Results 51 to 60 of about 143,667 (304)

Tissue‐Stimulator Platform for Electrically Stimulating Pancreatic β‐Cells for Long‐Term Functional Regulation

Advanced Functional Materials, EarlyView.
We present a tissue‐stimulator platform for seamless electrode integration with pancreatic tissue, applying uniform electrical stimulation through optimized design with biohybrid 3D printing. Advantageous effects of electrical stimulation on β‐cell function were observed, including enhanced calcium signaling, islet morphology, and maturation.
Jihwan Kim, Uijung Yong, Myungji Kim, Jaewook Kim, Yeonggwon Jo, In Kyong Shim, Song Cheol Kim, Jinah Jang   +7 more
wiley   +1 more source

Inhibition of REV-ERBs stimulates microglial amyloid-beta clearance and reduces amyloid plaque deposition in the 5XFAD mouse model of Alzheimer\u27s disease [PDF]

, 2020
A promising new therapeutic target for the treatment of Alzheimer\u27s disease (AD) is the circadian system. Although patients with AD are known to have abnormal circadian rhythms and suffer sleep disturbances, the role of the molecular clock in ...
Griffin, Percy, Kim, Do Eon, Kim, Dong-Hou, Lee, Jiyeon, Musiek, Erik S, Sheehan, Patrick W, Yoon, Seung-Yong   +6 more
core   +1 more source

Timing of host feeding drives rhythms in parasite replication [PDF]

, 2018
Circadian rhythms enable organisms to synchronise the processes underpinning survival and reproduction to anticipate daily changes in the external environment.
Abhinay Ramaprasad, Aidan J. O’Donnell, AJ O’Donnell, AJ O’Donnell, AM Curtis, Amit Subudhi, Arnab Pain, AS Bell, C Scheiermann, CT Hotta, D Acuña-Castroviejo, D Kwiatkowski, D Luna-Moreno, Daan R. van der Veen, David Schneider, DJ Cheon, DJ Kennaway, DR van der Veen, DR van der Veen, E N’Goran, EN Brown, ES Nasset, F Damiola, F Hawking, F Hawking, F Hawking, F Rijo-Ferreira, G Cambie, GH Boyd, GR McGinnis, IM Rouzine, J Chao, J Laermans, JA Mohawk, JI Blanford, JI MacRae, JL Wright, JM Orengo, K Artavanis-Tsakonas, K Matsukawa, K Stokkan, Katherine Cumnock, KD Nguyen, KF Prior, Kimberley F. Prior, L Mancio-Silva, LM Kumaratilake, Luisa Figueiredo, M Cuesta, M Goto, M Martinez-Bakker, MA Hevia, MM Stevenson, N Le Minh, N Mideo, N Regev-Rudzki, Nicholas J. Savill, OV Dolnik, P Gautret, P Jacobs, PE Hardin, PH David, RC Salgado-Delgado, RJ Christopherson, S Benloucif, Samuel S. C. Rund, Sarah E. Reece, SD Jordan, SE Reece, SJ Glastras, SMT Wehrens, SMW Rajaratnam, SMW Rajaratnam, T Brugat, T Roenneberg, TA Bargiello, U Albrecht, VK Sharma, Y Adamovich, Y Yasumoto   +79 more
core   +3 more sources

Recapitulating Endochondral Ossification for Bone Repair: From Development to Engineering Strategy

Advanced Healthcare Materials, EarlyView.
This review summarizes the developmental basis of endochondral ossification (ECO) and its applications in bone tissue engineering (BTE). It first outlines the key biological processes and signaling pathways underlying ECO, then discusses biomaterial‐based engineering strategies derived from these principles, and finally highlights future directions for
Yiqi Su, Zihao He, Qianqian Chen, Long Chen, Caiyi Wei, Zijin Zhou, Jianhao Lin, Hui Li, Dan Xing   +8 more
wiley   +1 more source

Mechanism for 12 Hr Rhythm Generation by the Circadian Clock

Cell Reports, 2013
In addition to the well-known circadian rhythms in animal behavior, cell biology, and gene expression, there are also 12 hr rhythms. The mechanism giving rise to these 12 hr rhythms is not clear.
Pål O. Westermark, Hanspeter Herzel
doaj   +1 more source

Vasoactive intestinal polypeptide mediates circadian rhythms in Mammalian olfactory bulb and olfaction [PDF]

, 2014
Accumulating evidence suggests that the olfactory bulbs (OBs) function as an independent circadian system regulating daily rhythms in olfactory performance.
Granados-Fuentes, Daniel, Herzog, Erik D, Holy, Timothy E, Marpegan, Luciano, Miller, Jae-eun, Wang, Thomas   +5 more
core   +2 more sources

Microfluidic Engineering of Chitosan‐Coated Nanoemulsions for Controlled Release and Stability in Space Pharmaceutics

Advanced Materials Technologies, EarlyView.
Microfluidic engineering enables the fabrication of chitosan‐coated, melatonin‐loaded nanoemulsions with controlled release and enhanced physicochemical stability for space pharmaceutics. Interfacial biopolymer coating modulates droplet behavior under accelerated thermal stress and simulated microgravity.
Modupe Adebowale, Nguyen Van Duc Long, Philip M Williams, Volker Hessel   +3 more
wiley   +1 more source

Pathophysiological Models of Hypersomnolence Associated With Depression

Biological Psychiatry Global Open Science
Up to 25% of patients with depression experience hypersomnolence (e.g., excessive daytime sleepiness, hypersomnia, and/or sleep inertia), which is associated with treatment resistance, overall poorer outcomes, and safety concerns while driving ...
Christophe Moderie, Diane B. Boivin
doaj   +1 more source

Circadian and Metabolic Effects of Light: Implications in Weight Homeostasis and Health [PDF]

, 2017
Daily interactions between the hypothalamic circadian clock at the suprachiasmatic nucleus (SCN) and peripheral circadian oscillators regulate physiology and metabolism to set temporal variations in homeostatic regulation.
Diego A. Golombek, Juan J. Chiesa, Leandro P. Casiraghi, Natalia Paladino, Paula García Moro, Santiago A. Plano, Santiago A. Plano   +6 more
core   +2 more sources

Paternal Circadian Disruption Impairs Offspring Cognition via Sperm microRNAs

Advanced Science, EarlyView.
Paternal circadian disruption remodels the sperm small RNA payload, elevating miR‐92a‐3p/miR‐25‐3p levels and perturbing early embryonic gene regulatory programs. Microinjection experiments and single‐embryo transcriptomics reveal sex‐specific developmental vulnerabilities, ultimately impairing offspring hippocampal synaptic plasticity and cognition ...
Kexin Zou, Sisi Luo, Binliang Tang, Zhiqiang Liu, Yuchuan Zhou, Yicong Meng, Zhengmu Wu, Zheng Sun, Weihui Shi, Jianzhong Sheng, Chuanjin Yu, Zhenhua Li, Siyi Wei, Mo Zhang, Yujie Luo, Jing Yan, Xueyun Qin, Jiahang Mo, Chengliang Zhou, Jinsong Li, Hefeng Huang, Yifu Ding, Guolian Ding   +22 more
wiley   +1 more source