Results 21 to 30 of about 22,114 (247)
eLife, 2015 Small G-proteins of the ADP-ribosylation-factor-like (Arl) subfamily have been shown to be crucial to ciliogenesis and cilia maintenance. Active Arl3 is involved in targeting and releasing lipidated cargo proteins from their carriers PDE6δ and UNC119a/b ...
Katja Gotthardt +5 more
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Dissecting the Vesicular Trafficking Function of IFT Subunits
Frontiers in Cell and Developmental Biology, 2020 Intraflagellar transport (IFT) was initially identified as a transport machine with multiple protein subunits, and it is essential for the assembly, disassembly, and maintenance of cilium/flagellum, which serves as the nexus of extracellular-to ...
Huihui Yang, Huihui Yang, Kaiyao Huang
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Dendritic cell proliferation by primary cilium in atopic dermatitis
Frontiers in Molecular Biosciences, 2023 Introduction: Atopic dermatitis (AD) is a common allergic eczema that affects up to 10% of adults in developed countries. Immune cells in the epidermis, namely, Langerhans cells (LCs), contribute to the pathogenesis of AD, although their exact role(s) in
Manami Toriyama +19 more
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In-phase and anti-phase flagellar synchronization by waveform compliance and basal coupling
New Journal of Physics, 2017 We present a theory of flagellar synchronization in the green alga Chlamydomonas , using full treatment of flagellar hydrodynamics and measured beat patterns.
Gary S Klindt +3 more
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Targeting of CRMP-2 to the primary cilium is modulated by GSK-3β. [PDF]
PLoS ONE, 2012 CRMP-2 plays a pivotal role in promoting axon formation, neurite outgrowth and elongation in neuronal cells. CRMP-2's role in other cells is unknown. Our preliminary results showed CRMP-2 expression in cilia of fibroblasts. To localize CRMP-2, define its
Young Ou +5 more
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Predicting the locations of force-generating dyneins in beating cilia and flagella
Frontiers in Cell and Developmental Biology, 2022 Cilia and flagella are slender cylindrical organelles whose bending waves propel cells through fluids and drive fluids across epithelia. The bending waves are generated by dynein motor proteins, ATPases whose force-generating activity changes over time ...
Jonathon Howard +7 more
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Autophagy and the primary cilium in cell metabolism: What’s upstream?
Frontiers in Cell and Developmental Biology, 2022 The maintenance of cellular homeostasis in response to extracellular stimuli, i.e., nutrient and hormone signaling, hypoxia, or mechanical forces by autophagy, is vital for the health of various tissues.
Aurore Claude-Taupin +2 more
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The Cilium Secretes Bioactive Ectosomes [PDF]
Current Biology, 2013 The release of membrane vesicles from the surface of cells into their surrounding environment is now recognized as an important pathway for the delivery of proteins to extracellular sites of biological function. Membrane vesicles of this kind, termed exosomes and ectosomes, are the result of active processes and have been shown to carry a wide array of
Wood, Christopher R. +3 more
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eLife, 2017 A new imaging technique sheds light on how cilia regulate their length and growth.
Dhivya Kumar, Stephen M King
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Primary Cilium-Dependent Signaling Mechanisms [PDF]
International Journal of Molecular Sciences, 2017 Primary cilia are hair-like organelles and play crucial roles in vertebrate development, organogenesis, health, and many genetic disorders. A primary cilium is a mechano-sensory organelle that responds to mechanical stimuli in the micro-environment. A cilium is also a chemosensor that senses chemical signals surrounding a cell.
Pala, Rajasekharreddy +2 more
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