Results 81 to 90 of about 213,878 (305)

Biological clocks in theory and experiments [PDF]

, 2005
Eukaryotes and some prokaryotes have adapted to the 24 h day/night cycle by evolving circadian clocks. The circadian clock now controls 24-hour rhythms in very many aspects of metabolism, physiology and behaviour.
Andrew J Millar, Millar Andrew J, Millar, Andrew; id_orcid   +2 more
core   +1 more source

Developmental Environmental Chronotoxicity by Polystyrene Nanoplastics Exacerbates High‐Fat Diet‐Induced Pediatric MAFLD Through Circadian Disruption and Mitochondrial Dysfunction

Advanced Science, EarlyView.
Polystyrene nanoplastics exacerbate high‐fat diet‐induced metabolic dysfunction in an age‐dependent manner. Juvenile mice exhibit greater susceptibility, characterized by circadian disruption, impaired mitochondrial function, reduced energy metabolism, and enhanced hepatic lipid accumulation.
Peihao Xu, Shuting Huang, Leilei Zhu, Junyi Huang, Kewei Li, Guangming Li, Jiannong Wu, Mingyuan Zhou, Fangmei Zhou, Zhishan Ding, Yingzhi Shen   +10 more
wiley   +1 more source

Development of circadian oscillators in neurosphere cultures during adult neurogenesis.

PLoS ONE, 2015
Circadian rhythms are common in many cell types but are reported to be lacking in embryonic stem cells. Recent studies have described possible interactions between the molecular mechanism of circadian clocks and the signaling pathways that regulate stem ...
Astha Malik, Roudabeh J Jamasbi, Roman V Kondratov, Michael E Geusz   +3 more
doaj   +1 more source

Retinal circadian rhythms in mammals revealed using electroretinography

, 2013
Light levels can change by up to ten orders of magnitude between midday and midnight. As a result, the visual system is faced with a large diurnal variation in functional demands.
Allen, Annette E.; id_orcid, Cameron, Morven A., Lucas, Robert J.; id_orcid, Allen, Annette E., Annette E. Allen, Robert J. Lucas, Cameron, Morven A. (R16611), Morven A. Cameron, Lucas, Robert J.   +8 more
core   +1 more source

The contributions of interlocking loops and extensive nonlinearity to the properties of circadian clock models [PDF]

, 2010
Sensitivity and robustness are essential properties of circadian clock systems, enabling them to respond to the environment but resist noisy variations. These properties should be recapitulated in computational models of the circadian clock.
Andrew J Millar, Painter, Kevin J., Saithong Treenut, Saithong T., Painter K. J., Painter Kevin J., Saithong, Treenut, Kevin J Painter, Millar Andrew J., Andrew J. Millar, Millar A. J., Millar, Andrew J; id_orcid, Treenut Saithong, Painter, Kevin J, Millar, Andrew J., Kevin J. Painter   +15 more
core   +1 more source

Blue Light Receptor PHR2‐Mediated Spectrum Antiviral Immunity

Advanced Science, EarlyView.
Blue light suppresses RBSDV through the blue‐light receptor ZmPHR2, which interacts with ZmISP in chloroplasts to trigger ROS burst and antiviral defense. The viral effector P6 enhances ZmPHR2–ZmISP interaction, alters their distribution, and suppresses ROS.
Runyi Chen, Yuxin Tai, Xinyu Wang, Chunhua Mu, Xia Liu, Gongjian Li, Jiayi Liu, Xin Lu, Duo Shi, Zhiqiang Zhou, Jienan Han, Zhuanfang Hao, Mingshun Li, Degui Zhang, Hongjun Yong, Zhennan Xu, Jianfeng Weng, Xinhai Li   +17 more
wiley   +1 more source

Melatonin Mitigates Doxorubicin‐Induced Cardiotoxicity by Targeting the USP18/PKM2 Axis Without Compromising Antitumor Efficacy

Advanced Science, EarlyView.
Melatonin engages MT1/MT2 receptors to suppress STAT1‐driven USP18 upregulation, thereby redirecting PKM2 ubiquitination from K33‐linked autophagic degradation toward K27‐linked nuclear translocation. This prevents PKM2‐mediated proinflammatory gene expression in the heart, alleviating doxorubicin‐induced cardiotoxicity without compromising antitumor ...
Zhenyu Feng, Yijin Yang, Jie Bai, Pengqi Sun, Xuyang Sun, Jinshu Shang, Yang Liu, Zhen Ning, Ningning Zhang, Yun‐long Xia, Yunpeng Xie   +10 more
wiley   +1 more source

Therapeutic Aspects of Circadian Rhythms

, 2023
Circadian rhythms are ubiquitous endogenous rhythms with a period of approximately twenty-four hours [...
Randy J. Nelson, James C. Walton
core   +1 more source

Blocking Honeybee Preference for Neonicotinoids by Interfering With Dopamine Signaling

Advanced Science, EarlyView.
Honeybees (Apis mellifera) paradoxically prefer nectar containing the harmful neonicotinoid thiamethoxam. This preference is associated with transient brain dopamine elevation during proboscis extension reflex (PER) responses and active feeding, and is reduced by the dopamine receptor antagonist fluphenazine.
Jing Li, Yuan Ge, Wangjiang Feng, David C. Lyon, Pingli Dai, Yong‐Jun Liu   +5 more
wiley   +1 more source

Intracellular potassium levels orchestrate circadian rhythmicity and cell division

Nature Communications
Circadian (~24 h) rhythms are a fundamental feature of life, and their disruption increases the risk of infectious diseases, metabolic disorders, and cancer.
Sergio Gil Rodríguez, Louise L. Hansen, Olivia J. P. Fraser, Yen Peng Chew, Rebecca K. Spangler, Ellen Grünewald, Andrew D. Beale, Beverley M. Rabbitts, Alessandra Stangherlin, John S. O’Neill, Carrie L. Partch, Priya Crosby, Gerben van Ooijen   +12 more
doaj   +1 more source