Results 91 to 100 of about 6,520,232 (298)

Detection of FAM172A expressed in circulating tumor cells is a feasible method to predict high-risk subgroups of colorectal cancer

Tumor Biology, 2017
Previous studies used to enumerate circulating tumor cells to predict prognosis and therapeutic effect of colorectal cancer. However, increasing studies have shown that only circulating tumor cells enumeration was not enough to reflect the heterogeneous ...
Chun-Hui Cui, Ri-hong Chen, Duan-Yang Zhai, Lang Xie, Jia Qi, Jin-Long Yu   +5 more
doaj   +1 more source

Effect of Change in Circulating Tumor Cell Counts in Predicting Postoperative Recurrence and Metastasis of Localized Renal Carcinoma

Zhongliu Fangzhi Yanjiu, 2020
Objective To explore the role of the change in circulating tumor cell counts in predicting the recurrence and metastasis of localized renal cancer after partial nephrectomy. Methods The included 41 patients were divided into positive(n=23) and negative(n=
CHEN Tao, LI Li, YAO Qisheng, LI Hao, CHEN Congbo, YANG Yong, WANG Li   +6 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Denosumab treatment is associated with the absence of circulating tumor cells in patients with breast cancer

Breast Cancer Research, 2018
Background The presence of circulating tumor cells (CTCs) in patients with breast cancer correlates to a bad prognosis. Yet, CTCs are detectable in only a minority of patients with progressive breast cancer, and factors that influence the abundance of ...
Marcus Vetter, Julia Landin, Barbara Maria Szczerba, Francesc Castro-Giner, Sofia Gkountela, Cinzia Donato, Ilona Krol, Ramona Scherrer, Catharina Balmelli, Alexandra Malinovska, Alfred Zippelius, Christian Kurzeder, Viola Heinzelmann-Schwarz, Walter Paul Weber, Christoph Rochlitz, Nicola Aceto   +15 more
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Circulating tumor cells and clusters as liquid biomarkers for the diagnosis and prognosis of neuroblastoma

BMC Cancer
Background The clinical significance of circulating tumor cell (CTC) clusters in highly metastatic tumors hasn’t yet been revealed. Here, we demonstrated the diagnostic and prognostic value of CTC clusters in neuroblastoma (NB) which is the most ...
Huanli Xu, Nianhua Cao, Wenyan Dai, Caiwei Sima, Meng Yi, Senmin Chen, Xiaowen Chen, Chao Liu, Uet Yu, Huiping Lang, Zhedie Zhou, Nanlin Yang, Chunjing Wang, Xianping Jiang, Yungen Gan, Jianyao Wang, Yuanxiang Wang, Nuaner Yao, Lidan Xiao, Qing Zhang, Junjie Sun, Zhou Lin, Gongwei Zhang, Jiayue Zhang, Hongtao Feng, Jianming Song, Sixi Liu, Zongbin Liu, Feiqiu Wen, Xiuli Yuan   +29 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Current status of liquid biopsies for the detection and management of prostate cancer

Cancer Management and Research, 2019
Yi-Tsung Lu, Kevin Delijani, Andrew Mecum, Amir GoldkornDivision of Medical Oncology, Department of Medicine, Keck School of Medicine and Translational and Clinical Science Program, USC Norris Comprehensive Cancer Center, University of Southern ...
Lu YT, Delijani K, Mecum A, Goldkorn A
doaj  

Detection of circulating tumor cells by cell block technique in malignant tumors

Journal of Cytology
Introduction: Cancer is a leading cause of death worldwide and is a major cause of morbidity. To deal with this magnitude of cancers and their diagnostic and prognostics, a multitude of prognostic biomarkers for various cancers have been explored over ...
Jahnvi Vijay, B Deepak Kumar, V Srinivasa Murthy   +2 more
doaj   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source