Results 241 to 250 of about 761,097 (299)

Phosphorylated STYK1 Promotes Gemcitabine Resistance via Autophagy‐Mediated Cancer Stemness in Pancreatic Cancer

Advanced Science, EarlyView.
Gemcitabine resistance remains a major challenge in pancreatic ductal adenocarcinoma. This study identifies STYK1 as a key mediator of chemoresistance through autophagy‐dependent maintenance of cancer stemness. Gemcitabine‐activated AMPK phosphorylates STYK1 at Ser91 and Ser304, enhancing autophagy and stemness.
Xueying Dong, Shi Li, Chensong Huang, Xuehong Qian, Jieyu Guo, Yahao Guo, Guifang Wu, Qi Zhang, Hongfei Tan, Yu Han, Rui Zhang, Hao Lyu, Shuai Xiao, Dong Guo, Chaojun Yan, Wenying Qin, Changchun Li, Xing‐Zhen Chen, Ying Zhao, Cefan Zhou, Jingfeng Tang   +20 more
wiley   +1 more source

Circular RNAs in obesity and related metabolic disorders: mechanistic insights and therapeutic perspectives. [PDF]

Front Genet
Bernal-Vázquez D, Bolaños-Fernández I, Salcedo-Rivas GO, Figueroa-Ramírez M, Duttaroy AK, Paul S.   +5 more
europepmc   +1 more source

Charting Endocrine Progenitors Across Species and Organs

Advanced Science, EarlyView.
Endocrine progenitors give rise to the hormone‐producing cells of the pancreas and intestine. Using single‐cell multiomics and proteomics, this study compares these progenitors across species, systems, and organs, mapping the conserved and species‐specific gene regulatory networks that guide their formation.
Changying Jing, Michael Sterr, Özüm Sehnaz Caliskan, Lama Saber, Nicole Katarina Rogers, Samuel Ogden, Kei Kozawa, Christos Karampelias, Jessica Jaki, Aimée Bastidas‐Ponce, Falk Janos Farkas, Oliver Czarnecki, Osvaldo Rodrigues Pereira, Perla Cota, Valerie Vandenbempt, Diego Balboa, Anika Böttcher, Natalie Krahmer, Mohammad Lotfollahi, Julie B. Sneddon, Heiko Lickert, Mostafa Bakhti   +21 more
wiley   +1 more source

Recent Studies on Kaposi's Sarcoma-Associated Herpesvirus Circular RNAs. [PDF]

Cancers (Basel)
Pagtalunan CJ, Zhang I, Turley A, Liu F.
europepmc   +1 more source

Functions and mechanisms of circular RNAs in cancer stem cells and therapy resistance. [PDF]

Front Cell Dev Biol
Yuan Y, Zhang D, Wang J, Jiang X, Duan L.   +4 more
europepmc   +1 more source

Characterization of circular RNAs in mammary tissue from Holstein cows at perinatal period and dry period. [PDF]

Front Genet
Liang Y, Gu S, Zhang Z, Wang Y, Li M, Karrow NA, Hua J, Mao Y.   +7 more
europepmc   +1 more source

A Divergent TaqMan RT-qPCR Strategy for Isoform-Resolved Detection of HIV-1 Circular RNAs. [PDF]

Methods Protoc
Mauer C, Paz S, Caputi M.
europepmc   +1 more source

The emerging role of circular RNAs in neuropsychiatric disorders. [PDF]

Transl Psychiatry
Huang S, Song Z, Pan J, Luo Y, Chen Y.
europepmc   +1 more source

Circular RNAs: Key Regulators of Tumor Metabolic Reprogramming and Clinical Translation. [PDF]

Oncol Res
Wu Y, Liu Y, Sun R, Zhang Y, Zhang Q, Li C, Li M.   +6 more
europepmc   +1 more source

Mechanism of translation initiation on endogenous eukaryotic circular RNAs

Zuber PK, Li X, Du Y, Gordiyenko Y, Haddad TF, Ramakrishnan V.   +5 more
europepmc   +1 more source