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Label‐Free Microfluidic Apheresis of Circulating Tumor Cell Clusters [PDF]

Advanced Science
Screening liters of blood (i.e., apheresis) represents a generalized approach to promote the reliable access to circulating tumor cell clusters (CTCCs), which are known to be highly metastasis‐competent, yet ultrarare.
Li Zhan, Jon Edd, Avanish Mishra, Mehmet Toner   +3 more
doaj   +4 more sources

Microfluidic Isolation of Circulating Tumor Cell Clusters by Size and Asymmetry [PDF]

Scientific Reports, 2017
Circulating tumor cell clusters (CTC clusters) are potent initiators of metastasis and potentially useful clinical markers for patients with cancer. Although there are numerous devices developed to isolate individual circulating tumor cells from blood ...
Sam H. Au, Jon Edd, Amy E. Stoddard, Keith H. K. Wong, Fabio Fachin, Shyamala Maheswaran, Daniel A. Haber, Shannon L. Stott, Ravi Kapur, Mehmet Toner   +9 more
doaj   +7 more sources

Evaluation of circulating tumor cell clusters for pan-cancer noninvasive diagnostic triaging. [PDF]

Cancer Cytopathol, 2021
BackgroundHistopathologic examination (HPE) of tumor tissue obtained by invasive biopsy is the standard for cancer diagnosis but is resource‐intensive and has been associated with procedural risks. The authors demonstrate that immunocytochemistry (ICC) profiling of circulating ensembles of tumor‐associated cells (C‐ETACs) can noninvasively provide ...
Gaya A, Crook T, Plowman N, Ranade A, Limaye S, Bhatt A, Page R, Patil R, Fulmali P, Datta V, Kumar P, Patil D, Akolkar D.   +12 more
europepmc   +5 more sources

Cancer-specific calcium nanoregulator suppressing the generation and circulation of circulating tumor cell clusters for enhanced anti-metastasis combinational chemotherapy [PDF]

Acta Pharmaceutica Sinica B, 2021
Tumor metastasis is responsible for chemotherapeutic failure and cancer-related death. Moreover, circulating tumor cell (CTC) clusters play a pivotal role in tumor metastasis.
Dan Li, Yingli Wang, Chang Li, Qiu Wang, Bingjun Sun, Haotian Zhang, Zhonggui He, Jin Sun   +7 more
doaj   +2 more sources

High throughput, label-free isolation of circulating tumor cell clusters in meshed microwells [PDF]

Nature Communications, 2022
Metastatic CTC clusters remain relatively unexplored due to the lack of optimized and practical technologies for their detection. Here the authors report Cluster-Wells to isolate CTC clusters in whole blood; they show this allows viable cluster retrieval
Mert Boya, Tevhide Ozkaya-Ahmadov, Brandi E. Swain, Chia-Heng Chu, Norh Asmare, Ozgun Civelekoglu, Ruxiu Liu, Dohwan Lee, Sherry Tobia, Shweta Biliya, L. DeEtte McDonald, Bassel Nazha, Omer Kucuk, Martin G. Sanda, Benedict B. Benigno, Carlos S. Moreno, Mehmet A. Bilen, John F. McDonald, A. Fatih Sarioglu   +18 more
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Label-free flow cytometry of rare circulating tumor cell clusters in whole blood [PDF]

Scientific Reports, 2022
Circulating tumor cell clusters (CTCCs) are rare cellular events found in the blood stream of metastatic tumor patients. Despite their scarcity, they represent an increased risk for metastasis.
Nilay Vora, Prashant Shekhar, Michael Esmail, Abani Patra, Irene Georgakoudi   +4 more
doaj   +2 more sources

In Vitro Model-Systems to Understand the Biology and Clinical Significance of Circulating Tumor Cell Clusters [PDF]

Frontiers in Oncology, 2018
The isolation of clusters of circulating tumor cells (CTCs) from cancer patients has recently challenged the accepted view that the initiation of secondary tumors during metastasis involves the dissemination of individual cancer cells.
Alexander N. May, Bryan D. Crawford, Aurora M. Nedelcu   +2 more
doaj   +2 more sources

Systematic optimization and evaluation of culture conditions for the construction of circulating tumor cell clusters using breast cancer cell lines [PDF]

BMC Cancer
Background Circulating tumor cell (CTC) clusters play a critical role in carcinoma metastasis. However, the rarity of CTC clusters and the limitations of capture techniques have retarded the research progress.
Jueyao Zou, Qiong Chen, Yong He, Yanhong Pan, Han Zhao, Junfeng Shi, Zhonghong Wei, Suyun Yu, Yang Zhao, Xin Han, Yin Lu, Wenxing Chen   +11 more
doaj   +2 more sources

Hirudin suppresses hematogenous metastasis by targeting desmosome junction transition in circulating tumor cell clusters via HIF-1α–DSG2 signaling [PDF]

Experimental and Molecular Medicine
s Circulating tumor cell (CTC) clusters, key in metastasis, rely on intercellular junctions for stability. However, the specific mechanisms governing intercellular connections within CTC clusters and the strategy targeting intercellular junctions to ...
Jueyao Zou, Junfeng Shi, Qiong Chen, Ziyan Zhu, Tongyao Hu, Zhengyu Zhang, Zhiqiang Pan, Fei Xu, Yong Zhu, Yuanyuan Wu, Yang Zhao, Aiyun Wang, Yin Lu, Yanhong Pan, Wenxing Chen   +14 more
doaj   +2 more sources

c-MET Inhibition Reverses the Osimertinib Resistance in Lung Circulating Tumor Cell Clusters and Suppresses Metastasis [PDF]

Biological Procedures Online
Background Circulating tumor cells (CTCs) serve as the “seeds” of tumor metastasis, and the clustering of CTCs is critically associated with tumor metastasis and the mortality of lung cancer patients.
Zhipeng Zhang, Xinyi Lu, Jianhui Tian, Jiaxuan Li, Shihui Liu, Jiajun Liu, Bin Luo, Jialiang Yao, Yao Liu, Yanhong Wang, Wang Yao, Yun Yang, Wenji Shangguan, Zujun Que   +13 more
doaj   +2 more sources