Results 41 to 50 of about 213,878 (305)

Circadian rhythms and diabetes [PDF]

Journal of Diabetes Investigation, 2011
All free‐living organisms are regulated by the 24‐h light and dark cycle produced by Earth’s rotation. In mammals, circadian rhythms are indispensble for the regulation of physiological and biochemical processes in the body. In 1972, the suprachiasmatic nucleus was shown to be required for daily rhythms in animal behavior1.
Kurose, Takeshi, Yabe, Daisuke, Inagaki, Nobuya   +2 more
openaire   +2 more sources

FLOWERING LOCUS C -dependent and -independent regulation of the circadian clock by the autonomous and vernalization pathways [PDF]

, 2006
Background The circadian system drives pervasive biological rhythms in plants. Circadian clocks integrate endogenous timing information with environmental signals, in order to match rhythmic outputs to the local day/night cycle.
Salathia Neeraj, Andrew J Millar, Amasino, R., Michaels, Scott D, Lynn, J., Millar Andrew J, Millar, A., Lynn, James R, Michaels, Scott D., Amasino Richard M, Davis, Seth J., Salathia, N., Lynn James R, Lynn, James R., Neeraj Salathia, Davis, Seth J, Michaels Scott D, Richard M Amasino, Amasino, Richard M., Davis, S., Amasino, Richard M, Michaels, S., Seth J Davis, Davis Seth J, Millar, Andrew J; id_orcid, Millar, A. J. (Andrew J.), Scott D Michaels, Salathia, Neeraj, James R Lynn   +28 more
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Association of Accelerometer‐Derived Physical Activity with Incident Cardiovascular Diseases and Mortality in People With Severe Mental Illness

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Cardiovascular vascular disease (CVD) is a leading cause of increased mortality in people with severe mental illness (SMI). This study aims to examine the dose–response and intensity‐specific associations between physical activity (PA) and CVD
Jing Du, Xingya Lei, Qiang Wang, Hongliang Feng, Zezhi Li, Ruizhi Zhang, Yaping Liu, Jihui Zhang, Yujing Zhou, Yannis Yan Liang   +9 more
doaj   +1 more source

Programming effects of maternal stress on the circadian system of adult offspring

Experimental and Molecular Medicine, 2020
Circadian rhythms: Maternal stress can disrupt adult offspring’s biological clock When pregnant mothers are stressed, the fetus’s circadian rhythms are reprogrammed, increasing the risk of health complications later in life.
Seongsik Yun, Eun Jeong Lee, Han Kyoung Choe, Gi Hoon Son, Kyungjin Kim, Sooyoung Chung   +5 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Conditional circadian regulation of PHYTOCHROME A gene expression [PDF]

, 2001
The phytochrome photoreceptors and the circadian clock control many of the same developmental processes, in all organs and throughout the growth of Arabidopsis plants. Phytochrome A (phyA) provides light input signals to entrain the circadian clock.
Nagy, F, Hall, Anthony, Kozma-Bognár, L, Tóth, R, Millar, A J; id_orcid   +4 more
core   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Genetics of Circadian Rhythms

Neurologic Clinics, 2019
In mammals, genetic influences of circadian rhythms occur at many levels. A set of core "clock genes" have been identified that form a feedback loop of gene transcription and translation. The core genetic clockwork generates circadian rhythms in cells throughout the body.
Martha Hotz, Vitaterna, Kazuhiro, Shimomura, Peng, Jiang   +2 more
openaire   +3 more sources

Circadian rhythms in RA [PDF]

Annals of the Rheumatic Diseases, 2003
Possible roles of cortisol and melatonin It is well known that some clinical signs and symptoms of rheumatoid arthritis (RA) vary within a day and between days, and the morning stiffness seen in patients with RA has become one of the diagnostic criteria of the disease (fig 1).1 Figure 1 Clinical signs and symptoms of articular inflammation in ...
CUTOLO, MAURIZIO, SERIOLO, BRUNO, Craviotto C, PIZZORNI, CARMEN, SULLI, ALBERTO   +4 more
openaire   +3 more sources