Results 91 to 100 of about 206,395 (302)

Automating AI Discovery for Biomedicine Through Knowledge Graphs and Large Language Models Agents

Advanced Intelligent Discovery, EarlyView.
This work proposes a novel framework that automates biomedical discovery by integrating knowledge graphs with multiagent large language models. A biologically aligned graph exploration strategy identifies hidden pathways between biomedical entities, and specialized agents use this pathway to iteratively design AI predictors and wet‐lab validation ...
Naafey Aamer, Muhammad Nabeel Asim, Shan Munir, Andreas Dengel   +3 more
wiley   +1 more source

Higher central circadian temperature amplitude is associated with greater metabolite rhythmicity in humans

Scientific Reports
Robust circadian rhythms are essential for optimal health. The central circadian clock controls temperature rhythms, which are known to organize the timing of peripheral circadian rhythms in rodents.
Daniel P. Windred, Clare Anderson, Katherine J. Jeppe, Suzanne Ftouni, Leilah K. Grant, Brunda Nijagal, Shantha M. W. Rajaratnam, Malcolm McConville, Dedreia Tull, Steven W. Lockley, Sean W. Cain, Andrew J. K. Phillips   +11 more
doaj   +1 more source

The role of temperature on the development of circadian rhythms in honey bee workers [PDF]

PeerJ
Circadian rhythms in honey bees are involved in various processes that impact colony survival. For example, young nurses take care of the brood constantly throughout the day and lack circadian rhythms.
Manuel A. Giannoni-Guzmán, Eddie Perez Claudio, Janpierre Aleman-Rios, Gabriel Diaz Hernandez, Melina Perez Torres, Alexander Melendez Moreno, Darimar Loubriel, Darrell Moore, Tugrul Giray, Jose L. Agosto-Rivera   +9 more
doaj   +2 more sources

Metals and Circadian Rhythms [PDF]

, 2017
Circadian rhythms describe the behavioral and physiological changes that occur in living organisms in order to attune to a 24 hour cycle of day and night. The most striking aspect of circadian function is the sleep-wake cycle, however many other physiological processes are regulated in 24 hour oscillations, including blood pressure, body temperature ...
Nancy L, Parmalee, Michael, Aschner
openaire   +2 more sources

Initial Stay Time and Work‐Rest Scheduling During Consecutive Heavy‐Intensity Workdays in Hot Environments in Young and Older Males

American Journal of Industrial Medicine, EarlyView.
ABSTRACT Introduction This study examined initial stay times (IST), defined as the duration of uninterrupted work before core temperature approaches recommended safety limits (38.0°C, ~1.0°C above baseline), and the efficacy of work‐rest cycles during repeated heavy work across consecutive workdays in young and older males.
Glen P. Kenny, Gil Bourgois, Sarah M. Taggart, Kelli E. McCormick, James J. McCormick, Leonidas G. Ioannou, Fergus K. O'Connor   +6 more
wiley   +1 more source

Understanding Biological Mechanisms: Using Illustrations from Circadian Rhythm Research [PDF]

, 2012
In many fields of biology, researchers explain a phenomenon by characterizing the responsible mechanism. This requires identifying the candidate mechanism, decomposing it into its parts and operations, recomposing it so as to understand how it is ...
Bechtel, William
core  

The diagnostic value of the circadian rhythm gene KLF10 in anxiety‐depressive disorders and its neuroimmune regulatory mechanisms

Animal Models and Experimental Medicine, EarlyView.
This graphical abstract illustrates the protective role and molecular mechanism of the circadian rhythm‐related gene KLF10, identified as a diagnostic biomarker and therapeutic target in anxiety‐depressive disorder. Model establishment and phenotypes: An anxiety‐depression model was successfully established by chronic restraint stress combined with ...
Anlan Liu, Weifeng Guo, Jianxiang Li, Tiange Zhang, Dan Xu   +4 more
wiley   +1 more source

The hormonal Zeitgeber melatonin: role as a circadian modulator in memory processing [PDF]

, 2012
The neuroendocrine substance melatonin is a hormone synthesized rhythmically by the pineal gland under the influence of the circadian system and alternating light/dark cycles. Melatonin has been shown to have broad applications, and consequently becoming
Rawashdeh, Oliver, Erik Maronde, Maronde, Erik, Oliver eRawashdeh, Erik eMaronde, Oliver Rawashdeh   +5 more
core   +1 more source

In Silico to In Cerebro—Development of the Orexin Receptor Antagonist “Photorexant” for Photomodulation In Vitro and in Mouse Brains

Angewandte Chemie International Edition, EarlyView.
Following a structure‐based design approach, photoswitchable derivatives of the FDA‐approved drug suvorexant were designed, docked, synthesized, and characterized pharmacologically at the orexin 1 and 2 receptors (OX1R and OX2R). Optimized “photorexant” showed up to an 11‐fold difference in IC50 between photoisomers, enabled dynamic and reversible ...
Marcus Angermann, Marie H. Deventer, Vicente Ledesma‐Martin, Nuno Martinho, Alix Flake, Silvia Mori, Angel Nuñez, Jaime Pignatelli, Rita C. Guedes, Christophe P. Stove, Michael Decker   +10 more
wiley   +1 more source

Gut Health in Ostriches (Struthio camelus): Insights Into Intestinal Structure, Functions, Microbiome, and Improvement Strategies

Animal Research and One Health, EarlyView.
Our paper systematically reviews the intestinal structure, function, and microbiota of ostriches, along with strategies for improving their gut health. We analyze how these factors collectively influence intestinal homeostasis and ostrich welfare, emphasizing probiotics as a promising intervention to enhance gut health, boost population well‐being, and
Zi‐Qun Zhang, Fang‐Fang Guo, Wen‐Juan Du, Meng Li, Aftab Shaukat, Zhu‐Qing Jia, Shu‐Cheng Huang   +6 more
wiley   +1 more source