Results 21 to 30 of about 41,549 (330)

Targeting of CRMP-2 to the primary cilium is modulated by GSK-3β. [PDF]

PLoS ONE, 2012
CRMP-2 plays a pivotal role in promoting axon formation, neurite outgrowth and elongation in neuronal cells. CRMP-2's role in other cells is unknown. Our preliminary results showed CRMP-2 expression in cilia of fibroblasts. To localize CRMP-2, define its
Young Ou, Ying Zhang, Min Cheng, Jerome B Rattner, Ina Dobrinski, Frans A van der Hoorn   +5 more
doaj   +1 more source

Interleukin-1β sequesters hypoxia inducible factor 2α to the primary cilium. [PDF]

, 2013
BACKGROUND: The primary cilium coordinates signalling in development, health and disease. Previously we have shown that the cilium is essential for the anabolic response to loading and the inflammatory response to interleukin-1β (IL-1β).
AC Lin, AK Wann, AK Wann, AM Malone, AR Sartori-Cintra, BL Thoms, BL Thoms, CA Clement, CA Clement, CF Chang, CJ Haycraft, CJ Haycraft, CR Thoma, D Kong, D Zhu, DA Hoey, DM Katschinski, E Verghese, EN Pugacheva, F Oeffner, GJ Pazour, HA Praetorius, J Kim, JB Catterall, JC Kim, JE Bohonowych, JE Lafont, JF Reiter, JH Moyer, JH Ryu, JM Gerdes, JR Marszalek, JT Eggenschwiler, KC Corbit, KC Corbit, L Schneider, M Windheim, MA Lancaster, MF Bijlsma, NV Prodromou, P Jaakkola, PD Taulman, PV Tran, R Rohatgi, RD Thornton, S Abdul-Majeed, S Kim, S Massinen, S Murakami, S Proulx-Bonneau, S Yang, SH Low, SM Nauli, SN Greer, SR McGlashan, SR McGlashan, T Caspary, TY Besschetnova, X Xue, Y Li, YJ Jung   +60 more
core   +1 more source

Design and Fabrication of an Integrated Hollow Concave Cilium MEMS Cardiac Sound Sensor

Micromachines, 2022
In light of a need for low-frequency, high sensitivity and broadband cardiac murmur signal detection, the present work puts forward an integrated MEMS-based heart sound sensor with a hollow concave ciliary micro-structure. The advantages of a hollow MEMS
Bo Wang, Pengcheng Shi, Yuhua Yang, Jiangong Cui, Guojun Zhang, Renxin Wang, Wendong Zhang, Changde He, Yirui Li, Shuotong Wang   +9 more
doaj   +1 more source

Assembling a primary cilium [PDF]

Current Opinion in Cell Biology, 2013
Cilia are evolutionarily conserved, membrane-bound, microtubular projections emanating from the cell surface. They are assembled on virtually all cell types in the human body, with very few exceptions, and several recent reviews have covered the topic in great detail.
Sehyun, Kim, Brian David, Dynlacht
openaire   +2 more sources

The Primary Cilium of Adipose Progenitors Is Necessary for Their Differentiation into Cancer-Associated Fibroblasts that Promote Migration of Breast Cancer Cells In Vitro

Cells, 2020
Cancer associated fibroblasts (CAFs) are central elements of the microenvironment that control tumor development. In breast cancer, CAFs can originate from adipose progenitors (APs).
Pascal Peraldi, Annie Ladoux, Sophie Giorgetti-Peraldi, Christian Dani   +3 more
doaj   +1 more source

Signaling through the Primary Cilium [PDF]

Frontiers in Cell and Developmental Biology, 2018
The presence of single, non-motile "primary" cilia on the surface of epithelial cells has been well described since the 1960s. However, for decades these organelles were believed to be vestigial, with no remaining function, having lost their motility.
Wheway, Gabrielle, Nazlamova, Liliya, Hancock, John T.   +2 more
openaire   +5 more sources

A novel defined cuproptosis-related gene signature for predicting the prognosis of lung adenocarcinoma

Frontiers in Genetics, 2022
Lung adenocarcinoma (LUAD) has become the most prevalent histologic subset of primary lung cancer, and effective innovative prognostic models are needed to enhance the feasibility of targeted therapies for the disease.
Huizhe Zhang, Yanchen Shi, Qing Yi, Cong Wang, Qingqing Xia, Yufeng Zhang, Weilong Jiang, Jia Qi   +7 more
doaj   +1 more source

Mixing and transport by ciliary carpets: a numerical study [PDF]

, 2013
We use a 3D computational model to study the fluid transport and mixing due to the beating of an infinite array of cilia. In accord with recent experiments, we observe two distinct regions: a fluid transport region above the cilia and a fluid mixing ...
Ding, Yang, Kanso, Eva, McFall-Ngai, Margaret, Nawroth, Janna   +3 more
core   +3 more sources

A recombinant BBSome core complex and how it interacts with ciliary cargo

eLife, 2017
Cilia are small, antenna-like structures on the surface of eukaryotic cells that harbor a unique set of sensory proteins, including GPCRs and other membrane proteins.
Björn Udo Klink, Eldar Zent, Puneet Juneja, Anne Kuhlee, Stefan Raunser, Alfred Wittinghofer   +5 more
doaj   +1 more source

Smoothened adopts multiple active and inactive conformations capable of trafficking to the primary cilium. [PDF]

, 2009
Activation of Hedgehog (Hh) signaling requires the transmembrane protein Smoothened (Smo), a member of the G-protein coupled receptor superfamily. In mammals, Smo translocates to the primary cilium upon binding of Hh ligands to their receptor, Patched ...
Chen, Miao-Hsueh, Chuang, Pao-Tien, Wilson, Christopher W   +2 more
core   +3 more sources