Results 91 to 100 of about 256,540 (247)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Nucleosomes in serum as a marker for cell death [PDF]

, 2001
The concentration of nucleosomes is elevated in blood of patients with diseases which are associated with enhanced cell death. In order to detect these circulating nucleosomes, we used the Cell Death Detection-ELISA(Plus) (CDDE) from Roche Diagnostics ...
Holdenrieder, Stefan, Dietrich Seidel, Seidel, Dietrich, Michael Untch, Fertig, Georg, Stieber, Petra, Fürst, Heinrich, Georg Fertig, Nikolaus Schmeller, Heinz Bodenmüller, Stefan Holdenrieder, Schmeller, Nikolaus, Heinrich Fürst, Bodenmüller, Heinz, Untch, Michael, Petra Stieber   +15 more
core   +1 more source

Dysregulation of circulating damage-associated molecular patterns in diabetic foot syndrome

Frontiers in Immunology
BackgroundDiabetic foot syndrome (DFS) is characterized by chronic inflammation, thrombotic imbalance, and impaired wound healing, yet systemic molecular alterations underlying this complication remain incompletely defined.
Elena Uyy, Viorel-Iulian Suica, Luminita Ivan, Raluca Maria Boteanu, Diana Valentina Uta, Elena Georgiana Bernea, Dragoş Eugen Georgescu, Ovidiu Chiriac, Maya Simionescu, Felicia Antohe   +9 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Astrocyte heterogeneity in brain metastases

Molecular Oncology, EarlyView.
Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver, Neibla Priego, Manuel Valiente   +2 more
wiley   +1 more source

The relationship between the insulin-like growth factor-1 axis, weight loss, an inflammation-based score and survival in patients with inoperable non-small cell lung cancer [PDF]

, 2010
<b>Background & aims:</b> The involvement of a systemic inflammatory response, as evidenced by the Glasgow Prognostic Score (GPS), is associated with weight loss and poor outcome in patients with non-small cell lung cancer.
Meek, C.L., Wallace, A.M., McMillan, D.C., Forrest, L.M.   +3 more
core   +1 more source

From tumor‐centric to ecosystem‐based hypotheses in brain tumor research and care

Molecular Oncology, EarlyView.
Primary brain tumors, whether in adults or children, present a major challenge because of their dramatic prognosis and the ongoing lack of efficient therapeutic approaches. In recent years, a shift has occurred from tumor‐centric concepts to a more holistic view of these tumors as dynamic ecosystems.
Julie Gavard, Flavie Bénard, Eva Billat, Margaux Le Guyon, Victoria Maltret, Laura Merlet, Chloé Astrid Walter, Tony Avril, Eric Chevet   +8 more
wiley   +1 more source

The Inflammatory-Immune Axis in Thyroid Disease: A Mendelian Randomization Study

International Journal of Endocrinology
Conclusion: The study establishes a causal relationship between circulating inflammatory proteins and immune cells in relation to GD, with immune cells serving as intermediaries in the pathway between inflammatory proteins and GD risk.
Tao Pan, Zhihao Fang, Titi Hui, Xuanlin Wu, Xu Hu, Jiabin You, Chang Liu   +6 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Deciphering the role of circulating inflammatory proteins in myocarditis: Novel strategies for targeted therapy

International Journal of Cardiology
Myocarditis is closely linked to immune dysregulation, yet the causal roles of circulating inflammatory proteins in its development remain incompletely understood. This study aimed to explore whether specific inflammatory proteins are causally associated with myocarditis and to assess their potential translational relevance.We applied a two-sample ...
Zhiyu, Zhang, Zeye, Liu, Ke, Li, Haiyang, Xie, Hailu, Wang, Qi, Li, Fajar, Prasetya, Xi, Chen, Yifan, Chen, Yiyin, Zhang   +9 more
openaire   +2 more sources