Results 271 to 280 of about 45,661 (289)

Challenges and opportunities for circRNA identification and delivery

Critical reviews in biochemistry and molecular biology, 2023
Circular RNAs (circRNAs) are evolutionarily conserved noncoding RNAs with tissue-specific expression patterns, and exert unique cellular functions that have the potential to become biomarkers in therapeutic applications. Therefore, accurate and sensitive
Jiani Dong, Zhuoer Zeng, Ying Huang, Chuanpin Chen, Zeneng Cheng, Qubo Zhu   +5 more
semanticscholar   +1 more source

circRNA: a promising all-around star in the future.

Epigenomics, 2023
circRNA is a type of RNA molecule with a circular structure. From initially thinking it was useless to now discovering that it has important and complex functions, the importance of circRNA is increasingly being recognized.
Hanling Li
semanticscholar   +1 more source

CircRNA and Ageing

2023
Circular RNAs (circRNAs) are closed-loop RNA transcripts formed by a noncanonical back splicing mechanism. circRNAs are expressed in various tissues and cell types in a temporospatially regulated manner and have diverse molecular functions including their ability to act as miRNA sponges, transcriptional and splicing regulators, protein traps, and even ...
Ebrahim, Mahmoudi, Murray J, Cairns
openaire   +2 more sources

CircRNAs in diabetic cardiomyopathy

Clinica Chimica Acta, 2021
Diabetic cardiomyopathy is an important irreversible chronic cardiovascular complication in diabetic patients. This condition is described as early diastolic dysfunction, myocardial fibrosis, cardiac hypertrophy, systolic dysfunction and other complex pathophysiological events, which ultimately lead to heart failure.
Hengquan Wan, Simin Zhao, Qian Zeng, Yao Tan, Chi Zhang, Lingyun Liu, Shunlin Qu   +6 more
openaire   +3 more sources

The interaction of circRNAs and RNA binding proteins: An important part of circRNA maintenance and function

Journal of Neuroscience Research, 2020
The widespread expression of circular RNAs (circRNAs) is regarded as a feature of gene expression in highly diverged eukaryotes. Recent studies have shown that circRNAs can act as a miRNA sponge to repress miRNA function, participate in splicing of ...
Jiankun Zang, Dan Lu, Anding Xu
semanticscholar   +1 more source

CircRnas in atherosclerosis, with special emphasis on the spongy effect of circRnas on miRnas

Cell Cycle, 2022
Atherosclerosis (AS) is a chronic inflammatory disease, which leads to atherosclerotic rupture, lumen stenosis and thrombosis, and often endangers life. Circular RNAs (circRNAs) are a special class of non-coding RNA molecules, whose abnormal expression has been proved to be closely related to human diseases, including AS.
Chenglong Cheng, Yuting Wang, Qiuyun Xue, Yurong Huang, Xiao Wang, Faxue Liao, Chenggui Miao   +6 more
openaire   +2 more sources

CircRNAs in Plants

2018
Circular RNAs (circRNAs) are covalently closed, single-stranded transcripts that are ubiquitously expressed in all eukaryotes and even prokaryotic archaea. Although once regarded as splicing artifacts, circRNAs are a novel class of regulatory molecules with diverse biological functions, including regulation of transcription, modulation of alternative ...
Lai, Xuelei, Bazin, Jérémie, Webb, Stuart, Crespi, Martin, Zubieta, Chloe, Conn, Simon   +5 more
openaire   +5 more sources

CircRNAs and LncRNAs in Osteoporosis

Differentiation, 2020
Osteoporosis is a systemic bone disease with bone fragility and increased fracture risk. The non-coding RNAs (ncRNAs) have appeared as important regulators of cellular signaling and pertinent human diseases. Studies have demonstrated that circular RNAs (circRNAs) and long non-coding RNAs (lncRNAs) are involved in the progression of osteoporosis through
Wei Liu, Yancheng Zhong, Lihua Cao, Zi Zou, Ying Liu, Yuqing Mo, Cijun Shuai, Cijun Shuai, Haihua Wang, Tiantian He, Shuping Peng, Shuping Peng   +11 more
openaire   +3 more sources

CircRNA-mediated ceRNA mechanism in Osteoarthritis: Special emphasis on circRNAs in exosomes and the crosstalk of circRNAs and RNA methylation

Biochemical Pharmacology, 2023
Osteoarthritis (OA) is an age-related joint disease with chronic inflammation, progressive articular cartilage destruction and subchondral bone sclerosis. CircRNAs (circRNAs) are a class of non-coding RNA with a circular structure that participate in a series of important pathophysiological processes of OA, especially its ceRNA mechanisms, and play an ...
Qiuyun, Xue, Yurong, Huang, Jun, Chang, Chenglong, Cheng, Yuting, Wang, Xiaomei, Wang, Chenggui, Miao   +6 more
openaire   +2 more sources

A machine learning framework based on multi-source feature fusion for circRNA-disease association prediction

Briefings Bioinform., 2022
Circular RNAs (circRNAs) are involved in the regulatory mechanisms of multiple complex diseases, and the identification of their associations is critical to the diagnosis and treatment of diseases.
Lei Wang, Leon Wong, Zhengwei Li, Yuan Huang, Xiao-Rui Su, Bowei Zhao, Zhuhong You   +6 more
semanticscholar   +1 more source