Results 261 to 270 of about 761,097 (299)

An Overview of Circular RNAs

2018
Circular RNAs (cirRNAs) are long, noncoding endogenous RNA molecules and covalently closed continuous loop without 5'-3' polarity and polyadenylated tail which are largely concentrated in the nucleus. CirRNA regulates gene expression by modulating microRNAs and functions as potential biomarker.
Awasthi, Rajendra, Singh, Anurag Kumar, Mishra, Gaurav, Maurya, Anand, Chellappan, Dinesh Kumar, Gupta, Gaurav, Hansbro, Philip Michael, Dua, Kamal   +7 more
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Circular RNA in cancer

Nature Reviews Cancer
Over the past decade, circular RNA (circRNA) research has evolved into a bona fide research field shedding light on the functional consequence of this unique family of RNA molecules in cancer. Although the method of formation and the abundance of circRNAs can differ from their cognate linear mRNA, the spectrum of interacting partners and their ...
Vanessa M. Conn, Arul M. Chinnaiyan, Simon J. Conn   +2 more
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An Overview of Circular RNAs

Circular RNAs (circRNAs) are a class of endogenous, covalently closed RNA molecules. Unlike linear RNAs, circRNAs are formed through noncanonical splicing, during which a downstream donor site is ligated with an upstream splice acceptor site, building a backsplice junction (BSJ), the distinguishing feature of circRNAs.
Julia, Mester-Tonczar, Ena, Hasimbegovic
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Circular RNAs in Blood

2018
Recent advances in RNA sequencing and bioinformatic analysis have allowed the development of a new research field: circular RNAs (circRNAs). These members of the non-coding transcriptome are generated by backsplicing, which results in a covalently closed, single-stranded RNA molecule.
Vea, A, Llorente-Cortes, V, de Gonzalo-Calvo, D   +2 more
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Formation of Circular RNAs

Circular RNAs (circRNAs) constitute a class of covalently closed, single-stranded RNA molecules that form a continuous loop structure, setting them apart from linear RNA molecules. These circular entities arise through a distinct biogenetic process termed "backsplicing," which involves the covalent bonding of the 5' site of an upstream exon with the 3'
Arvind, Srinivasan, Marzena, Wojciechowska   +1 more
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Methods for circular RNAs

Methods, 2021
Ling-Ling, Chen, Jeremy E, Wilusz
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Circular RNA

Nature Biotechnology, 2021
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Circular RNAs and Cancers

Circular RNAs (circRNAs) are a recently discovered type of endogenous RNA molecules that are formed through the back-splicing process of exons in precursor messenger RNAs (pre-mRNAs), resulting in a unique covalently closed circular structure. CircRNAs are just beginning to be acknowledged for their roles as microRNA sponges and protein scaffolds ...
Mohammad Mahdi, Heidari, Mohammad Saeid, Moeinfar, Mahdi, Rafiyan, Parsa, Sepehri, Ameneh, Jafari, Arash, Raisi, Fatemeh, Aslanbeigi, Ashkan, Bahrami, Maryam Nasr, Azadani, Neda, Rahimian, Maryam, Mahjoubin-Tehran, Hamed, Mirzaei   +11 more
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Characterization of Circular RNA Concatemers

2018
Circular RNAs (circRNAs) constitute a novel subset in the fascinating world of noncoding RNA, and they are found in practically all eukaryotes. Most of them exhibit low expression levels but some are extremely abundant. Typically, circRNAs are studied by RT-PCR-based assays, but for certain types of analyses this technique is not suitable. Circular RNA
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Circular RNAs and Neuronal Development

2018
Circular RNAs (circRNAs) are abundant in the brain and are often expressed in complex spatiotemporal patterns that coincide with distinct developmental transitions. This suggests that circRNAs play a significant role in the central nervous system. This book chapter will review research progress into the function of circRNAs during neuronal development.
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