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Kinase activity of DYRK family members is required for regulating primary cilium length, stability and morphology [PDF]
Communications BiologyThe dual-specificity tyrosine-phoshorylation-regulated kinase (DYRK) family are multifunctional enzymes crucial for diverse cellular processes, including signaling through the primary cilium. Their dysregulation has been implicated in various cancers and
Melis D. Arslanhan +2 more
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Post‐Translational Modifications in Cilia and Ciliopathies [PDF]
Advanced ScienceCilia are microtubule‐based organelles that extend from the surface of most vertebrate cells, and they play important roles in diverse cellular processes during embryonic development and tissue homeostasis.
Jie Ran, Jun Zhou
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Seeing through the cilium [PDF]
The Journal of Cell Biology, 2002 ![Graphic][1] IFT88 (green) is found in mouse photoreceptor cilia (red).To understand vision in vertebrates, one might look to worms and algae, according to recent results. On [page 103][2], Pazour et al.
Nicole LeBrasseur
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Evolution and persistence of the cilium [PDF]
Cell Motility, 2007 AbstractThe origin of cilia, a fundamental eukaryotic organelle, not present in prokaryotes, poses many problems, including the origins of motility and sensory function, the origins of nine‐fold symmetry, of basal bodies, and of transport and selective mechanisms involved in ciliogenesis. We propose the basis of ciliary origin to be a self‐assembly RNA
Peter Satir, Charles Guerra, Aaron Bell
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The primary cilium at a glance [PDF]
Journal of Cell Science, 2010 The primary cilium, which was first so named by Sergei Sorokin ([Sorokin, 1968][1]), is a solitary organelle that emanates from the cell surface of most mammalian cell types during growth arrest.
Peter Satir +2 more
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Proteomic analysis of a eukaryotic cilium [PDF]
The Journal of Cell Biology, 2005 Cilia and flagella are widespread cell organelles that have been highly conserved throughout evolution and play important roles in motility, sensory perception, and the life cycles of eukaryotes ranging from protists to humans. Despite the ubiquity and importance of these organelles, their composition is not well known. Here we use mass spectrometry to
Gregory J. Pazour +3 more
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Primary cilium and glioblastoma [PDF]
Therapeutic Advances in Medical Oncology, 2018 Glioblastoma (GBM) represents the most common, malignant and lethal primary brain tumour in adults. The primary cilium is a highly conserved and dynamic organelle that protrudes from the apical surface of virtually every type of mammalian cell. There is increasing evidence that abnormal cilia are involved in cancer progression, since primary cilia ...
María Álvarez-Satta, Ander Matheu
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Trafficking in and to the primary cilium [PDF]
Cilia, 2012 Abstract Polarized vesicle trafficking is mediated by small GTPase proteins, such as Rabs and Arls/Arfs. These proteins have essential roles in maintaining normal cellular function, in part, through regulating intracellular trafficking. Moreover, these families of proteins have recently been implicated in the formation and function of the ...
Yi-Chun Hsiao +3 more
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The chondrocyte primary cilium [PDF]
Osteoarthritis and Cartilage, 2014 The presence and role of primary, or non-motile, cilia on chondrocytes has confused cartilage researchers for decades. Initial explanations attributed a vestigial nature to chondrocyte cilia. Evidence is now emerging that supports the role of the chondrocyte primary cilium as a sensory organelle, in particular, in mechanotransduction and as a ...
K. Marberry, R. Ruhlen
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Cilium assembly and disassembly [PDF]
Nature Cell Biology, 2016 The primary cilium is an antenna-like, immotile organelle present on most types of mammalian cells, which interprets extracellular signals that regulate growth and development. Although once considered a vestigial organelle, the primary cilium is now the focus of considerable interest.
Brian David Dynlacht, Irma Sánchez
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