Results 81 to 90 of about 256,540 (247)
Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns +10 morewiley +1 more sourceA Genome-Wide Association Study Reveals Variants in ARL15 that Influence Adiponectin Levels [PDF]
, 2009 The adipocyte-derived protein adiponectin is highly heritable and inversely associated with risk of type 2 diabetes mellitus (T2D) and coronary heart disease (CHD). We meta-analyzed 3 genome-wide association studies for circulating adiponectin levels (n =Stewart, A.F.R., Stewart, AFR, O'Rahilly, S. (Stephen), Epstein, S.E., Pastinen, Tomi, Samani, NJ, O'Rahilly, S., Abecasis, Gonçalo R., Witteman, JC, Langenberg Claudia, Hall, A.S. (Alistair), Beate Glaser, Kijoung Song, Hengstenberg, Christian, Stephen E Epstein, Ruth J. F. Loos, Evans, D, Daniel J Rader, Witteman, J., Wichmann, H.-E., Willenborg, C., Toshiko Tanaka, Mary-Susan Burnett, Stark, K, Hingorani Aroon, König, Inke R, Langenberg, C, Samani, N., Van Duijn, C.M., Stark, K. (Klaus), Peter Vollenweider, Stark Klaus, Willenborg, C. (Christina), Robert K. Semple, Evans, D., Davey Smith George, Van Duijn, CM, Richards, J.B., Erdmann Jeanette, Loos, Ruth J F, Grassl, M., Josephine M. Egan, Davey Smith, George, Perry, John R. B., Wichmann, H.E., Frayling, Timothy M., Sladek, R. (Rob), Wichmann, H.E. (Heinz Erich), Barter Phil, Stewart Alexandre F. R., Mooser, Vincent, Waeber Gerard, John R Thompson, Vollenweider Peter, Reinhard, W, Ricketts Sally L., Waterworth, D. (Dawn), Meigs, J., Stark, Klaus, Davey Smith, G., Wichmann, H-Erich, Willenborg, Christina, Melzer, D, Pastinen, T., Reilly Muredach P., Rocha, Nuno, Hivert, MF, Thompson, J., Sattar, N, Smith, GD, Barter, P., König, I.R. (Inke), Winogradow, J, Meigs, JB, Stewart, Alexandre F.R., Reinhard, W. (Wibke), Semple, Robert K.; id_orcid, Nicholas John Timpson, Hall, AS, Ferrucci, L. (Luigi), Hivert, M., Scott Grundy, Christina Willenborg, ?, ?, Naveed Sattar, Witteman, Jaquelin C. M, Hall, A., Duijn, Cornelia, Florez, Jose, Sladek, R, Van Duijn Cornelia M., Saxena, R, Reilly, Muredach P., Soranzo, N. (Nicole), Melzer, David, Mahley Robert, Glaser, B, Prokopenko, Inga, Christian Hengstenberg, Schunkert, H, Dupuis, Josee, Loos, R.J.F. (Ruth), Wareham, N.J. (Nick), Aulchenko, Y, Koenig, Inke R., George Davey Smith, Loos, Ruth J.F., Thompson, JR, Frayling Timothy M., Barter, Phil, Deloukas Panos, Aulchenko Yurii, Sladek, Robert, Hengstenberg, C. (Christian), Wareham, N.J., Schunkert, H., Marie-France Hivert, Glaser Beate, John R B Perry, Reilly, M.P. (Muredach), Nicholas J Wareham, Claudia Langenberg, Timothy M, Rader Daniel J., Thompson, John R, McPherson, R. (Ruth), Erdmann, Jeanette, Spector, T., Vincent Mooser, Thompson, John R., O'Rahilly, Stephen, Loos, Ruth J. F., Josée Dupuis, Rader, D.J. (Daniel), Burling, K.A. (Keith), Tim D Spector, Ferrucci, L, Erdmann, J., Jose C. Florez, Konig, IR, Loos, RJF, Reilly, M., Tomi Pastinen, Dupuis, J, Luigi Ferrucci, Burnett, M., McPherson, R, Reilly, MP, Alexandre F R Stewart, H-Erich Wichmann, Brent Richards, J., Deloukas, P., Inke R. König, Egan, JM, Hivert Marie-France, Ferrucci Luigi, Mooser, V. (Vincent), Erdmann, J, Keith Burling, Grundberg, E, Burling, K, Frayling, T.M. (Timothy), Muredach P. Reilly, Grundy, S.M. (Scott), Kesaniemi, Y Antero, Burnett, MS, Waterworth, Dawn, Wareham, NJ, Consortium, GIANT, Waterworth, D, Egan, J., Frayling, TM, Waterworth, D., Perry, J.R.B. (John), Janina Winogradow, Meigs, James B., Evans, David, Martina Grassl, Waeber, Gerard, Ruth J F Loos, Semple, Robert K., Witteman Jaquelin C. M., Wareham, N., Samani, N.J. (Nilesh), Winogradow, Janina, Grundy, S, Rader, D., Cornelia M. Van Duijn, Deloukas, Panos, Rocha, N. (Nuno), Prokopenko Inga, Wareham, Nicholas J., Grundberg Elin, Van Duijn, C., Grundy, Scott, Barter, P. (Phil), Deanfield, J., Meigs, J.B., Tikka-Kleemola, P. (Päivi), Perry, J.R.B., Hengstenberg Christian, McPherson Ruth, Rader, DJ, Epstein Stephen E., Burnett, Mary-Susan, Smith, A.V. (Davey), Egan, J.M., Hivert, Marie-France, Burnett Mary-Susan, Witteman, Jaquelin C M, Willenborg, C, James B Meigs, Timpson Nicholas John, Alistair S Hall, Vollenweider, P, Stewart, Alexandre F. R., Hingorani, A, Soranzo Nicole, Dupuis, J. (Josée), Mahley, R, Spector, TD, Elin Grundberg, Semple, R.K., Grassl, M. (Martina), Tanaka, T, Aulchenko, Y.S. (Yurii), Grundberg, E. (Elin), Stewart, A.F.R. (Alexandre), GIANT Consortium, Burnett, M.-S., Panos Deloukas, Consortium, G., Dupuis Josée, Ferrucci, L., Robert Mahley, Waterworth Dawn, David Melzer, Richards, J Brent, Deanfield, John, Reinhard Wibke, Tanaka, T., Kesaniemi, YA, Deloukas, P, Winogradow, J., Florez Jose C., Reinhard, W., Devaney, J., Glaser, B., Song, K. (Kijoung), Ruth McPherson, Meigs, J.B. (James), Kesaniemi, Y., Tanaka Toshiko, Kesaniemi, Y. Antero, Reinhard, Wibke, Josephine M Egan, Hall, Alistair S., Samani, Nilesh J., Prokopenko, I. (Inga), Song, K, Langenberg, Claudia, Vollenweider, P., Winogradow, J. (Janina), Waeber, G. (Gérard), Sattar Naveed, Pastinen, T, Ferrucci, Luigi, Soranzo, N, Sladek Robert, Ricketts, S.L. (Sally), Wibke Reinhard, Sattar, Naveed, O'Rahilly Stephen, Spector, Tim D., Jeanette Erdmann, Richards, J.B. (Brent), Schunkert Heribert, Grundberg, Elin, Burnett, M.S., Rocha Nuno, Devaney Joseph, Florez, Jose C, Egan Josephine M., Hingorani, Aroon, Egan, Josephine M., Phil Barter, Hengstenberg, C, Inga Prokopenko, Stark, K., Hingorani, A., Erdmann, J. (Jeanette), Joseph Devaney, Timothy M Frayling, Frayling, T., Epstein, SE, J. Brent, Thompson, J.R., Perry, J., Samani, N.J., Rader, Daniel J., David Evans, Soranzo, N., Epstein, S., Waeber, G., Pastinen, T. (Tomi), Winogradow Janina, Glaser, Beate, Perry, JR, Wichmann, HE, Florez, J.C., Epstein, S.E. (Stephen), Wichmann, H., Semple Robert K., Sladek, R., Alistair S. Hall, Davey Smith, G, Y Antero Kesaniemi, Gerard Waeber, Thompson, J.R. (John), Perry, John R.B., Wichmann H-Erich, Egan, Josephine M, Richards, J. Brent, Semple, Robert K, Kesaniemi, Y.A. (Antero), Tanaka, T. (Toshiko), Saxena Richa, Egan, J.M. (Josephine), Saxena, Richa, Florez, J.C. (Jose), Burling Keith, Mooser Vincent, Timpson, Nicholas John, Van Duijn, Cornelia M., Timpson, NJ, Ricketts, SL, Epstein, Stephen E., Spector Tim D., Semple, R., Aulchenko, Yurii S., Nilesh J. Samani, Rocha, N, Devaney, Joseph, Prokopenko, I, Thompson John R., Florez, J., Richards J. Brent, Yurii Aulchenko, Aulchenko, Y., Saxena, R., Samani Nilesh J., Semple, RK, Mooser, V, Sattar, N. (Naveed), Ricketts, Sally L, Song, K., Grundberg, E., Langenberg, C., Ricketts, S., J. Brent Richards, Muredach P Reilly, Florez, JC, Smith, George Davey, Spector, T.D. (Timothy), Cornelia M Van Duijn, Kesaniemi, Y.A., Vollenweider, Peter, Saxena, R. (Richa), Perry, JRB, Wareham Nicholas J., John Deanfield, Prokopenko, I., Soranzo, Nicole, Burling, Keith, Witteman, JCM, Rader, D.J., Melzer David, Grassl, M, König, I.R., Perry John R. B., Stewart, A., Devaney, J. (Joseph), Song Kijoung, Sattar, N., Witteman, Jaquelin C.M., Mahley, R., Dawn Waterworth, John R. Thompson, Melzer, D. (David), Melzer, D., Evans, D.M. (David), Loos, R., Hingorani, A. (Aroon), Re F. R. Stewart, Mooser, V., Stephen E. Epstein, Pastinen Tomi, Richa Saxena, Mahley, R. (Robert), König, I., König, Inke R., Timpson, N., Nuno Rocha, Nicole Soranzo, Hengstenberg, C., Grundy Scott, Hivert, M.-F., Loos, RJ, O'Rahilly, S, Sally L Ricketts, Loos Ruth J. F., Barter, P, Stewart, AF, Wichmann, Heinz-Erich, Robert K Semple, Devaney, J, Mahley, Robert, Ricketts, Sally L., Heribert Schunkert, Klaus Stark, John R. B. Perry, Deanfield John, Schunkert, H. (Heribert), McPherson, Ruth, Tanaka, Toshiko, Dupuis, J., J Brent Richards, Aroon Hingorani, Inke R König, Daniel J. Rader, Song, Kijoung, Hivert, M.-F. (Marie-France), Jaquelin C M Witteman, Grassl, Martina, Schunkert, Heribert, Spector, T.D., Loos, R.J.F., Hall, Alistair S, Grassl Martina, Waeber, G, Semple, R.K. (Robert), Hall, A.S., Grundy, S., Florez, Jose C., Witteman, Jaquelin C. M., Perry, John R B, Frayling, T.M., Y. Antero Kesaniemi, Jose C Florez, Sally L. Ricketts, Evans David, Rocha, N., Willenborg Christina, Robert Sladek, Aulchenko, Yurii, Stephen O'Rahilly, Citation Richards, Meigs, James, Kesaniemi Y. Antero, Witteman, J.C.M. (Jacqueline), Richards, J., Timpson, N.J. (Nicholas), Deanfield, J. (John), Meigs James B., Aulchenko, Yuriy, Witteman, J.C.M., Glaser, B. (Beate), Richards, JB, König Inke R., Vollenweider, P. (Peter), Burling, K., Deanfield, J, McPherson, R., Deloukas, P. (Panagiotis), Nilesh J Samani, Timpson, N.J., Langenberg, C. (Claudia), Hall Alistair S., Reilly, M.P., Jaquelin C. M. Witteman, Ricketts, S.L. +480 morecore +1 more sourceHijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...Gabriela Marinescu, Yi Fengwiley +1 more sourceESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study
Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou +12 morewiley +1 more sourceAssociation between circulating inflammatory proteins and temporomandibular disorders: insight from a two-sample Mendelian randomization analysis [PDF]
Background Past studies have indicated links between specific inflammatory proteins in the bloodstream and temporomandibular disorders (TMDs). Nonetheless, there remains the need for further solid research pinpointing the exact causes behind these ...Jiang, Feng, Ding, Ao, Wu, Chu-Yan, Yu, Chan-Yuan, Zhao, Jun +4 morecore +1 more sourceExploring potential causal effects of circulating inflammatory proteins on hematologic malignancies and identifying cross-cancer drug targets: a Mendelian randomization study
HematologyBackground: Although a substantial body of research has underscored the pivotal role of inflammatory proteins in hematologic malignancies, precise understanding of the underlying mechanisms is limited.Chaoqun Lu, Minghui Wang, Jiang Li, Huajian Xian, Zixuan Huang, Yixin Wang, Shufeng Xie, Wenjie Zhang, YaoYifu Yu, Huijian Zheng, Dan Li, Yuling Zheng, Han Liu, Chunjun Zhao +13 moredoaj +1 more source
