Results 41 to 50 of about 206,395 (302)
Journal of the American Heart Association: Cardiovascular and Cerebrovascular DiseaseBackground Cardiovascular vascular disease (CVD) is a leading cause of increased mortality in people with severe mental illness (SMI). This study aims to examine the dose–response and intensity‐specific associations between physical activity (PA) and CVD
Jing Du +9 more
doaj +1 more source
Circadian rhythm and neurodegenerative disorders
Brain Science Advances, 2020 The circadian clock controls daily rhythms in animal physiology, metabolism, and behavior, such as the sleep‐wake cycle. Disruption of circadian rhythms has been revealed in many diseases including neurodegenerative disorders.
Michelle Werdann, Yong Zhang
doaj +1 more source
Circadian Rhythms in Cyanobacteria [PDF]
Microbiology and Molecular Biology Reviews, 2015 SUMMARY Life on earth is subject to daily and predictable fluctuations in light intensity, temperature, and humidity created by rotation of the earth. Circadian rhythms, generated by a circadian clock, control temporal programs of cellular physiology to facilitate adaptation to daily environmental changes.
Cohen, Susan E, Golden, Susan S
openaire +4 more sources
Adult Circadian behavior in Drosophila requires developmental expression of cycle, but not period [PDF]
, 2011 Circadian clocks have evolved as internal time keeping mechanisms that allow anticipation of daily environmental changes and organization of a daily program of physiological and behavioral rhythms.
Bonilla Gloribel +21 more
core +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
The Role of TASK-3 Two-Pore Domain Potassium Channels in the Entrainment of Mammalian Circadian Rhythms [PDF]
, 2014 In mammals light is the principal timing cue for alignment of physiology to the external environment. Illumination from the unrelenting 24-hour day-night cycle enters the biological system and is communicated to the master pacemaker, the suprachiasmatic
Atkinson, Lynsey A
core
Global parameter search reveals design principles of the mammalian circadian clock [PDF]
, 2008 Background: Virtually all living organisms have evolved a circadian (~24 hour) clock that controls physiological and behavioural processes with exquisite precision throughout the day/night cycle.
Locke, James C. W. +3 more
core +1 more source
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
Circadian rhythmicity and light sensitivity of the zebrafish brain [PDF]
, 2013 Light is important for entraining circadian rhythms, which regulate a wide range of biological processes. Zebrafish have directly light responsive tissues (Whitmore et al 2000) and are thus a useful vertebrate model for circadian rhythmicity and light ...
Moore, HA
core
The Input Signal Step Function (ISSF), a Standard Method to Encode Input Signals in SBML Models with Software Support, Applied to Circadian Clock Models [PDF]
, 2012 Time-dependent light input is an important feature of computational models of the circadian clock. However, publicly available models encoded in standard representations such as the Systems Biology Markup Language (SBML) either do not encode this input ...
Adams, RR +11 more
core +1 more source