Results 61 to 70 of about 206,395 (302)

The Neurobiology of Circadian Rhythms

Psychiatric Clinics of North America, 2015
There is a growing recognition that the coordinated timing of behavioral, physiologic, and metabolic circadian rhythms is a requirement for a healthy body and mind. In mammals, the primary circadian oscillator is the hypothalamic suprachiasmatic nucleus (SCN), which is responsible for circadian coordination throughout the organism. Temporal homeostasis
Sollars, Patricia J., Pickard, Gary E.
openaire   +3 more sources

Circadian rhythms and diabetes [PDF]

Journal of Diabetes Investigation, 2011
All free‐living organisms are regulated by the 24‐h light and dark cycle produced by Earth’s rotation. In mammals, circadian rhythms are indispensble for the regulation of physiological and biochemical processes in the body. In 1972, the suprachiasmatic nucleus was shown to be required for daily rhythms in animal behavior1.
Kurose, Takeshi, Yabe, Daisuke, Inagaki, Nobuya   +2 more
openaire   +2 more sources

Hierarchically coupled ultradian oscillators generating robust circadian rhythms [PDF]

, 1997
Ensembles of mutually coupled ultradian cellular oscillators have been proposed by a number of authors to explain the generation of circadian rhythms in mammals.
Maini, P. K., Barrio, R. A., Zhang, L., Zhang, L, Maini, Philip, Maini, PK, Barrio, RA   +6 more
core   +1 more source

Psychological Stress Associated Bile Acid Reprogramming Promotes Hepatocellular Carcinoma Progression

Advanced Science, EarlyView.
Depression is increasingly recognized as a risk factor for chronic diseases, yet its biological impact on cancer remains unclear. Using data from more than 490 000 participants across three international cohorts, we show that depression significantly increases the risk of liver cancer.
Ruijiang Zeng, Mengmeng Wang, Kang Wang, Zhuo Xing, Yulong Hong, Tongtong Li, Geng Zong, Chong Yang, Dan Zhang, Zhangling Chen, Xin Jin   +10 more
wiley   +1 more source

Pathophysiological Models of Hypersomnolence Associated With Depression

Biological Psychiatry Global Open Science
Up to 25% of patients with depression experience hypersomnolence (e.g., excessive daytime sleepiness, hypersomnia, and/or sleep inertia), which is associated with treatment resistance, overall poorer outcomes, and safety concerns while driving ...
Christophe Moderie, Diane B. Boivin
doaj   +1 more source

Mechanism for 12 Hr Rhythm Generation by the Circadian Clock

Cell Reports, 2013
In addition to the well-known circadian rhythms in animal behavior, cell biology, and gene expression, there are also 12 hr rhythms. The mechanism giving rise to these 12 hr rhythms is not clear.
Pål O. Westermark, Hanspeter Herzel
doaj   +1 more source

Aging and circadian rhythms [PDF]

Current Opinion in Insect Science, 2015
Circadian clocks are cell-autonomous molecular feedback loops that generate daily rhythms in gene expression, cellular functions, physiological processes and behavior. The mechanisms of circadian clocks are well understood in young fruit flies Drosophila melanogaster, but less is known about how circadian system changes during organismal aging. Similar
Jadwiga M, Giebultowicz, Dani M, Long
openaire   +2 more sources

Watching the hands of the Arabidopsis biological clock [PDF]

, 2001
Oligonucleotide and cDNA microarrays have been used to analyse the mRNA levels of 8,000 genes in Arabidopsis thaliana throughout the day/night cycle. Genes involved in signal transduction and in various metabolic pathways were found to be coordinately ...
Davis, Seth J., Davis, S J, Millar, A. J. (Andrew J.), Millar, A J; id_orcid   +3 more
core   +1 more source

HD‐tDCS Restores Perivascular AQP4 Polarization via PPARγ Modulation to Enhance Glymphatic Clearance After Intracerebral Hemorrhage in Mice

Advanced Science, EarlyView.
HD‐tDCS promotes recovery after intracerebral hemorrhage by enhancing PPARγ‐dependent astrocyte remodeling in a mouse model of ICH. This process suppresses proinflammatory astrocytic activation, restores perivascular AQP4 repolarization, and improves glymphatic influx and efflux, thereby facilitating hematoma and perihematomal edema clearance and ...
Zhiming Li, Yingmei Zhang, Qianqian Tong, Zhitao Gong, Shanyu Zhang, Zhen Qian, Hui Zhang, Qian Yao, Qi Li   +8 more
wiley   +1 more source

Polymorphisms in the circadian expressed genes PER3 and ARNTL2 are associated with diurnal preference and GNβ3 with sleep measures [PDF]

, 2014
Sleep and circadian rhythms are intrinsically linked, with several sleep traits, including sleep timing and duration, influenced by both sleep homeostasis and the circadian phase.
Lester, Kathryn, Lester, KJ, Archer, Simon, Archer, SN, Gregory, Alice M, Lester, Kathryn J., Barclay, Nicola L., Gregory, Alice, Nolan, Patrick M., Nolan, PM, Nolan, Patrick, Parsons, Michael J., Eley, Thalia C, Archer, Simon N., Barclay, Nicola, Gregory, AM, Patrick M Nolan (11641339), Barclay, Nicola L, Eley, Thalia C., Nolan, Patrick M, Archer, Simon N, Parsons, Michael J, Kathryn Lester (4462210), Nicola L Barclay (16221641), Parsons, Michael, Thalia C Eley (13615696), Parsons, MJ, Eley, Thalia, Simon N Archer (16221644), Alice M Gregory (11992776), Lester, Kathryn J, Michael J Parsons (16221638), Gregory, Alice M., Eley, TC, Barclay, NL   +34 more
core   +1 more source