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Circadian clocks: It's time for chronobiology. [PDF]
PLoS Biology, 2023 Circadian clocks are everywhere, yet we still have not translated the vast knowledge gained in the past 20 years on the properties of circadian clocks into practical applications.
Martha Merrow
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Reciprocal Interactions between Circadian Clocks, Food Intake, and Energy Metabolism [PDF]
Biology, 2023 Like other biological functions, food intake and energy metabolism display daily rhythms controlled by the circadian timing system that comprises a main circadian clock and numerous secondary clocks in the brain and peripheral tissues.
Emma Grosjean +2 more
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Cellular mechano-environment regulates the mammary circadian clock [PDF]
Nature Communications, 2017 Circadian clocks regulate physiological and behavioural rhythms. Here, the authors show that the stiffness of the extracellular environment regulates circadian clocks in murine breast epithelium via Rho signalling, and explain how extracellular matrix ...
Nan Yang +10 more
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Time to Eat Your Vegetables: The Role of Circadian Clocks in Insect Herbivory [PDF]
InsectsInsects exhibit a range of ecological relationships with plants, including pollination, seed dispersal, parasitism, predation, and herbivory. Interactions between insects and plants are shaped by internal daily timekeeping systems in both sets of ...
Lena Smith +4 more
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Hundreds of LncRNAs Display Circadian Rhythmicity in Zebrafish Larvae
Cells, 2021 Long noncoding RNAs (lncRNAs) have been shown to play crucial roles in various life processes, including circadian rhythms. Although next generation sequencing technologies have facilitated faster profiling of lncRNAs, the resulting datasets require ...
Shital Kumar Mishra +2 more
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Computational Analysis Predicts Hundreds of Coding lncRNAs in Zebrafish
Biology, 2021 Recent studies have demonstrated that numerous long noncoding RNAs (ncRNAs having more than 200 nucleotide base pairs (lncRNAs)) actually encode functional micropeptides, which likely represents the next regulatory biology frontier.
Shital Kumar Mishra, Han Wang
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Real time, in vivo measurement of neuronal and peripheral clocks in Drosophila melanogaster
eLife, 2022 Circadian clocks are highly conserved transcriptional regulators that control ~24 hr oscillations in gene expression, physiological function, and behavior.
Peter S Johnstone +6 more
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Circadian Biology: Clocks within Clocks [PDF]
Current Biology, 2005 A small cluster of approximately 20,000 neurons in the ventral hypothalamus provide the body with key time-keeping signals and drive circadian rhythms. This circadian clock exhibits surprisingly complex substructures, with inputs from the retina, and outputs to other brain structures.
Piggins, Hugh D., Loudon, Andrew
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Circadian Clocks: Translation Lost [PDF]
Current Biology, 2005 One of the big questions in biological rhythms research is how a stable and precise circa-24 hour oscillation is generated on the molecular level. While increasing complexity seemed to be the key, a recent report suggests that circa-24 hour rhythms can be generated by just four molecules incubated in a test tube.
Roenneberg, T, Merrow, M
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A broken circadian clock: The emerging neuro-immune link connecting depression to cancer
Brain, Behavior, & Immunity - Health, 2022 Circadian clocks orchestrate daily rhythms in many organisms and are essential for optimal health. Circadian rhythm disrupting events, such as jet-lag, shift-work, night-light exposure and clock gene alterations, give rise to pathologic conditions that ...
Keyu Su +11 more
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