Results 101 to 110 of about 206,395 (302)

Isolation of new genes involved in temperature synchronization of the circadian clock of Drosophila melanogaster [PDF]

, 2010
PhDCircadian clocks regulate behaviour and physiology of many organisms and keep them in synchrony with the environment. Drosophila's circadian clock is mainly synchronized by natural light-dark cycles and temperature fluctuations, both at molecular
Simoni, Alekos
core   +3 more sources

Glial Cells in the Genesis and Regulation of Circadian Rhythms

Frontiers in Physiology, 2018
Circadian rhythms are biological oscillations with a period of ~24 h. These rhythms are orchestrated by a circadian timekeeper in the suprachiasmatic nucleus of the hypothalamus, the circadian “master clock,” which exactly adjusts clock outputs to solar ...
Donají Chi-Castañeda, Donají Chi-Castañeda, Arturo Ortega   +2 more
doaj   +1 more source

A Mouse Model of Depression‐Tumor Multimorbidity Reveals the Mechanism of Tumor Growth Accelerated by Depression

Animal Research and One Health, EarlyView.
Depression accelerates tumor growth by dysregulation of tumor immune microenvironment. (A) Modeling methods: Subcutaneous tumor models were established under chronic unpredictable mild stress conditions, including cold swimming, physical restraint, and food/water deprivation, leading to increased tumor growth.
Yakun Ren, Xinpei Wang, Wen Wang, Xingjiu Yang, Mengyuan Li, Jing Du, Ran Gao   +6 more
wiley   +1 more source

Clock Genes Regulate Ca2+ Signaling and Mitochondrial Bioenergetics to Inhibit Sjögren Disease

Arthritis &Rheumatology, EarlyView.
Objective Although Ca2+ signaling and metabolism have been identified as key determinants for the development of Sjögren disease (SjD), the intricate connection between them and salivary gland physiology remains poorly understood. Methods Fluorescence‐based Ca2+ imaging, RNA sequencing, and mitochondrial activity were used to investigate the effects of
Viktor R. Drel, Manigandan Venkatesan, Rahul S. Jasrotia, Yuyang Sun, Viviane Nascimento da Conceicao, Neelanjan Vishnu, Shankara N. Varadarajan, Venugopal R. Bovilla, Rajender K. Motiani, Shobhan Gaddameedhi, Bibhuti B. Mishra, Muniswamy Madesh, Brij B. Singh   +12 more
wiley   +1 more source

Chronotherapy and intervertebral disc degeneration: understanding the role of circadian rhythm in degenerative processes

Frontiers in Cell and Developmental Biology
Intervertebral disc degeneration (IDD) and low back pain are prevalent issues globally, affecting a significant portion of the adult population. Recent research has highlighted the crucial role of circadian rhythms in the degenerative processes of ...
Cong Zhang, Cong Zhang, Cong Zhang, Rende Zhang, Guanghai Zhao, Guanghai Zhao, Guanghai Zhao, Zuolong Wu, Zuolong Wu, Zuolong Wu, Wei Song, Wei Song, Wei Song, Rui Ran, Rui Ran, Rui Ran, Kaisheng Zhou, Kaisheng Zhou, Kaisheng Zhou, Haihong Zhang, Haihong Zhang, Haihong Zhang   +21 more
doaj   +1 more source

ELF4 is required for oscillatory properties of the circadian clock [PDF]

, 2007
Circadian clocks are required to coordinate metabolism and physiology with daily changes in the environment. Such clocks have several distinctive features, including a free-running rhythm of approximately 24 h and the ability to entrain to both light or ...
Nagy, Ferenc, Davis, Seth J, Gyula, Péter, Amasino, R., Doyle, M. R., Davis, S., Millar, A., Hall, Anthony, Amasino, Richard M, Davis, S. J., McWatters, Harriet G, Doyle, M., Doyle, Mark R, Kolmos, E., Amasino, R. M., Millar, A. J., Gyula, P., McWatters, H. G., Millar, Andrew J; id_orcid, Hall, A., Nagy, F., McWatters, H., Kolmos, Elsebeth   +22 more
core   +1 more source

Dual Effects of β‐TrCP2 Deletion in Bone Homeostasis: Suppression of Osteoclastogenesis and Enhancement of Osteoblast Activity

Arthritis &Rheumatology, Accepted Article.
Objectives To elucidate role of beta‐transducin repeat‐containing protein 2 (β‐TrCP2) in bone homeostasis for its potential as a therapeutic target for osteoporosis. Methods The role of β‐TrCP2 in bone phenotypes was investigated using systemic β‐TrCP1KO and β‐TrCP2KO mice, along with myeloid‐specific conditional β‐TrCP2KO (β‐TrCP2ΔM) mice.
Woo Jung Kim, Sora Han, Hye In Ka, Sun Young Lee, Jiwon Kim, Hyunjeong Joo, Sujung Soh, Gaeun Oh, Kyung Hyun Yoo, Seung Hyun Han, Yeongkag Kwon, Choogon Lee, Kyung‐Hyun Park‐Min, Se Hwan Mun, Young Yang   +14 more
wiley   +1 more source

Epigenetic Mechanisms in the Transcriptional Regulation of Circadian Rhythm in Mammals

Biology
Almost all organisms, from the simplest bacteria to advanced mammals, havea near 24 h circadian rhythm. Circadian rhythms are highly conserved across different life forms and are regulated by circadian genes as well as by related transcription factors ...
Wei Mao, Xingnan Ge, Qianping Chen, Jia-Da Li   +3 more
doaj   +1 more source

Rhythmic potassium transport regulates the circadian clock in human red blood cells

Nature Communications, 2017
Circadian rhythms usually rely on cyclic variations in gene expression. Red blood cells, however, display circadian rhythms while being devoid of nuclear DNA.
Erin A. Henslee, Priya Crosby, Stephen J. Kitcatt, Jack S. W. Parry, Andrea Bernardini, Rula G. Abdallat, Gabriella Braun, Henry O. Fatoyinbo, Esther J. Harrison, Rachel S. Edgar, Kai F. Hoettges, Akhilesh B. Reddy, Rita I. Jabr, Malcolm von Schantz, John S. O’Neill, Fatima H. Labeed   +15 more
doaj   +1 more source

Circadian Regulation of Synaptic Plasticity

Biology, 2016
Circadian rhythms refer to oscillations in biological processes with a period of approximately 24 h. In addition to the sleep/wake cycle, there are circadian rhythms in metabolism, body temperature, hormone output, organ function and gene expression ...
Marcos G. Frank
doaj   +1 more source