Results 241 to 250 of about 34,260 (269)

CircRNA-mediated ceRNA mechanism in Osteoarthritis: Special emphasis on circRNAs in exosomes and the crosstalk of circRNAs and RNA methylation

Biochemical Pharmacology, 2023
Osteoarthritis (OA) is an age-related joint disease with chronic inflammation, progressive articular cartilage destruction and subchondral bone sclerosis. CircRNAs (circRNAs) are a class of non-coding RNA with a circular structure that participate in a series of important pathophysiological processes of OA, especially its ceRNA mechanisms, and play an ...
Qiuyun, Xue, Yurong, Huang, Jun, Chang, Chenglong, Cheng, Yuting, Wang, Xiaomei, Wang, Chenggui, Miao   +6 more
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Circular RNAs (circRNAs) in cancer

Cancer Letters, 2018
Circular RNAs (circRNAs) are a class of non-coding RNAs that do not have 5' end caps or 3' end poly (A) tails. There are more than one hundred thousand genes that encode circRNAs. Clinical data show that there are differences in the expression of circRNAs in a variety of diseases, including cancer, suggesting that circRNA has a regulatory effect on ...
Ruoyu Zhou, Yuwei Wu, Wenxi Wang, Wenjia Su, Yicong Liu, Yumin Wang, Chunmei Fan, Xiaoling Li, Guiyuan Li, Yong Li, Wei Xiong, Zhaoyang Zeng   +11 more
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Structure-Mediated Degradation of CircRNAs

Trends in Cell Biology, 2020
The elaborate control of biogenesis and turnover is essential for circular RNAs (circRNAs) to exert their functions properly in eukaryotic cells, whereas how circRNAs are degraded remains unclear. A recent study by Fischer et al. reveals a novel structure-mediated circRNA decay that selectively degrades highly structured RNAs by UPF1 and G3BP1.
Yingli, Guo, Xiawei, Wei, Yong, Peng
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Nonradioactive Northern Blot of circRNAs

2018
Circular RNAs (circRNAs) are recognized as a special species of transcripts in metazoans with increasing studies, and northern blotting is a direct way to confirm the existence and to evaluate the size of individual circRNAs. Northern blotting probes can be radioactive isotope (32P) labeled, which is not environment-friendly and sometimes inconvenient ...
Xiaolin, Wang, Ge, Shan
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CircRNA regulates lung cancer metastasis

Gene
Lung cancer stands prominently among the foremost contributors to human mortality, distinguished by its elevated fatality rate and the second-highest incidence rate among malignancies. The metastatic dissemination of lung cancer stands as a primary determinant of its elevated mortality and recurrence rates, underscoring the imperative for comprehensive
Han, Li, Fan, Wu, Yaqi, Han, Ziyi, Guo, Tangbing, Chen, Zhongliang, Ma   +5 more
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CircRNAs in cancer therapy tolerance

Clinica Chimica Acta
The rapidly expanding field of circular RNA (circ-RNA) research has opened new avenues in cancer diagnostics and treatment, highlighting the role of serum circRNAs as potential biomarkers for assessing tumor therapy resistance. This review comprehensively compiles existing knowledge regarding the biogenesis, function, and clinical relevance of circRNAs,
Miao He, Yunyan Pan, Chongge You, Hongwei Gao   +3 more
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Exosome‐Based Mitochondrial Delivery of circRNA mSCAR Alleviates Sepsis by Orchestrating Macrophage Activation

Advanced Science, 2023
Mengying Wei, Xuekang Yang
exaly  

Targeting Mitochondria-Located circRNA SCAR Alleviates NASH via Reducing mROS Output

Cell, 2020
Qiyi Zhao, Jian-You Liao, Zhiyong Guo
exaly  

CircRNA-SORE mediates sorafenib resistance in hepatocellular carcinoma by stabilizing YBX1

Signal Transduction and Targeted Therapy, 2020
Junjie Xu, Wei Zheng, Kirill Gorshkov
exaly  

CircRNA knockdown based on antisense strategies

Drug Discovery Today
Circular RNAs (circRNAs) are a type of noncoding RNA that are formed by back-splicing from eukaryotic protein-coding genes. The most frequently reported and well-characterized function of circRNAs is their ability to act as molecular decoys, most often as miRNA and protein sponges.
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