Results 91 to 100 of about 6,088,596 (303)
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Detection of Circulating Tumor Cells and Circulating Tumor Microemboli in Gastric Cancer
Translational Oncology, 2017 Gastric cancer studies indicated a potential correlation between circulating tumor cells (CTCs) in peripheral blood and tumor relapse/metastasis. The prevalence and significance of circulating tumor microemboli (CTM) in gastric cancer remain unknown. We investigated the prevalence and prognostic value of CTCs and CTM for progression-free survival (PFS)
Xiumei Zheng +12 more
openaire +3 more sources
Pro- and anti-inflammatory cytokines in threatened miscarriages [PDF]
, 2011 OBJECTIVE: The purpose of this study was to evaluate circulating and intracellular levels of Th1 and Th2 cytokines in women with threatenedmiscarriage (TM) and subsequent outcome.
Jean Calleja-Agius +7 more
core +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Tumor antigen cross-presentation and the dendritic cell: Where it all begins? [PDF]
, 2010 Dendritic cells (DCs) are professional antigen-presenting cells (APCs) that are critical for the generation of effective cytotoxic T lymphocyte (CTL) responses; however, their function and phenotype are often defective or altered in tumor-bearing hosts ...
McDonnell, A.M. +2 more
core
Technical Aspects for the Evaluation of Circulating Nucleic Acids (CNAs): Circulating Tumor DNA (ctDNA) and Circulating MicroRNAs [PDF]
, 2017 Circulating nucleic acids (CNAs), for example, circulating tumor DNA (ctDNA) and circulating microRNA (miRNA), represent promising biomarkers in several diseases including cancer.
CIACCIO, Marcello +11 more
core +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Circulating tumor cells and beyond [PDF]
, 2018 As cancer progresses, tumor cells can travel through the blood circulation to form metastasis. These circulating tumor cells (CTC) can be used as a liquid biopsy for the real-time information they carry about the tumor. They can be isolated from blood using the EpCAM molecule for enrichment.
openaire +2 more sources
Quantifying metastatic inefficiency:rare genotypes versus rare dynamics [PDF]
, 2014 We introduce and solve a 'null model' of stochastic metastatic colonization. The model is described by a single parameter ?: the ratio of the rate of cell division to the rate of cell death for a disseminated tumour cell in a given secondary tissue ...
Newman, Timothy J., Cisneros, Luis H.
core +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source