyan Wan, Iain A. Drummond, J Cao, J Reese, JA Boyce, Jarema Malicki, JD Amack, JD Schuetz, JE Dinchuk, Jeffrey D. Amack, Jianjian Sun, JJ Essner, JL Stubbs, JM Gerdes, JM Neugebauer, John D. Schuetz, Jonathan Fleming, JW Regan, M Fliegauf, M Leggas, M Tsujikawa, M Westerfield, MT Hoque, MV Nachury, PV Tran, R Langenbach, RJ Starner, S Long, S Narumiya, S Schuldiner, Satish Cheepala, SC Goetz, SC Goetz, SS Lopes, Susan P. C. Cole, Tao P. Zhong, TE North, Terri T. Ni, TP Zhong, TP Zhong, TY Besschetnova, W Driever, W Goessling, Wenyan Li, WL Smith, X Pan, X Yu, Y Fukuda, Y Omori, YI Cha, YI Cha, Z Wang   +75 more
core   +1 more source

Elucidating the Molecular Landscape of Cystic Kidney Disease: Old Friends, New Friends and Some Surprises

American Journal of Medical Genetics Part A, Volume 197, Issue 6, June 2025.
ABSTRACT Cystic kidney diseases (CyKD) are a diverse group of disorders affecting more than 1 in 1000 individuals. Over 120 genes are implicated, primarily encoding components of the primary cilium, transcription factors, and morphogens. Prognosis varies greatly by molecular diagnosis. Causal variants are not identified in 10%–60% of individuals due to
Deborah Watson, Frank Mentch, Jonathan Billings, Kayleigh Ostberg, Michael E. March, Jennifer M. Kalish, Dong Li, India Cannon, Lisa M. Guay‐Woodford, Erum Hartung, Alanna Strong   +10 more
wiley   +1 more source