Results 11 to 20 of about 36,064 (332)
Evolution and persistence of the cilium [PDF]
Cell Motility, 2007 AbstractThe origin of cilia, a fundamental eukaryotic organelle, not present in prokaryotes, poses many problems, including the origins of motility and sensory function, the origins of nine‐fold symmetry, of basal bodies, and of transport and selective mechanisms involved in ciliogenesis. We propose the basis of ciliary origin to be a self‐assembly RNA
Peter Satir, Charles Guerra, Aaron Bell
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Seeing through the cilium [PDF]
The Journal of Cell Biology, 2002 ![Graphic][1] IFT88 (green) is found in mouse photoreceptor cilia (red).To understand vision in vertebrates, one might look to worms and algae, according to recent results. On [page 103][2], Pazour et al.
Nicole LeBrasseur
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The primary cilium at a glance [PDF]
Journal of Cell Science, 2010 The primary cilium, which was first so named by Sergei Sorokin ([Sorokin, 1968][1]), is a solitary organelle that emanates from the cell surface of most mammalian cell types during growth arrest.
Peter Satir +2 more
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Proteomic analysis of a eukaryotic cilium [PDF]
The Journal of Cell Biology, 2005 Cilia and flagella are widespread cell organelles that have been highly conserved throughout evolution and play important roles in motility, sensory perception, and the life cycles of eukaryotes ranging from protists to humans. Despite the ubiquity and importance of these organelles, their composition is not well known. Here we use mass spectrometry to
Gregory J. Pazour +3 more
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Primary cilium and glioblastoma [PDF]
Therapeutic Advances in Medical Oncology, 2018 Glioblastoma (GBM) represents the most common, malignant and lethal primary brain tumour in adults. The primary cilium is a highly conserved and dynamic organelle that protrudes from the apical surface of virtually every type of mammalian cell. There is increasing evidence that abnormal cilia are involved in cancer progression, since primary cilia ...
María Álvarez-Satta, Ander Matheu
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Trafficking in and to the primary cilium [PDF]
Cilia, 2012 Abstract Polarized vesicle trafficking is mediated by small GTPase proteins, such as Rabs and Arls/Arfs. These proteins have essential roles in maintaining normal cellular function, in part, through regulating intracellular trafficking. Moreover, these families of proteins have recently been implicated in the formation and function of the ...
Yi-Chun Hsiao +3 more
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The chondrocyte primary cilium [PDF]
Osteoarthritis and Cartilage, 2014 The presence and role of primary, or non-motile, cilia on chondrocytes has confused cartilage researchers for decades. Initial explanations attributed a vestigial nature to chondrocyte cilia. Evidence is now emerging that supports the role of the chondrocyte primary cilium as a sensory organelle, in particular, in mechanotransduction and as a ...
K. Marberry, R. Ruhlen
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Cilium assembly and disassembly [PDF]
Nature Cell Biology, 2016 The primary cilium is an antenna-like, immotile organelle present on most types of mammalian cells, which interprets extracellular signals that regulate growth and development. Although once considered a vestigial organelle, the primary cilium is now the focus of considerable interest.
Brian David Dynlacht, Irma Sánchez
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Cilium incarnatum externum [PDF]
Digital Journal of Ophthalmology, 2017 A 25-year-old woman presented with a history of a cosmetically bothersome bulge over her left eyelid. She was diagnosed with cilium incarnatum externum. The subcutaneous cilium was surgically removed and examined.
Ananya Chatterjee +4 more
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BMC Molecular and Cell Biology, 2020 Background Reversible cell cycle arrest (quiescence/G0) is characteristic of adult stem cells and is actively controlled at multiple levels. Quiescent cells also extend a primary cilium, which functions as a signaling hub.
Nisha Venugopal +5 more
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