Mechanism for 12 Hr Rhythm Generation by the Circadian Clock
Cell Reports, 2013 In addition to the well-known circadian rhythms in animal behavior, cell biology, and gene expression, there are also 12 hr rhythms. The mechanism giving rise to these 12 hr rhythms is not clear.
Pål O. Westermark, Hanspeter Herzel
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New perspectives on the role of melatonin in human sleep, circadian rhythms and their regulation
British Journal of Pharmacology, 2018 In mammals, a central circadian clock, located in the suprachiasmatic nuclei (SCN) of the hypothalamus, tunes the innate circadian physiological rhythms to the ambient 24 h light–dark cycle to invigorate and optimize the internal temporal order.
N. Zisapel
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Integration of circadian and hypoxia signaling via non‐canonical heterodimerization
FEBS Letters, EarlyView.CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
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Pathophysiological Models of Hypersomnolence Associated With Depression
Biological Psychiatry Global Open ScienceUp to 25% of patients with depression experience hypersomnolence (e.g., excessive daytime sleepiness, hypersomnia, and/or sleep inertia), which is associated with treatment resistance, overall poorer outcomes, and safety concerns while driving ...
Christophe Moderie, Diane B. Boivin
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Circadian Rhythms and Melatonin Metabolism in Patients With Disorders of Gut-Brain Interactions [PDF]
, 2022 Sophie Fowler +4 more
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Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
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Ciradian dysrhythmias in the EEG of children with clonazepam treatment [PDF]
, 1984 The effects of different anticonvulsants on the system of cir-cadian and ultradian rhythms in the EEG of children was investigated in ten 24*-h recordings of children with different forms of epilepsy.
Arbogast, B. +4 more
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Circadian rhythms: a regulator of gastrointestinal health and dysfunction
Expert Review of Gastroenterology & Hepatology, 2019 Introduction: Circadian rhythms regulate much of gastrointestinal physiology including cell proliferation, motility, digestion, absorption, and electrolyte balance.
R. Voigt, C. Forsyth, A. Keshavarzian
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Day/night variations of myeloid and lymphoid cell subsets in the murine inguinal lymph node
FEBS Open Bio, EarlyView.The circadian system is involved in the temporal regulation of the immune system. Our study reveals that two innate immune populations, NKT cells and neutrophils, predominate at the beginning of the day in healthy mice, highlighting how the time of day influences immune responses.
Paula M. Wagner +6 more
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Potential Role for the Gut Microbiota in Modulating Host Circadian Rhythms and Metabolic Health
Microorganisms, 2019 This article reviews the current evidence associating gut microbiota with factors that impact host circadian-metabolic axis, such as light/dark cycles, sleep/wake cycles, diet, and eating patterns.
S. Parkar, A. Kalsbeek, J. Cheeseman
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