Results 71 to 80 of about 206,395 (302)

SPSB1 Promotes Subcutaneous Adipose Hyperplasia in Facial Port‐Wine Stains by Controlling HDAC1 Degradation and Stability Through Two Distinct Proteolytic Pathways

Advanced Science, EarlyView.
In PWS‐ASPCs, FOSL1 drives the expression of SPSB1. SPSB1, as part of the ESC complex, further binds to HDAC1 and promotes K29‐linked and K48‐linked polyubiquitination of HDAC1. These modifications facilitate the degradation of HDAC1 through the ALP and UPS pathways, respectively.
Hongrui Chen, Bin Sun, Yajing Qiu, Chen Hua, Xiaoxi Lin, Wei Gao   +5 more
wiley   +1 more source

The contributions of interlocking loops and extensive nonlinearity to the properties of circadian clock models [PDF]

, 2010
Sensitivity and robustness are essential properties of circadian clock systems, enabling them to respond to the environment but resist noisy variations. These properties should be recapitulated in computational models of the circadian clock.
Andrew J Millar, Painter, Kevin J., Saithong Treenut, Saithong T., Painter K. J., Painter Kevin J., Saithong, Treenut, Kevin J Painter, Millar Andrew J., Andrew J. Millar, Millar A. J., Millar, Andrew J; id_orcid, Treenut Saithong, Painter, Kevin J, Millar, Andrew J., Kevin J. Painter   +15 more
core   +1 more source

Machine Learning‐Driven Design of Multicomponent Bone Inorganic Matrix Mimicking Scaffolds for Osteogenesis Enhanced by Neurogenesis

Advanced Science, EarlyView.
Schematic illustration of development of experimental datasets and algorithm models, screening and preparation of the scaffolds and their applications in vivo. ABSTRACT Bone defects require materials with osteogenic, neurogenic, and angiogenic activity, yet designing such materials within high‐dimensional compositional spaces remains challenging. Here,
Kunlu Lin, Ying Yang, Chuyao Zhou, Hanyue Mao, Zhiquan Zhang, Libangxi Liu, Xiaoying Yu, Haoming Liu, Long Liu, Xiaoyan Wang   +9 more
wiley   +1 more source

Non-alcoholic Fatty pancreas disease pathogenesis: a role for developmental programming and altered circadian rhythms. [PDF]

, 2014
Emerging evidence suggests that maternal obesity (MO) predisposes offspring to obesity and the recently described non-alcoholic fatty pancreas disease (NAFPD) but involved mechanisms remain unclear.
Mouralidarane Angelina, Chiara Saracino, Lucilla Poston (200809), Francesca Rappa, Ruma Saraswati, Fusai, Giuseppe, Paul D. Taylor (200813), Pazienza Valerio, Junpei Soeda, Carter, Rebeca, Jude A Oben, Angelina Mouralidarane (540950), Saraswati Ruma, Paul D Taylor, Mouralidarane, Angelina, Oben, JA, Saraswati, R, Fusai Giuseppe, Marco Novelli, Carter, R, Poston Lucilla, Marco Novelli (540954), Giuseppe Fusai (540955), Shuvra Ray (540951), Soeda, Junpei, Soeda, J, Pombo, J, Mouralidarane, A, Rappa, F, Ruma Saraswati (540953), Pazienza, Valerio, Novelli, Marco, Taylor Paul D., Joaquim Pombo (540952), Carter Rebeca, Saracino, C, Manlio Vinciguerra (287299), Saraswati, Ruma, Novelli, M, Oben, Jude A, Angelina Mouralidarane, Pombo, Joaquim, Fusai, G, RAPPA, Francesca, Saracino, Chiara, Novelli Marco, Rappa Francesca, Lucilla Poston, Francesca Rappa (55683), Manlio Vinciguerra, Rebeca Carter, Saracino Chiara, Poston, Lucilla; id_orcid, Pazienza, V, Vinciguerra, M, Joaquim Pombo, Rebeca Carter (540949), Ray Shuvra, Vinciguerra, Manlio, Vinciguerra, M. Oben J.A., Junpei Soeda (453348), Valerio Pazienza, Poston, L, Vinciguerra Manlio, Ray, S, Jude A. Oben (453352), Taylor, PD, Soeda Junpei, Giuseppe Fusai, Oben Jude A., Pombo Joaquim, Valerio Pazienza (174196), Taylor, Paul D; id_orcid, Chiara Saracino (540956), Ray, Shuvra, Shuvra Ray   +75 more
core   +1 more source

Entorhinal Astrocyte Transplants Restore Spatial Exploration and Alleviate Amyloid‐Beta Pathology in Alzheimer's Mice

Advanced Science, EarlyView.
Impaired MEC astrocytic Ca2+ signaling is associated with fragmented spatial exploration in AD mice. Region‐specific glial progenitor transplantation generates engrafted astrocytes that are accompanied by improved AQP4 polarization, reduced amyloid‐β‐associated pathology, attenuated neuroinflammation, preserved synaptic integrity, and ameliorated ...
Fengjuan Wu, Jihua Fan, Xiang Zhou, Zhiqi Yang, Mingyue Gong, Mingzhu Huang, Zhenlu Cai, Shaofan Yang, Teng Teng, Chuanyan Yang, Jin Li, Haoyu Wang, Shuangshuang Dai, Chunhai Chen, Xiaowei Chen, Manxia Wang, Kuan Zhang   +16 more
wiley   +1 more source

Associations between sleep and circadian rhythm disruption and perinatal anxiety

npj Biological Timing and Sleep
This review summarizes findings on the role of sleep and circadian rhythm disruption in perinatal anxiety. Sleep disruption is concurrently and prospectively associated with anxiety in pregnancy and postpartum. Findings on circadian rhythm disruption and
Rebecca C. Cox
doaj   +1 more source

Serotonin and circadian rhythms. [PDF]

Psychology & Neuroscience, 2010
All mammal behaviors and functions exhibit synchronization with environmental rhythms. This is accomplished through an internal mechanism that generates and modulates biological rhythms. The circadian timing system, responsible for this process, is formed by connected neural structures.
Pontes, André Luiz Bezerra de, Engelberth, Rovena Clara Galvão Januário, Nascimento Júnior, Expedito da Silva, Cavalcante, Judney Cley, Costa, Miriam Stela Maris de Oliveira, Pinato, Luciana, Toledo, Claudio Antonio Barbosa de, Cavalcante, Jeferson de Souza   +7 more
openaire   +5 more sources

Effect of deuterium on the circadian period and metabolism in wild-type and tau mutant Syrian hamsters [PDF]

, 2000
Homozygous tau mutant Syrian hamsters (tau-/-) have a free-running circadian period (τ) around 20 h and a proportionally higher metabolic rate compared with wild-type hamsters (tau+/+) with a period of circa 24 h.
Malgorzata Oklejewicz, Daan, S, Hut, Roelof A.,, Hut, RA, Roelof A Hut, Serge Daan, Daan, Serge,, Oklejewicz, M, Oklejewicz, Malgorzata,   +8 more
core   +1 more source

Human Circadian Phase Estimation from Signals Collected in Ambulatory Conditions Using an Autoregressive Model [PDF]

, 2013
Phase estimation of the human circadian rhythm is a topic that has been explored using various modeling approaches. The current models range from physiological to mathematical, all attempting to estimate the circadian phase from different physiological ...
Gil, Enrique A, Møst, Els I S, Beersma, Domien G M, Beersma, Domien G. M., Møst, Els I.S., Aubert, Xavier L, Gil, Enrique A.,, Aubert, Xavier L.,, Aubert, Xavier L., Beersma, Domien G.M.,, Most, Els I. S., Gil, Enrique A., Møst, Els I.S.,   +12 more
core   +1 more source

Targeting β2‐Adrenergic Receptor Stability With Lycorine Reveals a Host‐Directed Pathway for Antiviral Defense Against Poxviruses

Advanced Science, EarlyView.
Chronic stress drives autophagy‐mediated β2‐AR degradation, impairing antiviral immunity and promoting poxvirus lethality. Lycorine directly stabilizes β2‐AR to restore host defense, suppress excessive inflammation and improve survival. ABSTRACT Psychological stress is a pervasive yet poorly understood modulator of infectious disease outcomes. Here, we
Xin Zhang, Shuqin Xu, Zixuan Zhang, Chenwen Wan, Xiaoqin Wang, Peihua Wang, Huini Yang, Tianxiao Huang, Yijia Yuan, Faiza Atique, Rui Yang, Yingli He, Zhijun Liu   +12 more
wiley   +1 more source