Results 91 to 100 of about 143,667 (304)

Time‐course characterization of intraocular pressure in murine steroid‐induced ocular hypertension: Effects of route, schedule, and concentration

Animal Models and Experimental Medicine, EarlyView.
Steroid‐induced ocular hypertension is a useful mouse model for glaucoma, but published work rarely quantifies how route, dose, and schedule shape the intraocular pressure (IOP) time‐course—hindering reproducibility and forcing labs to pilot protocols.
Nicholas Y. Q. Tan, Sai Bo Bo Tun, Hla Myint Htoon, Veluchamy Amutha Barathi, Tina T. Wong   +4 more
wiley   +1 more source

Sleep and Circadian Rhythms in Survivors of Acute Respiratory Failure

Frontiers in Neurology, 2020
Background: Little is known about sleep and circadian rhythms in survivors of acute respiratory failure (ARF) after hospital discharge.Objectives: To examine sleep and rest-activity circadian rhythms in ARF survivors 3 months after hospital discharge ...
Pei-Lin Yang, Teresa M. Ward, Robert L. Burr, Vishesh K. Kapur, Susan M. McCurry, Michael V. Vitiello, Catherine L. Hough, Elizabeth C. Parsons, Elizabeth C. Parsons   +8 more
doaj   +1 more source

Sex as a biological variable in nonclinical studies: Bridging scientific rigor, animal welfare, and regulatory expectations

Animal Models and Experimental Medicine, EarlyView.
Sex as a biological variable (SABV) is a critical determinant of pharmacokinetics, pharmacodynamics, and toxicity in nonclinical studies. This review highlights how inappropriate neglect of sex differences compromises animal welfare, scientific reproducibility, and regulatory compliance.
Kenta Onuma, Masaki Watanabe, Nobuya Sasaki   +2 more
wiley   +1 more source

Understanding the role of chromatin remodeling in the regulation of circadian transcription in Drosophila. [PDF]

, 2015
Circadian clocks enable organisms to anticipate daily changes in the environment and coordinate temporal rhythms in physiology and behavior with the 24-h day-night cycle. The robust cycling of circadian gene expression is critical for proper timekeeping,
Chiu, Joanna C, Kwok, Rosanna S, Lam, Vu H   +2 more
core   +1 more source

Gut Health in Ostriches (Struthio camelus): Insights Into Intestinal Structure, Functions, Microbiome, and Improvement Strategies

Animal Research and One Health, EarlyView.
Our paper systematically reviews the intestinal structure, function, and microbiota of ostriches, along with strategies for improving their gut health. We analyze how these factors collectively influence intestinal homeostasis and ostrich welfare, emphasizing probiotics as a promising intervention to enhance gut health, boost population well‐being, and
Zi‐Qun Zhang, Fang‐Fang Guo, Wen‐Juan Du, Meng Li, Aftab Shaukat, Zhu‐Qing Jia, Shu‐Cheng Huang   +6 more
wiley   +1 more source

Chronotherapy and intervertebral disc degeneration: understanding the role of circadian rhythm in degenerative processes

Frontiers in Cell and Developmental Biology
Intervertebral disc degeneration (IDD) and low back pain are prevalent issues globally, affecting a significant portion of the adult population. Recent research has highlighted the crucial role of circadian rhythms in the degenerative processes of ...
Cong Zhang, Cong Zhang, Cong Zhang, Rende Zhang, Guanghai Zhao, Guanghai Zhao, Guanghai Zhao, Zuolong Wu, Zuolong Wu, Zuolong Wu, Wei Song, Wei Song, Wei Song, Rui Ran, Rui Ran, Rui Ran, Kaisheng Zhou, Kaisheng Zhou, Kaisheng Zhou, Haihong Zhang, Haihong Zhang, Haihong Zhang   +21 more
doaj   +1 more source

Circadian rhythms and post-transcriptional regulation in higher plants [PDF]

, 2015
The circadian clock of plants allows them to cope with daily changes in their environment. This is accomplished by the rhythmic regulation of gene expression, in a process that involves many regulatory steps.
Romanowski, Andrés, Yanovsky, Marcelo Javier   +1 more
core   +3 more sources

Clock genes regulate Ca2+ signaling and mitochondrial bioenergetics to inhibit Sjogren's disease

Arthritis &Rheumatology, Accepted Article.
Objective Although Ca2+ signaling and metabolism have been identified as key determinants for the development of Sjogren's disease (SjD), the intricate connection between them and salivary gland physiology remains poorly understood. Methods Fluorescence‐based Ca2+ imaging, RNA seq, and mitochondrial activity were used to investigate the effects of ...
Viktor R. Drel, Manigandan Venkatesan, Rahul S. Jasrotia, Yuyang Sun, Viviane Nascimento Da Conceicao, Neelanjan Vishnu, Shankara N Varadarajan, Venugopal R. Bovilla, Rajender K Motiani, Shobhan Gaddameedhi, Bibhuti B. Mishra, Muniswamy Madesh, Brij B. Singh   +12 more
wiley   +1 more source

Rhythmic potassium transport regulates the circadian clock in human red blood cells

Nature Communications, 2017
Circadian rhythms usually rely on cyclic variations in gene expression. Red blood cells, however, display circadian rhythms while being devoid of nuclear DNA.
Erin A. Henslee, Priya Crosby, Stephen J. Kitcatt, Jack S. W. Parry, Andrea Bernardini, Rula G. Abdallat, Gabriella Braun, Henry O. Fatoyinbo, Esther J. Harrison, Rachel S. Edgar, Kai F. Hoettges, Akhilesh B. Reddy, Rita I. Jabr, Malcolm von Schantz, John S. O’Neill, Fatima H. Labeed   +15 more
doaj   +1 more source

Circadian Regulation of Synaptic Plasticity

Biology, 2016
Circadian rhythms refer to oscillations in biological processes with a period of approximately 24 h. In addition to the sleep/wake cycle, there are circadian rhythms in metabolism, body temperature, hormone output, organ function and gene expression ...
Marcos G. Frank
doaj   +1 more source