Results 31 to 40 of about 39,977 (306)
Cells, 2020 Cancer associated fibroblasts (CAFs) are central elements of the microenvironment that control tumor development. In breast cancer, CAFs can originate from adipose progenitors (APs).
Pascal Peraldi +3 more
doaj +1 more source
The IDA3 adapter, required for intraflagellar transport of I1 dynein, is regulated by ciliary length [PDF]
, 2018 Axonemal dyneins, including inner dynein arm I1, assemble in the cytoplasm prior to transport into cilia by intraflagellar transport (IFT). How I1 dynein interacts with IFT is not understood.
Alford, Lea M +14 more
core +2 more sources
Assembling a primary cilium [PDF]
Current Opinion in Cell Biology, 2013 Cilia are evolutionarily conserved, membrane-bound, microtubular projections emanating from the cell surface. They are assembled on virtually all cell types in the human body, with very few exceptions, and several recent reviews have covered the topic in great detail.
Sehyun, Kim, Brian David, Dynlacht
openaire +2 more sources
Mixing and transport by ciliary carpets: a numerical study [PDF]
, 2013 We use a 3D computational model to study the fluid transport and mixing due to the beating of an infinite array of cilia. In accord with recent experiments, we observe two distinct regions: a fluid transport region above the cilia and a fluid mixing ...
Ding, Yang +3 more
core +3 more sources
Signaling through the Primary Cilium [PDF]
Frontiers in Cell and Developmental Biology, 2018 The presence of single, non-motile "primary" cilia on the surface of epithelial cells has been well described since the 1960s. However, for decades these organelles were believed to be vestigial, with no remaining function, having lost their motility.
Wheway, Gabrielle +2 more
openaire +5 more sources
Frontiers in Genetics, 2022 Lung adenocarcinoma (LUAD) has become the most prevalent histologic subset of primary lung cancer, and effective innovative prognostic models are needed to enhance the feasibility of targeted therapies for the disease.
Huizhe Zhang +7 more
doaj +1 more source
A recombinant BBSome core complex and how it interacts with ciliary cargo
eLife, 2017 Cilia are small, antenna-like structures on the surface of eukaryotic cells that harbor a unique set of sensory proteins, including GPCRs and other membrane proteins.
Björn Udo Klink +5 more
doaj +1 more source
Heat shock induces rapid resorption of primary cilia [PDF]
, 2012 Primary cilia are involved in important developmental and disease pathways, such as the regulation of neurogenesis and tumorigenesis. They function as sensory antennae and are essential in the regulation of key extracellular signalling systems.
Anckar +32 more
core +1 more source
eLife, 2015 Small G-proteins of the ADP-ribosylation-factor-like (Arl) subfamily have been shown to be crucial to ciliogenesis and cilia maintenance. Active Arl3 is involved in targeting and releasing lipidated cargo proteins from their carriers PDE6δ and UNC119a/b ...
Katja Gotthardt +5 more
doaj +1 more source
Shortened primary cilium length and dysregulated Sonic hedgehog signaling in Niemann-Pick C1 disease [PDF]
, 2017 The Niemann-Pick type C1 (NPC1) disease is a neurodegenerative lysosomal storage disorder due to mutations in the NPC1 gene, encoding a transmembrane protein related to the Sonic hedgehog receptor, Patched, and involved in intracellular trafficking of ...
Canterini, Sonia +7 more
core +1 more source