Results 21 to 30 of about 143,667 (304)

Uncoupling the Mitogenic and Metabolic Functions of FGF1 by Tuning FGF1-FGF Receptor Dimer Stability

Cell Reports, 2017
Lysine acetylation is involved in various biological processes and is considered a key reversible post-translational modification in the regulation of gene expression, enzyme activity, and subcellular localization. This post-translational modification is
Zhifeng Huang, Florian Atger, Loïc Dayon, Antonio Núñez Galindo, Jingkui Wang, Eva Martin, Laetitia Da Silva, Ivan Montoliu, Sebastiano Collino, Francois-Pierre Martin, Joanna Ratajczak, Carles Cantó, Martin Kussmann, Felix Naef, Frédéric Gachon   +14 more
doaj   +1 more source

Circadian rhythms and hormonal homeostasis: Pathophysiological implications [PDF]

, 2017
Over recent years, a deeper comprehension of the molecular mechanisms that control biological clocks and circadian rhythms has been achieved. In fact, many studies have contributed to unravelling the importance of the molecular clock for the regulation ...
Bruscalupi, Giovannella, Gnocchi, Davide
core   +2 more sources

Dopamine 2 Receptor Activation Entrains Circadian Clocks in Mouse Retinal Pigment Epithelium

Scientific Reports, 2017
Many of the physiological, cellular, and molecular rhythms that are present within the eye are under the control of circadian clocks. Experimental evidence suggests that the retinal circadian clock, or its output signals (e.g., dopamine and melatonin ...
Kenkichi Baba, Jason P. DeBruyne, Gianluca Tosini   +2 more
doaj   +1 more source

Hepatic gene therapy rescues high-fat diet responses in circadian Clock mutant mice

Molecular Metabolism, 2017
Objective: Circadian Clock gene mutant mice show dampened 24-h feeding rhythms and an increased sensitivity to high-fat diet (HFD) feeding. Restricting HFD access to the dark phase counteracts its obesogenic effect in wild-type mice.
Judit Meyer-Kovac, Isa Kolbe, Lea Ehrhardt, Alexei Leliavski, Jana Husse, Gabriela Salinas, Thomas Lingner, Anthony H. Tsang, Johanna L. Barclay, Henrik Oster   +9 more
doaj   +1 more source

The Melanocortin-4 Receptor Integrates Circadian Light Cues and Metabolism [PDF]

, 2015
The melanocortin system directs diverse physiological functions from coat color to body weight homoeostasis. A commonality among melanocortin-mediated processes is that many animals modulate similar processes on a circannual basis in response to longer ...
Arble, Deanna M., Herman, James P., Holland, Jenna, Morano, Rachel, Ottaway, Nickki, Perez-Tilve, Diego, Pressler, Joshua W., Sandoval, Darleen A., Seeley, Randy J., Sorrell, Joyce, Woods, Stephen C.   +10 more
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Exploitation of Outgoing and Incoming Telephone Calls in the Context of Circadian Rhythms of Social Activity Among Elderly People: Observational Descriptive Study

JMIR mHealth and uHealth, 2020
BackgroundIn the elderly population, analysis of the circadian rhythms of social activity may help in supervising homebound disabled and chronically ill populations.
Aubourg, Timothée, Demongeot, Jacques, Provost, Hervé, Vuillerme, Nicolas   +3 more
doaj   +1 more source

Splice variants of DOMINO control Drosophila circadian behavior and pacemaker neuron maintenance. [PDF]

, 2019
Circadian clocks control daily rhythms in behavior and physiology. In Drosophila, the small ventral lateral neurons (sLNvs) expressing PIGMENT DISPERSING FACTOR (PDF) are the master pacemaker neurons generating locomotor rhythms.
Cai, Yao, Chiu, Joanna C, Lam, Vu H, Liu, Zhenxing, Mcintire, Pearson, Niu, Ye, Tabuloc, Christine A, Xue, Yongbo, Zhang, Yong   +8 more
core   +1 more source

Voluntary exercise can strengthen the circadian system in aged mice [PDF]

, 2013
Consistent daily rhythms are important to healthy aging according to studies linking disrupted circadian rhythms with negative health impacts. We studied the effects of age and exercise on baseline circadian rhythms and on the circadian system's ability ...
A Davidson, A Power, A Watanabe, AA Kondratova, AC King, AJ Davidson, AJ Davidson, B Rusak, C Castillo, CJ Guenthner, DE Kolker, DF Swaab, DJ Buysse, DJ Dijk, DJ Foley, DJ Foley, E Satinoff, E. Zimmerman, EK Baehr, F Aujard, G. S. Lall, GJ Tranah, GS Passos, H Albus, H Li, H. Queenan, HT vanderLeest, I. Song, IN Karatsoreos, J Schaap, K Cho, KJ Reid, M Asai, M Harrington, M Münch, M Nagano, M Palomba, M. E. Harrington, MA Grandner, MJ Duncan, MJ Duncan, MU Gillette, MW Greene, MW Marlatt, N Mrosovsky, O Castanon-Cervantes, P. C. Molyneux, PC Yannielli, RD Nebes, S Ancoli-Israel, S Benloucif, S Farajnia, S Kiessling, S Yamazaki, S Yamazaki, S Yamazaki, S. M. Biello, SH Yoo, SJ Aton, SM Biello, T Deboer, T Yoshikawa, T. L. Leise, TA Bedrosian, TA Martino, TA Martino, TJ Nakamura, TL Leise, U Abraham, U Albrecht, VS Valentinuzzi, W Nakamura, Y Tahara, Y Zhang, Y Zhang   +74 more
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Xenotransplantation of Human glioblastoma in Zebrafish larvae: in vivo imaging and proliferation assessment

Biology Open, 2019
Glioblastoma (GBM) is the most prevalent type of primary brain tumor. Treatment options include maximal surgical resection and drug-radiotherapy combination.
Luis A. Vargas-Patron, Nathalie Agudelo-Dueñas, Jorge Madrid-Wolff, Juan A. Venegas, John M. González, Manu Forero-Shelton, Veronica Akle   +6 more
doaj   +1 more source

Circadian clocks and breast cancer [PDF]

, 2016
Circadian clocks respond to environmental time cues to coordinate 24-hour oscillations in almost every tissue of the body. In the breast, circadian clocks regulate the rhythmic expression of numerous genes.
Blakeman, V, Meng, Q-J, Streuli, CH, Williams, JL   +3 more
core   +2 more sources