Results 181 to 190 of about 40,089 (306)

Primary cilia regulate GLP-1 signaling in pancreatic β cells. [PDF]

Mol Metab
Melena I, Jo JH, Townsend SE, DiGruccio SA, Dong X, Zhu L, Campbell J, Hughes JW.   +7 more
europepmc   +1 more source

Immunotherapy‐Related Cutaneous Toxicities in Melanoma: A Dermoscopic Perspective

JEADV Clinical Practice, EarlyView.
Dermoscopy serves as a valuable tool in the everyday dermatological and oncological practice for melanoma patients, allowing for the prompt identification of immune‐related cutaneous toxicities and guiding clinicians toward appropriate therapeutic decisions.
Grażyna Kamińska‐Winciorek, Iris Zalaudek, Karolina Zarańska, Bożena Cybulska‐Stopa   +3 more
wiley   +1 more source

Recalcitrant Eyelid Lupus Treated With Topical Ruxolitinib

JEADV Clinical Practice, EarlyView.
ABSTRACT Lupus of the eyelids, or lupus blepharitis, is a rare and localized form of chronic cutaneous lupus. The use of topical corticosteroids is limited in this sensitive area due to the risk of adverse events. We present a case of eyelid lupus, with histological confirmation, resistant to multiple lines of treatment, successfully treated with ...
Clémence Bertold, Feriel Boukari, Valérie Elmaleh, Julia Bonnelye, Ulysse Jacquier, Nathalie Cardot‐Leccia, Thierry Passeron   +6 more
wiley   +1 more source

Commentary: Could We Address the Interplay Between CD133, Wnt/β-Catenin, and TERT Signaling Pathways as a Potential Target for Glioblastoma Therapy?

Frontiers in Oncology, 2021
Christine A. Fargeas, Aurelio Lorico, Denis Corbeil   +2 more
doaj   +1 more source

Altered ciliary morphology reduces mechanosensation in a cystic kidney model as indicated by a mathematical model. [PDF]

Sci Rep
Kumamoto K, Kagami H, Saitoh S, Yamada S, Matsumoto M, Ohno N.   +5 more
europepmc   +1 more source

Radiotherapy‐Induced Otitis Media With Effusion in Nasopharyngeal Carcinoma: A Meta‐Analysis

The Laryngoscope, EarlyView.
This meta‐analysis of eight studies comprising 582 NPC patients provides the first quantitative synthesis of radiotherapy‐induced otitis media with effusion (OME), demonstrating a significant overall risk difference of 0.18 (95% CI: −0.06 to 0.42, p < 0.0001) in OME naive ears.
Nevin Yi Meng Chua, Yong Hoe Chan, Woei Shyang Loh, De Yun Wang   +3 more
wiley   +1 more source

Advances in GPCRs Associated With Wnt Signaling Within the Auditory System

Medicine Bulletin, EarlyView.
ABSTRACT G protein‐coupled receptors (GPCRs) that interact with the Wnt signaling pathway are pivotal for auditory system homeostasis, as they orchestrate inner ear development, hair cell (HC) regeneration, and hearing preservation. Frizzled (FZD) receptors, the core Wnt‐related GPCRs, bind Wnt ligands and co‐receptors (e.g., LRP5/6) to activate both ...
Liang Wang, Changling Xu, Jiangang Fan, Renjie Chai   +3 more
wiley   +1 more source

Glucagon secretion by pancreatic alpha-cells requires an intact tubulin-cytoskeleton-primary cilium axis. [PDF]

Mol Med
Casanueva-Álvarez E, Sanz-González A, Vilas A, Cámara-Torres P, Ravier MA, Eslava-Alcon S, Duran-Ruiz MC, Ramírez CM, Petropoulou PI, Rodriguez-Calvo T, Merino B, Perdomo G, Cozar-Castellano I.   +12 more
europepmc   +1 more source

Ex Vivo LRRK2 Activation in Asian G2385R and R1628P Variant Carriers and Idiopathic Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Leucine‐rich repeat kinase 2 (LRRK2) kinase inhibition is a promising therapeutic strategy for Parkinson's disease (PD), but the functional impact of Asian‐prevalent LRRK2 p.G2385R and p.R1628P variants remains unclear. Robust patient stratification and target engagement markers are needed for global LRRK2‐targeted trials ...
Tzi Shin Toh, Lei Cheng Lit, Shen‐Yang Lim, Jia Wei Hor, Choey Yee Lew, Anis Nadhirah Khairul Anuar, Yi Wen Tay, Kirsten Black, Jia Lun Lim, Jannah Zulkefli, Kai Shi Lim, Hans Xing Ding, Shalini Padmanabhan, Azlina Ahmad‐Annuar, Eng King Tan, Dario R. Alessi, Esther Sammler, Ai Huey Tan   +17 more
wiley   +1 more source

<i>Astragalus</i> small molecules protect BMSCs from radiation-induced bystander effect and enhance lung cancer radiosensitivity via the primary cilium/TGF-βR1/Smad3 pathway. [PDF]

Front Oncol
Miao Z, Wu M, Dai S, Wang X, Li YY, Liu F, Liu Z, Zhang L, Liu Y.   +8 more
europepmc   +1 more source