Results 71 to 80 of about 213,878 (305)

Understanding Biological Mechanisms: Using Illustrations from Circadian Rhythm Research [PDF]

, 2012
In many fields of biology, researchers explain a phenomenon by characterizing the responsible mechanism. This requires identifying the candidate mechanism, decomposing it into its parts and operations, recomposing it so as to understand how it is ...
Bechtel, William
core  

The circadian clock that controls gene expression in Arabidopsis is tissue specific [PDF]

, 2002
The expression of CHALCONE SYNTHASE (CHS) expression is an important control step in the biosynthesis of flavonoids, which are major photoprotectants in plants.
McGrath, Robert B, Andrew J. Millar, James R. Lynn, Thain, Simon C, Millar, Andrew J; id_orcid, Robert. B. McGrath, Lynn, James R, Murtas, Giovanni, Giovanni Murtas, Simon C. Thain   +9 more
core   +1 more source

Entorhinal Astrocyte Transplants Restore Spatial Exploration and Alleviate Amyloid‐Beta Pathology in Alzheimer's Mice

Advanced Science, EarlyView.
Impaired MEC astrocytic Ca2+ signaling is associated with fragmented spatial exploration in AD mice. Region‐specific glial progenitor transplantation generates engrafted astrocytes that are accompanied by improved AQP4 polarization, reduced amyloid‐β‐associated pathology, attenuated neuroinflammation, preserved synaptic integrity, and ameliorated ...
Fengjuan Wu, Jihua Fan, Xiang Zhou, Zhiqi Yang, Mingyue Gong, Mingzhu Huang, Zhenlu Cai, Shaofan Yang, Teng Teng, Chuanyan Yang, Jin Li, Haoyu Wang, Shuangshuang Dai, Chunhai Chen, Xiaowei Chen, Manxia Wang, Kuan Zhang   +16 more
wiley   +1 more source

Targeting β2‐Adrenergic Receptor Stability With Lycorine Reveals a Host‐Directed Pathway for Antiviral Defense Against Poxviruses

Advanced Science, EarlyView.
Chronic stress drives autophagy‐mediated β2‐AR degradation, impairing antiviral immunity and promoting poxvirus lethality. Lycorine directly stabilizes β2‐AR to restore host defense, suppress excessive inflammation and improve survival. ABSTRACT Psychological stress is a pervasive yet poorly understood modulator of infectious disease outcomes. Here, we
Xin Zhang, Shuqin Xu, Zixuan Zhang, Chenwen Wan, Xiaoqin Wang, Peihua Wang, Huini Yang, Tianxiao Huang, Yijia Yuan, Faiza Atique, Rui Yang, Yingli He, Zhijun Liu   +12 more
wiley   +1 more source

Associations between sleep and circadian rhythm disruption and perinatal anxiety

npj Biological Timing and Sleep
This review summarizes findings on the role of sleep and circadian rhythm disruption in perinatal anxiety. Sleep disruption is concurrently and prospectively associated with anxiety in pregnancy and postpartum. Findings on circadian rhythm disruption and
Rebecca C. Cox
doaj   +1 more source

Targeting the NR1D1–IGF2BP2–V‐ATPase Axis With Hybrid Nanovesicles Restores Macrophage Rhythms to Reverse Sepsis‐Induced Immunosuppression

Advanced Science, EarlyView.
Sepsis disrupts immune‐cell rhythms and weakens bacterial clearance. Biomimetic nanovesicles combining erythrocyte and inflammation‐activated macrophage membranes deliver siNR1D1 to dysfunctional macrophages, restoring the NR1D1–IGF2BP2–V‐ATPase pathway, circadian regulation, phagolysosomal acidification, and antimicrobial defense.
Lang Chen, Wenyi Lin, Lang Jiang, Xuehui Gao, Chenyan Yu, Jili Han, Zhenping Liu, Xuefeng Li, Mei He, Chang Li, Qilan Li, Chaoying Song, Jiqian Xu, You Shang   +13 more
wiley   +1 more source

Tracking Vigilance While Driving: Pilot Study of Heart Rate Variability Classification Under a Controlled Sleep-Deprivation Protocol

Sensors
Decreased vigilance associated with drowsiness is a major cause of motor vehicle crashes, but its physiological characterization and detection remain difficult due to behavioral and environmental confounding factors.
James Elber Duverger, Eli Moser, Philippe Boudreau, Marie Claude Ouimet, Diane B. Boivin, Alireza Saidi   +5 more
doaj   +1 more source

Quantitative analysis of regulatory flexibility under changing environmental conditions [PDF]

, 2010
The circadian clock controls 24-h rhythms in many biological processes, allowing appropriate timing of biological rhythms relative to dawn and dusk. Known clock circuits include multiple, interlocked feedback loops.
Andrew J Millar, Paul E Brown, David A Rand, Kirsten Knox, Knox, Kirsten, Thomson, Adrian W, Akman, Ozgur E, Lumsden, Peter J, Millar, A. J., Ozgur E Akman, Edwards, Kieron D, Brown, Paul E., Rand, D. A., Alexandra Pokhilko, Edwards, Kieron D., Thomson, Adrian W., Rand, David A, Lumsden, P. J., Nagy, Ferenc, Laszlo Kozma‐Bognar, Ra Pokhilko, Adrian W Thomson, Peter J Lumsden, Akman, Ozgur E., Kozma-Bognar, Laszlo, Kieron D Edwards, Ferenc Nagy, Pokhilko, Alexandra, Brown, Paul E, Millar, Andrew J; id_orcid, David A R, Laszlo Kozma-bognar   +31 more
core   +1 more source

Spatiotemporal Multi‐Omic Mapping Reveals Liver‐Muscle Metabolic Crosstalk in Cancer Cachexia

Advanced Science, EarlyView.
The interactive CCAtlas platform delineates cross‐species, spatiotemporal, and sex‐specific molecular dynamics and metabolic rewiring across organs during cancer cachexia. Hepatic Gamt downregulation curtails hepatic creatine synthesis to trigger systemic creatine insufficiency and consequent skeletal muscle atrophy in LLC tumour‐bearing mice ...
Zihan Tian, Qianyu Wang, Wenyan Gao, Xianfeng Li, Jiawen Fan, Xiaoliang Wu, Siqi Liu, Xiangdong Ming, Danna Yeerken, Mutian Shen, Qingjie Min, Qimin Zhan, Yan Wang   +12 more
wiley   +1 more source

Circadian‐Inspired Hydrogel Moisture Electricity Generation

Advanced Science, EarlyView.
A circadian‐inspired hydrogel moisture‐electric generator enables sustainable electricity generation by autonomously current direction switching between daytime and nighttime. This reversible output is accompanied by inversion of the internal water gradient, which effectively reduce hydrogel fatigue and offers a new strategy for harvesting diurnal ...
Ziqi Li, Dilalanmu Ahemaitijiang, Hongfei Yang, Xuan Zhao, Mengjiao Pan, Jun Wan, Pingan Zhu, Dahua Shou   +7 more
wiley   +1 more source