Results 191 to 200 of about 36,064 (332)
LZTS2 Negatively Regulates Centrosomal CEP135 Levels and Microtubule Nucleation
Cytoskeleton, EarlyView.ABSTRACT The microtubule cytoskeleton is a fundamental functional component of the cell. In vertebrate proliferating cells, centrosomes are the primary microtubule organizing center (MTOC), and their dysregulation has been linked to genomic instability and cancer.
Catarina Peneda +4 more
wiley +1 more source
Endophthalmitis Caused by an Intraocular Cilium [PDF]
, 2010 Mijin Kim, Jang Won Heo, Hum Chung
openalex +1 more source
Dynamics of primary cilia in endothelial and mesenchymal cells throughout mouse lung development
Developmental Dynamics, EarlyView.Abstract Cilia are specialized structures found on a variety of mammalian cells, with variable roles in the transduction of mechanical and biological signals (by primary cilia, PC), as well as in the generation of fluid flow (by motile cilia). Their critical role in the establishment of a left–right axis in early development is well described, as well ...
Stephen Spurgin +8 more
wiley +1 more source
It’s not all in the cilium, but on the road to it: Genetic interaction network in polycystic kidney and liver diseases and how trafficking and quality control matter [PDF]
, 2011 Carsten Bergmann, Ralf Weiskirchen
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Developmental Dynamics, EarlyView.Abstract Background Freshwater salinization is an emerging stressor in amphibian populations, and embryonic stages are most vulnerable. To better understand the variation in embryonic osmoregulation, we challenged embryos of two phylogenetically diverse anuran species, Xenopus laevis and Lithobates (Rana) sylvaticus, along a gradient of non‐lethal ...
Kourtnie Whitfield, Erica J. Crespi
wiley +1 more source
An ARL3–UNC119–RP2 GTPase cycle targets myristoylated NPHP3 to the primary cilium [PDF]
, 2011 Kevin J. Wright +11 more
openalex +1 more source
Developmental Dynamics, EarlyView.Abstract Homology in vertebrate body plans is traditionally ascribed to the high‐level conservation of regulatory components within the genetic programs governing them, particularly during the “phylotypic stage.” However, advancements in embryology and molecular phylogeny have unveiled the dynamic nature of gene repertoires responsible for early ...
Shigehiro Kuraku
wiley +1 more source
Loss of a primary cilium in PDAC [PDF]
Cell Cycle, 2017 Hiroshi Itoh, Tetsuo Kobayashi
openaire +3 more sources
Molecular anatomy of emerging Xenopus left–right organizer at successive developmental stages
Developmental Dynamics, EarlyView.Abstract Background Vertebrate left–right symmetry breaking is preceded by formation of left–right organizer. In Amphibian, this structure is formed by gastrocoel roof plate, which emerges from superficial suprablastoporal cells. GRP is subdivided into medial area, which generates leftward flow by rotating monocilia and lateral Nodal1 expressing areas,
Natalia Petri +3 more
wiley +1 more source