Results 11 to 20 of about 22,757 (263)
The nociceptor primary cilium. [PDF]
BrainAbstract The primary cilium, a single microtubule-based organelle protruding from the surface of cells, uses intraflagellar transport to establish and maintain its structure and function. It is well-established to guide development and function of the nervous system through signalling pathways identified by expression of molecular ...
Ganter GK +5 more
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Cilium incarnatum externum [PDF]
Digital Journal of Ophthalmology, 2017 A 25-year-old woman presented with a history of a cosmetically bothersome bulge over her left eyelid. She was diagnosed with cilium incarnatum externum. The subcutaneous cilium was surgically removed and examined.
Taru, Dewan +4 more
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Evolution and persistence of the cilium [PDF]
Cell Motility, 2007 AbstractThe origin of cilia, a fundamental eukaryotic organelle, not present in prokaryotes, poses many problems, including the origins of motility and sensory function, the origins of nine‐fold symmetry, of basal bodies, and of transport and selective mechanisms involved in ciliogenesis. We propose the basis of ciliary origin to be a self‐assembly RNA
Peter, Satir +2 more
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The chondrocyte primary cilium [PDF]
Osteoarthritis and Cartilage, 2014 The presence and role of primary, or non-motile, cilia on chondrocytes has confused cartilage researchers for decades. Initial explanations attributed a vestigial nature to chondrocyte cilia. Evidence is now emerging that supports the role of the chondrocyte primary cilium as a sensory organelle, in particular, in mechanotransduction and as a ...
Ruhlen, R., Marberry, K.
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Trafficking in and to the primary cilium [PDF]
Cilia, 2012 Abstract Polarized vesicle trafficking is mediated by small GTPase proteins, such as Rabs and Arls/Arfs. These proteins have essential roles in maintaining normal cellular function, in part, through regulating intracellular trafficking. Moreover, these families of proteins have recently been implicated in the formation and function of the ...
Hsiao, Yi-Chun +2 more
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Ciliary Dyneins and Dynein Related Ciliopathies
Cells, 2021 Although ubiquitously present, the relevance of cilia for vertebrate development and health has long been underrated. However, the aberration or dysfunction of ciliary structures or components results in a large heterogeneous group of disorders in ...
Dinu Antony +2 more
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BMC Molecular and Cell Biology, 2020 Background Reversible cell cycle arrest (quiescence/G0) is characteristic of adult stem cells and is actively controlled at multiple levels. Quiescent cells also extend a primary cilium, which functions as a signaling hub.
Nisha Venugopal +5 more
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Targeting of CRMP-2 to the primary cilium is modulated by GSK-3β. [PDF]
PLoS ONE, 2012 CRMP-2 plays a pivotal role in promoting axon formation, neurite outgrowth and elongation in neuronal cells. CRMP-2's role in other cells is unknown. Our preliminary results showed CRMP-2 expression in cilia of fibroblasts. To localize CRMP-2, define its
Young Ou +5 more
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A Cilium Is Not a Cilium Is Not a Cilium: Signaling Contributes to Ciliary Morphological Diversity [PDF]
Developmental Cell, 2008 Mukhopadhyay and colleagues reveal in this issue of Developmental Cell that signaling mediated by a specialized neuronal cilium in C. elegans affects its structure. The finding that this cilium is modified in response to the cues it transduces suggests that cilia may not be static antennae, but organelles whose functions are shaped by their signaling ...
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The primary cilium at a glance [PDF]
Journal of Cell Science, 2010 The primary cilium, which was first so named by Sergei Sorokin ([Sorokin, 1968][1]), is a solitary organelle that emanates from the cell surface of most mammalian cell types during growth arrest.
Satir, Peter +2 more
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