Results 11 to 20 of about 22,114 (247)
Cilium incarnatum externum [PDF]
Digital Journal of Ophthalmology, 2017 A 25-year-old woman presented with a history of a cosmetically bothersome bulge over her left eyelid. She was diagnosed with cilium incarnatum externum. The subcutaneous cilium was surgically removed and examined.
Taru, Dewan +4 more
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The chondrocyte primary cilium [PDF]
Osteoarthritis and Cartilage, 2014 The presence and role of primary, or non-motile, cilia on chondrocytes has confused cartilage researchers for decades. Initial explanations attributed a vestigial nature to chondrocyte cilia. Evidence is now emerging that supports the role of the chondrocyte primary cilium as a sensory organelle, in particular, in mechanotransduction and as a ...
Ruhlen, R., Marberry, K.
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Cilium assembly and disassembly [PDF]
Nature Cell Biology, 2016 The primary cilium is an antenna-like, immotile organelle present on most types of mammalian cells, which interprets extracellular signals that regulate growth and development. Although once considered a vestigial organelle, the primary cilium is now the focus of considerable interest.
Irma, Sánchez, Brian David, Dynlacht
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Primary cilium and glioblastoma [PDF]
Therapeutic Advances in Medical Oncology, 2018 Glioblastoma (GBM) represents the most common, malignant and lethal primary brain tumour in adults. The primary cilium is a highly conserved and dynamic organelle that protrudes from the apical surface of virtually every type of mammalian cell. There is increasing evidence that abnormal cilia are involved in cancer progression, since primary cilia ...
María Álvarez-Satta, Ander Matheu
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BMC Molecular and Cell Biology, 2020 Background Reversible cell cycle arrest (quiescence/G0) is characteristic of adult stem cells and is actively controlled at multiple levels. Quiescent cells also extend a primary cilium, which functions as a signaling hub.
Nisha Venugopal +5 more
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Cells, 2020 Cancer associated fibroblasts (CAFs) are central elements of the microenvironment that control tumor development. In breast cancer, CAFs can originate from adipose progenitors (APs).
Pascal Peraldi +3 more
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Frontiers in Genetics, 2022 Lung adenocarcinoma (LUAD) has become the most prevalent histologic subset of primary lung cancer, and effective innovative prognostic models are needed to enhance the feasibility of targeted therapies for the disease.
Huizhe Zhang +7 more
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Assembling a primary cilium [PDF]
Current Opinion in Cell Biology, 2013 Cilia are evolutionarily conserved, membrane-bound, microtubular projections emanating from the cell surface. They are assembled on virtually all cell types in the human body, with very few exceptions, and several recent reviews have covered the topic in great detail.
Sehyun, Kim, Brian David, Dynlacht
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Signaling through the Primary Cilium [PDF]
Frontiers in Cell and Developmental Biology, 2018 The presence of single, non-motile "primary" cilia on the surface of epithelial cells has been well described since the 1960s. However, for decades these organelles were believed to be vestigial, with no remaining function, having lost their motility.
Wheway, Gabrielle +2 more
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A recombinant BBSome core complex and how it interacts with ciliary cargo
eLife, 2017 Cilia are small, antenna-like structures on the surface of eukaryotic cells that harbor a unique set of sensory proteins, including GPCRs and other membrane proteins.
Björn Udo Klink +5 more
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