Results 31 to 40 of about 6,760 (249)

Targeting of CRMP-2 to the primary cilium is modulated by GSK-3β. [PDF]

PLoS ONE, 2012
CRMP-2 plays a pivotal role in promoting axon formation, neurite outgrowth and elongation in neuronal cells. CRMP-2's role in other cells is unknown. Our preliminary results showed CRMP-2 expression in cilia of fibroblasts. To localize CRMP-2, define its
Young Ou, Ying Zhang, Min Cheng, Jerome B Rattner, Ina Dobrinski, Frans A van der Hoorn   +5 more
doaj   +1 more source

The primary cilium dampens proliferative signaling and represses a G2/M transcriptional network in quiescent myoblasts

BMC Molecular and Cell Biology, 2020
Background Reversible cell cycle arrest (quiescence/G0) is characteristic of adult stem cells and is actively controlled at multiple levels. Quiescent cells also extend a primary cilium, which functions as a signaling hub.
Nisha Venugopal, Ananga Ghosh, Hardik Gala, Ajoy Aloysius, Neha Vyas, Jyotsna Dhawan   +5 more
doaj   +1 more source

Autophagy and the primary cilium in cell metabolism: What’s upstream?

Frontiers in Cell and Developmental Biology, 2022
The maintenance of cellular homeostasis in response to extracellular stimuli, i.e., nutrient and hormone signaling, hypoxia, or mechanical forces by autophagy, is vital for the health of various tissues.
Aurore Claude-Taupin, Nicolas Dupont, Patrice Codogno   +2 more
doaj   +1 more source

Interleukin-1β sequesters hypoxia inducible factor 2α to the primary cilium. [PDF]

, 2013
BACKGROUND: The primary cilium coordinates signalling in development, health and disease. Previously we have shown that the cilium is essential for the anabolic response to loading and the inflammatory response to interleukin-1β (IL-1β).
Wann, AK, Wann, Angus K.T., Chapple, JP, Knight, MM, Knight, Martin M., Thompson, CL, Thompson, Clare L., Chapple, J. Paul   +7 more
core   +1 more source

The chondrocyte primary cilium [PDF]

Osteoarthritis and Cartilage, 2014
The presence and role of primary, or non-motile, cilia on chondrocytes has confused cartilage researchers for decades. Initial explanations attributed a vestigial nature to chondrocyte cilia. Evidence is now emerging that supports the role of the chondrocyte primary cilium as a sensory organelle, in particular, in mechanotransduction and as a ...
Ruhlen, R., Marberry, K.
openaire   +2 more sources

The Primary Cilium of Adipose Progenitors Is Necessary for Their Differentiation into Cancer-Associated Fibroblasts that Promote Migration of Breast Cancer Cells In Vitro

Cells, 2020
Cancer associated fibroblasts (CAFs) are central elements of the microenvironment that control tumor development. In breast cancer, CAFs can originate from adipose progenitors (APs).
Pascal Peraldi, Annie Ladoux, Sophie Giorgetti-Peraldi, Christian Dani   +3 more
doaj   +1 more source

The Drosophila orthologue of the primary ciliary dyskinesia-associated gene, DNAAF3, is required for axonemal dynein assembly

Biology Open, 2021
Ciliary motility is powered by a suite of highly conserved axoneme-specific dynein motor complexes. In humans, the impairment of these motors through mutation results in the disease primary ciliary dyskinesia (PCD).
Petra zur Lage, Zhiyan Xi, Jennifer Lennon, Iain Hunter, Wai Kit Chan, Alfonso Bolado Carrancio, Alex von Kriegsheim, Andrew P. Jarman   +7 more
doaj   +1 more source

Trainspotting in a cilium

eLife, 2017
A new imaging technique sheds light on how cilia regulate their length and growth.
Dhivya Kumar, Stephen M King
openaire   +3 more sources

Primary cilia elongation in response to interleukin-1 mediates the inflammatory response [PDF]

, 2012
Primary cilia are singular, cytoskeletal organelles present in the majority of mammalian cell types where they function as coordinating centres for mechanotransduction, Wnt and hedgehog signalling. The length of the primary cilium is proposed to modulate
Knight, M.M., A. K. T. Wann, Wann, A.K.T., Knight, MM, Wann, AKT, M. M. Knight   +5 more
core   +1 more source

Ciliated, Mitochondria-Rich Postmitotic Cells are Immune-privileged, and Mimic Immunosuppressive Microenvironment of Tumor-Initiating Stem Cells: From Molecular Anatomy to Molecular Pathway

Frontiers in Bioscience-Landmark, 2023
Cancer whose major problems are metastasis, treatment resistance, and recurrence is the leading cause of death worldwide. Tumor-initiating stem cells (TiSCs) are a subset of the tumor population responsible for tumor resistance and relapse. Understanding
Babak Behnam, Hassan Fazilaty, Mobina Ghadyani, Pedram Fadavi, Farzad Taghizadeh-Hesary   +4 more
doaj   +1 more source