Diurnal rhythms in neurexins transcripts and inhibitory/excitatory synapse scaffold proteins in the biological clock [PDF]
, 2012 The neurexin genes (NRXN1/2/3) encode two families (α and β) of highly polymorphic presynaptic proteins that are involved in excitatory/inhibitory synaptic balance.
Hendricks, Michael +15 more
core +1 more source
Biology Open, 2019 Glioblastoma (GBM) is the most prevalent type of primary brain tumor. Treatment options include maximal surgical resection and drug-radiotherapy combination.
Luis A. Vargas-Patron +6 more
doaj +1 more source
A cellular model for human daily behaviour [PDF]
, 2010 All the biochemical, physiological or behavioural processes whose period is about 24 hours possess a circadian rhythm. In mammals circadian rhythms control almost all aspects of human daily behaviour and physiology.
Pagani, Lucia
core +1 more source
Postnatal constant light compensates Cryptochrome1 and 2 double deficiency for disruption of circadian behavioral rhythms in mice under constant dark. [PDF]
PLoS ONE, 2013 Clock genes Cryptochrome (Cry1) and Cry2 are essential for expression of circadian rhythms in mice under constant darkness (DD). However, circadian rhythms in clock gene Per1 expression or clock protein PER2 are detected in the cultured suprachiasmatic ...
Daisuke Ono, Sato Honma, Ken-Ichi Honma
doaj +1 more source
Metals and Circadian Rhythms [PDF]
, 2017 Circadian rhythms describe the behavioral and physiological changes that occur in living organisms in order to attune to a 24 hour cycle of day and night. The most striking aspect of circadian function is the sleep-wake cycle, however many other physiological processes are regulated in 24 hour oscillations, including blood pressure, body temperature ...
Nancy L, Parmalee, Michael, Aschner
openaire +2 more sources
Global parameter search reveals design principles of the mammalian circadian clock [PDF]
, 2008 Background: Virtually all living organisms have evolved a circadian (~24 hour) clock that controls physiological and behavioural processes with exquisite precision throughout the day/night cycle.
Locke, James C. W. +3 more
core +1 more source
The Input Signal Step Function (ISSF), a Standard Method to Encode Input Signals in SBML Models with Software Support, Applied to Circadian Clock Models [PDF]
, 2012 Time-dependent light input is an important feature of computational models of the circadian clock. However, publicly available models encoded in standard representations such as the Systems Biology Markup Language (SBML) either do not encode this input ...
Adams, RR +11 more
core +1 more source
Programming effects of maternal stress on the circadian system of adult offspring
Experimental and Molecular Medicine, 2020 Circadian rhythms: Maternal stress can disrupt adult offspring’s biological clock When pregnant mothers are stressed, the fetus’s circadian rhythms are reprogrammed, increasing the risk of health complications later in life.
Seongsik Yun +5 more
doaj +1 more source
Circadian Rhythms in Immunity [PDF]
Current Allergy and Asthma Reports, 2020 This review is focused on the existing evidence for circadian control of innate and adaptive immune responses to provide a framework for evaluating the contributions of diurnal rhythms to control of infections and pathogenesis of disease.Circadian rhythms driven by cell-autonomous biological clocks are central to innate and adaptive immune responses ...
openaire +2 more sources
Circadian rhythm and neurodegenerative disorders
Brain Science Advances, 2020 The circadian clock controls daily rhythms in animal physiology, metabolism, and behavior, such as the sleep‐wake cycle. Disruption of circadian rhythms has been revealed in many diseases including neurodegenerative disorders.
Michelle Werdann, Yong Zhang
doaj +1 more source