Results 71 to 80 of about 86,709 (313)

An Activity‐Dependent NEPAS–PTX3 Axis Links Neurovascular and Myelin Deficits to Cognitive Impairment

Advanced Science, EarlyView.
An activity‐dependent pathway links prefrontal circuit hypoactivity to cognitive impairment. Reduced PVA–mPFC activity upregulates NEPAS, which suppresses PTX3 secretion, leading to impaired angiogenesis, myelin deficits, and memory decline. Rescue is achieved by NEPAS knockdown or chemogenetic circuit activation.
Boya Hu, Zifei Chen, Bingmei Sun, Jiale Gao, Jiale Xu, Xiaochun Guo, Fenfei Gao, Zhongsi Wang, Jie Wu, Xiaoyu Ji, Peipei Liu, Bing Huang   +11 more
wiley   +1 more source

Associations between sleep and circadian rhythm disruption and perinatal anxiety

npj Biological Timing and Sleep
This review summarizes findings on the role of sleep and circadian rhythm disruption in perinatal anxiety. Sleep disruption is concurrently and prospectively associated with anxiety in pregnancy and postpartum. Findings on circadian rhythm disruption and
Rebecca C. Cox
doaj   +1 more source

Disruption of rhythms of molecular clocks in primary synovial fibroblasts of patients with osteoarthritis and rheumatoid arthritis, role of IL-1;2/TNF [PDF]

, 2012
Introduction: Circadian rhythms play an important role in the body and in single cells. Rhythms of molecular clocks have not been investigated in synovial fibroblasts (SF) of patients with osteoarthritis (OA) and rheumatoid arthritis (RA).
Haas, Stefanie, Stefanie Haas, Rainer H Straub, Straub, Rainer H.   +3 more
core   +1 more source

Synchronization‐Dissipation in the Cardiorespiratory System

Advanced Science, EarlyView.
By modeling central nervous coupling and viscoelastic interactions in the cardiorespiratory system we show that synchronization produces a 10% gain in cardiac efficiency in humans. It is surmised that respiratory sinus arrhythmia improves cardiac pumping efficiency by reducing dynamic stress and power dissipation in the pulmonary vasculature.
Joshua R. Border, Alain Nogaret, Andrew Lefevre, Vishal Jain   +3 more
wiley   +1 more source

Conditional circadian regulation of PHYTOCHROME A gene expression

, 2001
The phytochrome photoreceptors and the circadian clock control many of the same developmental processes, in all organs and throughout the growth of Arabidopsis plants. Phytochrome A (phyA) provides light input signals to entrain the circadian clock.
Nagy, F, Hall, Anthony, Kozma-Bognár, L, Tóth, R, Millar, A J; id_orcid   +4 more
core   +1 more source

Robustness from flexibility in the fungal circadian clock [PDF]

, 2010
Background Robustness is a central property of living systems, enabling function to be maintained against environmental perturbations. A key challenge is to identify the structures in biological circuits that confer system-level properties such as ...
Andrew J Millar, Paul E Brown, David A Rand, Akman, Ozgur E., Rand, D. A. (David A.), Akman, Ozgur E, Brown, Paul E, Rand, David A., Ozgur E Akman, Millar, Andrew J; id_orcid, Brown, Paul E., Millar, A. J. (Andrew J.), Millar, Andrew J., Rand, David A   +13 more
core   +1 more source

Fosl2 Regulates FSH‐Dependent Follicle Maturation Through Feedback Amplification of FSH/FSHR Signaling

Advanced Science, EarlyView.
This study identifies a FOSL2‐driven positive feedback loop that amplifies FSH/FSHR signaling. During FSH‐dependent follicle maturation, FSH induces Fosl2 expression via the cAMP‐PKA‐CREB cascade. FOSL2 in turn binds the promoters of Fshr and estrogen‐biosynthesis genes to enhance their transcription, thereby increasing Fshr mRNA level and amplifying ...
Hongru Shi, Chaoli Chen, Zaohong Ran, Jianning Liao, Zian Wu, Xiaodong Wang, Yongheng Zhao, Wenkai Ke, Bowen Tan, Yun Liu, Youqiang Su, Wei Ren, Xiang Li, Changjiu He   +13 more
wiley   +1 more source

Serotonin and corticosterone rhythms in mice exposed to cigarette smoke and in patients with COPD:implication for COPD-associated neuropathogenesis

, 2014
The circadian timing system controls daily rhythms of physiology and behavior, and disruption of clock function can trigger stressful life events. Daily exposure to cigarette smoke (CS) can lead to alteration in diverse biological and physiological ...
Hongwei Yao, Lyda, Elizabeth, Sime, Patricia J, Patricia J Sime, Michael T Sellix, Isaac K Sundar, Sundar Isaac K., Yao Hongwei, Yao, Hongwei, Sellix Michael T., Sime Patricia J., Rahman Irfan, Sundar, Isaac K, Huang, Yadi, Yadi Huang, Rahman, Irfan, Irfan Rahman, Lyda Elizabeth, Elizabeth Lyda, Huang Yadi, Sellix, Michael T   +20 more
core   +1 more source

ELF4 is required for oscillatory properties of the circadian clock [PDF]

, 2007
Circadian clocks are required to coordinate metabolism and physiology with daily changes in the environment. Such clocks have several distinctive features, including a free-running rhythm of approximately 24 h and the ability to entrain to both light or ...
Nagy, Ferenc, Davis, Seth J, Gyula, Péter, Amasino, R., Doyle, M. R., Davis, S., Millar, A., Hall, Anthony, Amasino, Richard M, Davis, S. J., McWatters, Harriet G, Doyle, M., Doyle, Mark R, Kolmos, E., Amasino, R. M., Millar, A. J., Gyula, P., McWatters, H. G., Millar, Andrew J; id_orcid, Hall, A., Nagy, F., McWatters, H., Kolmos, Elsebeth   +22 more
core   +1 more source

Falls risk, circadian rhythms and melatonin : current perspectives [PDF]

, 2020
: Aging is associated with weakening of the circadian system. The circadian amplitude of most physiological variables is reduced, while the circadian phase becomes more labile and tends to occur earlier with advancing age.
Goswami, Nandu, Abulafia, Carolina Andrea, Cardinali, Daniel, Moser, Maximilian, Vigo, Daniel Eduardo, Cornelissen, Germaine, Cardinali, Daniel Pedro, Abulafia, Carolina, Vigo, Daniel   +8 more
core   +1 more source