Circular RNAs in Clear Cell Renal Cell Carcinoma: Their Microarray-Based Identification, Analytical Validation, and Potential Use in a Clinico-Genomic Model to Improve Prognostic Accuracy [PDF]
, 2019 Circular RNAs (circRNAs) may act as novel cancer biomarkers. However, a genome-wide evaluation of circRNAs in clear cell renal cell carcinoma (ccRCC) has yet to be conducted. Therefore, the objective of this study was to identify and validate circRNAs in
Erbersdobler, Andreas +9 more
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Circular RNA cancer vaccines drive immunity in hard-to-treat malignancies
Theranostics, 2022 Rationale: Messenger RNA (mRNA) vaccine outperforms other kinds of cancer immunotherapy due to its high response rates, easy preparation, and wide applicability, which is considered as one of the most promising forms of next-generation cancer therapies ...
Hongjian Li +8 more
semanticscholar +1 more source
Circular RNA—Is the Circle Perfect?
Biomolecules, 2021 Circular RNA (circRNA) is a distinct class of non-coding RNA produced, in principle, using a back-splicing mechanism, conserved during evolution, with increased stability and a tissue-dependent expression.
Lavinia Caba +4 more
doaj +1 more source
Experimental and Molecular Medicine, 2018 Spinal disease: Circular RNA linked to disc degeneration A circular RNA molecule helps protect against degenerative disc disease. Hua Wang and coworkers from Sun Yat-Sen University in Guangzhou, China, examined whether circular RNAs, regulatory molecules
Hua Wang +8 more
doaj +1 more source
Identification of G-quadruplex DNA/RNA binders: Structure-based virtual screening and biophysical characterization [PDF]
, 2017 Background Recent findings demonstrated that, in mammalian cells, telomere DNA (Tel) is transcribed into telomeric repeat-containing RNA (TERRA), which is involved in fundamental biological processes, thus representing a promising anticancer target. For
Alcaro, Stefano +11 more
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Engineering circular RNA for potent and stable translation in eukaryotic cells
Nature Communications, 2018 Messenger RNA (mRNA) has broad potential for application in biological systems. However, one fundamental limitation to its use is its relatively short half-life in biological systems.
A. Wesselhoeft +2 more
semanticscholar +1 more source
Characterizing Expression and Regulation of Gamma-Herpesviral Circular RNAs
Frontiers in Microbiology, 2021 Multiple herpesviruses have been recently found to encode viral circular RNAs. Like cellular circular RNAs, these RNAs lack poly-A tails and their 5′ and 3′ ends have been joined, which confers protection from RNA exonucleases. We examined the expression
Takanobu Tagawa +10 more
doaj +1 more source
Circular RNA vaccine induces potent T cell responses
Proceedings of the National Academy of Sciences of the United States of America, 2023 Significance Circular RNAs (circRNAs) are a unique class of RNAs that are highly stable compared to linear mRNAs and can be engineered to provide durable protein expression.
Laura Amaya +6 more
semanticscholar +1 more source
Circular RNA: A promising new star of vaccine
Journal of Translational Internal Medicine, 2023 Circular RNAs (circRNAs) are a class of single-stranded RNAs with covalently closed structures. Owing to their not having 3' or 5' ends, circRNAs are highly durable and insusceptible to exonuclease-mediated degradation.
Jindong Xie +10 more
semanticscholar +1 more source
Search for virus specific DNA sequences and viral particles in mitochondria of avian leukemic myeloblasts [PDF]
, 1977 The intracellular localization of the avian myeloblastosis virus (AMV) genome was studied. Nuclear and mitochondrial DNAs from myeloblasts were examined by hybridization with 32P labeled AMV-RNA of high molecular weight for the presence of virus specific
Oda, Takuzo, Ogura, Hajime
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