Results 111 to 120 of about 493,161 (298)

Current status of liquid biopsies for the detection and management of prostate cancer

Cancer Management and Research, 2019
Yi-Tsung Lu, Kevin Delijani, Andrew Mecum, Amir GoldkornDivision of Medical Oncology, Department of Medicine, Keck School of Medicine and Translational and Clinical Science Program, USC Norris Comprehensive Cancer Center, University of Southern ...
Lu YT, Delijani K, Mecum A, Goldkorn A
doaj  

Detection of circulating tumor cells by cell block technique in malignant tumors

Journal of Cytology
Introduction: Cancer is a leading cause of death worldwide and is a major cause of morbidity. To deal with this magnitude of cancers and their diagnostic and prognostics, a multitude of prognostic biomarkers for various cancers have been explored over ...
Jahnvi Vijay, B Deepak Kumar, V Srinivasa Murthy   +2 more
doaj   +1 more source

Single-cell analyses of circulating tumor cells

Cancer Biology & Medicine, 2015
Circulating tumor cells (CTCs) are a population of tumor cells mediating metastasis, which results in most of the cancer related deaths. The number of CTCs in the peripheral blood of patients is rare, and many platforms have been launched for detection ...
Xi-Xi Chen, Fan Bai
doaj   +1 more source

Kras mutation correlating with circulating regulatory T cells predicts the prognosis of advanced pancreatic cancer patients

Cancer Medicine, 2020
Purpose Kras mutation and abnormal immune status are associated with pancreatic cancer development and progression. In this study, we evaluated the Kras mutation status in circulating tumor DNA and circulating T cell subsets in a cohort of advanced ...
He Cheng, Guopei Luo, Kaizhou Jin, Zhiyao Fan, Qiuyi Huang, Yitao Gong, Jin Xu, Xianjun Yu, Chen Liu   +8 more
doaj   +1 more source

The non-coding RNA landscape of plasma cell dyscrasias [PDF]

, 2020
Despite substantial advancements have been done in the understanding of the pathogenesis of plasma cell (PC) disorders, these malignancies remain hard-to-treat.
Azab, Kareem A, et al,, Morelli, Eugenio, Rocca, Roberta   +3 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Cell-free circulating tumor DNA in cancer

Chinese Journal of Cancer, 2016
Cancer is a common cause of death worldwide. Despite significant advances in cancer treatments, the morbidity and mortality are still enormous. Tumor heterogeneity, especially intratumoral heterogeneity, is a significant reason underlying difficulties in
Zhen Qin, Vladimir A. Ljubimov, Cuiqi Zhou, Yunguang Tong, Jimin Liang   +4 more
doaj   +1 more source

Cancer cells exploit an orphan RNA to drive metastatic progression. [PDF]

, 2018
Here we performed a systematic search to identify breast-cancer-specific small noncoding RNAs, which we have collectively termed orphan noncoding RNAs (oncRNAs).
A Fabregat, A Helwak, AA Margolin, AJ Minn, Alicia Y. Zhou, AM Ainsztein, Andrei Goga, AR Kodahl, AR Quinlan, B Kim, B Langmead, Bruce Culbertson, C Roth, CI Wu, CJ David, D Huo, D Ray, DK Simanshu, DN Cooper, EL Nostrand Van, H Goodarzi, H Goodarzi, H Goodarzi, H Goodarzi, Hani Goodarzi, JM Loo, Johnny X. Yu, K Cuk, L Fish, Lisa Fish, LY Chen, M Rehmsmeier, MI Love, MJ Moore, NN Hooten, O Elemento, PD Bos, R Bhargava, R Ren, RK Lin, RO Bak, S Kishore, S Vanharanta, SF Tavazoie, Steven Zhang, T Fiskaa, W Zhou, X Wu, YCT Yang, YS DeRose   +49 more
core   +2 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Alone you go faster, together you go farther

Molecular Oncology
The metastatic process is an extraordinarily complex step‐by‐step procedure, characterized by many analogies with migratory patterns of humans or animals across our planet. The ongoing interrogation of circulating tumor cells (CTCs), caught in the act of
Nicola Aceto
doaj   +1 more source