Results 81 to 90 of about 206,395 (302)

FLOWERING LOCUS C -dependent and -independent regulation of the circadian clock by the autonomous and vernalization pathways [PDF]

, 2006
Background The circadian system drives pervasive biological rhythms in plants. Circadian clocks integrate endogenous timing information with environmental signals, in order to match rhythmic outputs to the local day/night cycle.
Salathia Neeraj, Andrew J Millar, Amasino, R., Michaels, Scott D, Lynn, J., Millar Andrew J, Millar, A., Lynn, James R, Davis, S. J., Lynn, J. R., Michaels, Scott D., Amasino Richard M, Davis, Seth J., Salathia, N., Millar, A. J., Lynn James R, Lynn, James R., Neeraj Salathia, Davis, Seth J, Michaels Scott D, Richard M Amasino, Amasino, Richard M., Davis, S., Michaels, S. D., Amasino, Richard M, Amasino, R. M., Michaels, S., Seth J Davis, Davis Seth J, Millar, Andrew J; id_orcid, Millar, A. J. (Andrew J.), Scott D Michaels, Salathia, Neeraj, James R Lynn   +33 more
core   +1 more source

Targeting the NR1D1–IGF2BP2–V‐ATPase Axis With Hybrid Nanovesicles Restores Macrophage Rhythms to Reverse Sepsis‐Induced Immunosuppression

Advanced Science, EarlyView.
Sepsis disrupts immune‐cell rhythms and weakens bacterial clearance. Biomimetic nanovesicles combining erythrocyte and inflammation‐activated macrophage membranes deliver siNR1D1 to dysfunctional macrophages, restoring the NR1D1–IGF2BP2–V‐ATPase pathway, circadian regulation, phagolysosomal acidification, and antimicrobial defense.
Lang Chen, Wenyi Lin, Lang Jiang, Xuehui Gao, Chenyan Yu, Jili Han, Zhenping Liu, Xuefeng Li, Mei He, Chang Li, Qilan Li, Chaoying Song, Jiqian Xu, You Shang   +13 more
wiley   +1 more source

Development of circadian oscillators in neurosphere cultures during adult neurogenesis.

PLoS ONE, 2015
Circadian rhythms are common in many cell types but are reported to be lacking in embryonic stem cells. Recent studies have described possible interactions between the molecular mechanism of circadian clocks and the signaling pathways that regulate stem ...
Astha Malik, Roudabeh J Jamasbi, Roman V Kondratov, Michael E Geusz   +3 more
doaj   +1 more source

Disruption of rhythms of molecular clocks in primary synovial fibroblasts of patients with osteoarthritis and rheumatoid arthritis, role of IL-1;2/TNF [PDF]

, 2012
Introduction: Circadian rhythms play an important role in the body and in single cells. Rhythms of molecular clocks have not been investigated in synovial fibroblasts (SF) of patients with osteoarthritis (OA) and rheumatoid arthritis (RA).
Haas, Stefanie, Stefanie Haas, Rainer H Straub, Straub, Rainer H.   +3 more
core   +1 more source

Spatiotemporal Multi‐Omic Mapping Reveals Liver‐Muscle Metabolic Crosstalk in Cancer Cachexia

Advanced Science, EarlyView.
The interactive CCAtlas platform delineates cross‐species, spatiotemporal, and sex‐specific molecular dynamics and metabolic rewiring across organs during cancer cachexia. Hepatic Gamt downregulation curtails hepatic creatine synthesis to trigger systemic creatine insufficiency and consequent skeletal muscle atrophy in LLC tumour‐bearing mice ...
Zihan Tian, Qianyu Wang, Wenyan Gao, Xianfeng Li, Jiawen Fan, Xiaoliang Wu, Siqi Liu, Xiangdong Ming, Danna Yeerken, Mutian Shen, Qingjie Min, Qimin Zhan, Yan Wang   +12 more
wiley   +1 more source

A Circadian Clock-Regulated Toggle Switch Explains AtGRP7 and AtGRP8 Oscillations in Arabidopsis thaliana [PDF]

, 2013
Schmal C, Reimann P, Staiger D. A Circadian Clock-Regulated Toggle Switch Explains AtGRP7 and AtGRP8 Oscillations in Arabidopsis thaliana. PLoS Computational Biology. 2013;9(3): e1002986.The circadian clock controls many physiological processes in higher
Staiger Dorothee, Peter Reimann, Reimann, Peter, Schmal, Christoph, Dorothee Staiger (40787), Christoph Schmal, Schmal Christoph, Reimann Peter, Peter Reimann (395937), Staiger, Dorothee, Dorothee Staiger, Christoph Schmal (395936)   +11 more
core   +1 more source

Tumor Exposomics: A New Paradigm for Individualized Continuous Exposure Monitoring

Advanced Science, EarlyView.
Tumor exposomics integrates continuous monitoring of environmental exposures, endogenous biological responses, and behavioral factors within a unified temporal framework. By combining multimodal sensing technologies with AI‐enabled causal modeling, this emerging paradigm reconstructs exposure‐damage trajectories and supports individualized dynamic risk
Kaicheng Shen, Weiyi Wang, Yang Wang, Yiqiang Wu, Xiaohong Liu, Wei Zhang, Juanjuan Ou   +6 more
wiley   +1 more source

Circadian‐Inspired Hydrogel Moisture Electricity Generation

Advanced Science, EarlyView.
A circadian‐inspired hydrogel moisture‐electric generator enables sustainable electricity generation by autonomously current direction switching between daytime and nighttime. This reversible output is accompanied by inversion of the internal water gradient, which effectively reduce hydrogel fatigue and offers a new strategy for harvesting diurnal ...
Ziqi Li, Dilalanmu Ahemaitijiang, Hongfei Yang, Xuan Zhao, Mengjiao Pan, Jun Wan, Pingan Zhu, Dahua Shou   +7 more
wiley   +1 more source

Intracellular potassium levels orchestrate circadian rhythmicity and cell division

Nature Communications
Circadian (~24 h) rhythms are a fundamental feature of life, and their disruption increases the risk of infectious diseases, metabolic disorders, and cancer.
Sergio Gil Rodríguez, Louise L. Hansen, Olivia J. P. Fraser, Yen Peng Chew, Rebecca K. Spangler, Ellen Grünewald, Andrew D. Beale, Beverley M. Rabbitts, Alessandra Stangherlin, John S. O’Neill, Carrie L. Partch, Priya Crosby, Gerben van Ooijen   +12 more
doaj   +1 more source

Robustness from flexibility in the fungal circadian clock [PDF]

, 2010
Background Robustness is a central property of living systems, enabling function to be maintained against environmental perturbations. A key challenge is to identify the structures in biological circuits that confer system-level properties such as ...
Andrew J Millar, Paul E Brown, David A Rand, Akman, Ozgur E., Rand, D. A. (David A.), Akman, Ozgur E, Brown, Paul E, Rand, David A., Ozgur E Akman, Millar, Andrew J; id_orcid, Brown, Paul E., Millar, A. J. (Andrew J.), Millar, Andrew J., Rand, David A   +13 more
core   +1 more source