Results 121 to 130 of about 206,395 (302)

Unveiling the novel role of circadian rhythms in sepsis and septic shock: unexplored implications for chronotherapy

Frontiers in Endocrinology
Circadian rhythms are critical to coordinating body processes to external environmental cues, such as light and feeding, to ensure efficiency and maintain optimal health. These rhythms are controlled by ‘clock’ transcription factors, such as Clock, Bmal1,
Stewart D. Ramsay, Stewart D. Ramsay, Stewart D. Ramsay, Marni A. Nenke, Marni A. Nenke, Emily J. Meyer, Emily J. Meyer, David J. Torpy, David J. Torpy, Richard L. Young, Richard L. Young, Richard L. Young, Richard L. Young   +12 more
doaj   +1 more source

Artificial intelligence for adaptive neuromodulation in drug‐resistant epilepsy

Epilepsia, EarlyView.
Abstract Drug‐resistant epilepsy (DRE) affects nearly one third of people with epilepsy and is associated with substantial cognitive, psychiatric, and mortality burdens. For patients who are not candidates for resection or laser interstitial thermal therapy, neuromodulation therapies such as vagus nerve stimulation, deep brain stimulation, and ...
Amir Hossein Daraie, Arianna Damiani, Mahsa Khoshkhou, Luis A. Sanchez, Rachel J. Smith, Shruti H. Agashe, Jorge A. Gonzalez‐Martinez, Jennifer Hopp, Adam S. Charles, Sridevi V. Sarma, Joon‐Yi Kang   +10 more
wiley   +1 more source

Dysfunctional circadian-driven dynamics in gut microbiota and tumor microenvironment

Gut Microbes
Circadian rhythms govern physiological activities through the precise modulation of gene expression and biochemical functions. Dysfunction of circadian rhythms is associated with an increased risk of tumor formation, growth, and metastasis, as well as ...
Taoxing Peng, Yiqi Wan, Yuxuan Sun, Yuexiang Ren, Fuli Shi, Yangfeng Lv, Xiangqiong Wen, Qiongfeng Chen, Xianhe Yang, Shan Xu, Jianming Li   +10 more
doaj   +1 more source

Seizure forecasting: The long and winding road to clinical translation

Epilepsia, EarlyView.
Abstract Seizure forecasting has progressed from theoretical aspiration to a rapidly advancing research domain, yet clinical translation remains limited. Over the past decades, advances in algorithm development, chronic electroencephalography (EEG), wearable sensors, and the characterization of seizure cycles have demonstrated that seizure risk is not ...
Philippa J. Karoly, Rachel E. Stirling, Mark J. Cook, Daniel M. Goldenholz, Maxime O. Baud, Vikram R. Rao, Solveig Vieluf, Benjamin H. Brinkmann   +7 more
wiley   +1 more source

Monthly or menstrual? A scoping review of catamenial epilepsy and non‐menstrual seizure rhythms

Epilepsia, EarlyView.
Abstract Objective Despite the reported high prevalence of catamenial epilepsy (CE), the condition remains poorly defined, with lack of consensus on what entails a menstrual‐related seizure exacerbation. Emerging evidence of multiday cycles of seizure activity, including about‐monthly cycles, present in both men and women, further confound the ...
Victoria Wong, Ewan S. Nurse, Ashley Reynolds, Mark J. Cook, Philippa J. Karoly   +4 more
wiley   +1 more source

Molecular insights of Circadian Rhythm in Chilopoda [PDF]

Journal of Stress Physiology & Biochemistry
The control of the sleep-wake cycle as well as several physiological and behavioral processes in living things depends on circadian rhythms. Circadian rhythms are regulated by internal biological clocks that coordinate with environmental stimuli like ...
Malathi R., Janice Marianne John
doaj  

Temperature homeostasis disruption and hypothalamic alterations in experimental drug‐resistant epilepsy

Epilepsia, EarlyView.
Abstract Objective Elevated body temperature may increase seizure risk, yet the relationship between thermoregulation and seizures, as well as the underlying mechanisms, remains poorly understood. We investigated whether thermoregulatory control is altered in experimental temporal lobe epilepsy (TLE), as such impairment could reduce the ability of ...
Rossella Di Sapia, Akash Bera, Omar Mamad, James D. Mills, Benjamin Villasana‐Salazar, Giada Lavigna, Edoardo Micotti, Manuela Conticello, Asmin Alam, Roberto Chiesa, Francesca Pagani, Roberta Frapolli, Angelo M. Lavecchia, Christodoulos Xinaris, Eleonora Aronica, Andre Altmann, Teresa Ravizza, Sanjay M. Sisodiya, David C. Henshall, Annamaria Vezzani   +19 more
wiley   +1 more source

Artificial intelligence in preclinical epilepsy research: Current state, potential, and challenges

Epilepsia Open, EarlyView.
Abstract Preclinical translational epilepsy research uses animal models to better understand the mechanisms underlying epilepsy and its comorbidities, as well as to analyze and develop potential treatments that may mitigate this neurological disorder and its associated conditions. Artificial intelligence (AI) has emerged as a transformative tool across
Jesús Servando Medel‐Matus, Cesar Santana‐Gomez, Ruby G. Escalante, Dominique Duncan, Pedro F. Viana, Giulia Sofia Cereda, Naoto Kuroda, Aristea S. Galanopoulou   +7 more
wiley   +1 more source

Prenatal betamethasone–postnatal N‐methyl‐D‐aspartic acid model of spasms: Update on mechanisms and treatments

Epilepsia Open, EarlyView.
Abstract Infantile epilepsy spasms syndrome (IESS), formerly known as infantile spasms or West Syndrome, is a severe epilepsy syndrome affecting about 3 in 10,000 newborns in the United States. Characterized by clusters of epileptic spasms, interictal hypsarrhythmia, and developmental delays, IESS has diverse causes, including structural‐metabolic ...
Kayla Vieira, Antonia Schonwald, Chian‐Ru Chern, Kamya Shah, Jana Velíšková, Libor Velíšek   +5 more
wiley   +1 more source

Thinking Dynamically About Biological Mechanisms: Networks of Coupled Oscillators [PDF]

, 2012
Explaining the complex dynamics exhibited in many biological mechanisms requires extending the recent philosophical treatment of mechanisms that emphasizes sequences of operations.
Bechtel, William, Abrahamsen, Adele
core