Results 101 to 110 of about 86,709 (313)

Quantitative analysis of regulatory flexibility under changing environmental conditions [PDF]

, 2010
The circadian clock controls 24-h rhythms in many biological processes, allowing appropriate timing of biological rhythms relative to dawn and dusk. Known clock circuits include multiple, interlocked feedback loops.
Andrew J Millar, Paul E Brown, David A Rand, Kirsten Knox, Knox, Kirsten, Thomson, Adrian W, Akman, Ozgur E, Lumsden, Peter J, Millar, A. J., Ozgur E Akman, Edwards, Kieron D, Brown, Paul E., Rand, D. A., Alexandra Pokhilko, Edwards, Kieron D., Thomson, Adrian W., Rand, David A, Lumsden, P. J., Nagy, Ferenc, Laszlo Kozma‐Bognar, Ra Pokhilko, Adrian W Thomson, Peter J Lumsden, Akman, Ozgur E., Kozma-Bognar, Laszlo, Kieron D Edwards, Ferenc Nagy, Lumsden, Peter J., Pokhilko, Alexandra, Brown, Paul E, Rand, David A., Millar, Andrew J; id_orcid, David A R, Millar, Andrew J., Laszlo Kozma-bognar   +34 more
core   +1 more source

Distinct Neuropsychiatric Profiles Associated With 17p11.2 Deletions and RAI1 Variants in Smith–Magenis Syndrome

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Smith–Magenis syndrome (SMS) results from either a recurrent 17p11.2 deletion or pathogenic variants in the retinoic acid induced 1 gene (RAI1). While neurodevelopmental impairment and behavioral dysregulation are well recognized, systematic genotype‐stratified analyses across psychiatric domains remain limited.
Albin Blanc, Christophe Nemos, Céline Bonnet, Mathilde Renaud, Sandra Chapuis, Pauline Boiroux, Marie‐Noëlle Babinet, Caroline Demily   +7 more
wiley   +1 more source

Chronotherapy and intervertebral disc degeneration: understanding the role of circadian rhythm in degenerative processes

Frontiers in Cell and Developmental Biology
Intervertebral disc degeneration (IDD) and low back pain are prevalent issues globally, affecting a significant portion of the adult population. Recent research has highlighted the crucial role of circadian rhythms in the degenerative processes of ...
Cong Zhang, Cong Zhang, Cong Zhang, Rende Zhang, Guanghai Zhao, Guanghai Zhao, Guanghai Zhao, Zuolong Wu, Zuolong Wu, Zuolong Wu, Wei Song, Wei Song, Wei Song, Rui Ran, Rui Ran, Rui Ran, Kaisheng Zhou, Kaisheng Zhou, Kaisheng Zhou, Haihong Zhang, Haihong Zhang, Haihong Zhang   +21 more
doaj   +1 more source

A Circadian Clock-Regulated Toggle Switch Explains AtGRP7 and AtGRP8 Oscillations in Arabidopsis thaliana

, 2013
Schmal C, Reimann P, Staiger D. A Circadian Clock-Regulated Toggle Switch Explains AtGRP7 and AtGRP8 Oscillations in Arabidopsis thaliana. PLoS Computational Biology. 2013;9(3): e1002986.The circadian clock controls many physiological processes in higher
Staiger Dorothee, Peter Reimann, Reimann, Peter, Schmal, Christoph, Dorothee Staiger (40787), Christoph Schmal, Schmal Christoph, Reimann Peter, Peter Reimann (395937), Staiger, Dorothee, Dorothee Staiger, Christoph Schmal (395936)   +11 more
core   +1 more source

Auditory Stimulation of Slow‐Wave Sleep Promotes Recovery after Brain Injury in an Animal Model

Annals of Neurology, EarlyView.
Objective Traumatic brain injury (TBI) significantly reduces the quality of life for millions of survivors worldwide, causing persistent brain tissue damage and cognitive impairments, with no established therapeutic interventions currently available.
Carlos G. Moreira, Adrian Müllner, Meltem Gönel, Pascal Hofmann, Filipe Teixeira, Rosa C. Paolicelli, Inês Dias, Sergio I. Nemirovsky, Christian R. Baumann, Daniela Noain   +9 more
wiley   +1 more source

Rhythmic potassium transport regulates the circadian clock in human red blood cells

Nature Communications, 2017
Circadian rhythms usually rely on cyclic variations in gene expression. Red blood cells, however, display circadian rhythms while being devoid of nuclear DNA.
Erin A. Henslee, Priya Crosby, Stephen J. Kitcatt, Jack S. W. Parry, Andrea Bernardini, Rula G. Abdallat, Gabriella Braun, Henry O. Fatoyinbo, Esther J. Harrison, Rachel S. Edgar, Kai F. Hoettges, Akhilesh B. Reddy, Rita I. Jabr, Malcolm von Schantz, John S. O’Neill, Fatima H. Labeed   +15 more
doaj   +1 more source

Novel mechanisms operating in the central pacemaker and in the light-synchronization pathway of Drosophila’s circadian clock

, 2011
PhDMost organisms display circadian rhythms of approximately 24 hours in many aspects of their physiology and behaviour. The synchronization between their internal rhythm and the environmental light-dark cycles is essential for an organism’s survival ...
Chen, Ko-Fan
core  

Dual‐Channel Interdigitated Aptamer‐Based Sensors for Rapid Small‐Molecule Detection in Biofluids

Angewandte Chemie International Edition, EarlyView.
An electrochemical aptamer sensing chip employs dual interdigitated electrodes and selective self‐assembled monolayer removal to convert small‐molecule recognition into robust “signal‐off/on” responses. This dual‐channel signal conversion minimizes background noise and accelerates probe diffusion, enabling rapid (as fast as 5–30 min), low‐volume ...
Senyao Wang, Ali Elmorsy, Defne Tüzün, Lilly Schmidt, Sebastian Freko, Lukas Hiendlmeier, Chen Wang, Alonso Ingar Romero, George Al Boustani, Hu Peng, Berna Özkale, Nako Nakatsuka, Bernhard Wolfrum   +12 more
wiley   +1 more source

Epigenetic Mechanisms in the Transcriptional Regulation of Circadian Rhythm in Mammals

Biology
Almost all organisms, from the simplest bacteria to advanced mammals, havea near 24 h circadian rhythm. Circadian rhythms are highly conserved across different life forms and are regulated by circadian genes as well as by related transcription factors ...
Wei Mao, Xingnan Ge, Qianping Chen, Jia-Da Li   +3 more
doaj   +1 more source

Circadian Regulation of Synaptic Plasticity

Biology, 2016
Circadian rhythms refer to oscillations in biological processes with a period of approximately 24 h. In addition to the sleep/wake cycle, there are circadian rhythms in metabolism, body temperature, hormone output, organ function and gene expression ...
Marcos G. Frank
doaj   +1 more source