Results 1 to 10 of about 315,874 (296)

Novel approaches in cancer management with circulating tumor cell clusters [PDF]

Journal of Science: Advanced Materials and Devices, 2019
© 2019 The Authors Tumor metastasis is responsible for the vast majority of cancer-associated morbidities and mortalities. Recent studies have disclosed the higher metastatic potential of circulating tumor cell (CTC) clusters than single CTCs.
Firoozabadi, B, Kashaninejad, N, Moshksayan, K, Nguyen, NT, Rostami, P, Saidi, MS   +5 more
core   +7 more sources

Dynamic Glycoprotein Hyposialylation Promotes Chemotherapy Evasion and Metastatic Seeding of Quiescent Circulating Tumor Cell Clusters in Breast Cancer [PDF]

Cancer Discov, 2023
In breast cancer, chemotherapy evasion is coupled to loss of glycosylation (sialylation), cellular quiescence, cluster formation of circulating tumor cells, and metastasis, with anti-PODXL–targeting approaches blocking these effects.
Nurmaa K Dashzeveg, Yuzhi Jia, Youbin Zhang, L. Gerratana, Priyam Patel, A. Shajahan, Tsogbadrakh Dandar, Erika K Ramos, Hannah Almubarak, Valery Adorno-Cruz, Rokana Taftaf, Emma J Schuster, D. Scholten, Michael T. Sokolowski, C. Reduzzi, Lamiaa El-Shennawy, Andrew D Hoffmann, M. Manai, Qiang Zhang, P. D’Amico, P. Azadi, K. Colley, L. Platanias, Ami N. Shah, William J. Gradishar, M. Cristofanilli, W. Muller, B. Cobb, Huiping Liu   +28 more
semanticscholar   +2 more sources

Quantifying cancer epithelial-mesenchymal plasticity and its association with stemness and immune response [PDF]

arXiv, 2019
Cancer cells can acquire a spectrum of stable hybrid epithelial/mesenchymal (E/M) states during epithelial-mesenchymal transition (EMT). Cells in these hybrid E/M phenotypes often combine epithelial and mesenchymal features and tend to migrate collectively commonly as small clusters.
Bocci, Federico, Deng, Youyuan, Jia, Dongya, Jolly, Mohit Kumar, Levine, Herbert, Li, Xuefei, Onuchic, Jose N., Tripathi, Shubham   +7 more
arxiv   +3 more sources

PillarX: A Microfluidic Device to Profile Circulating Tumor Cell Clusters Based on Geometry, Deformability, and Epithelial State.

Small, 2022
Circulating tumor cell (CTC) clusters are associated with increased metastatic potential and worse patient prognosis, but are rare, difficult to count, and poorly characterized biophysically.
B. Green, Margherita Marazzini, B. Hershey, Amir Fardin, Qingsen Li, Zongjie Wang, G. Giangreco, F. Pisati, S. Marchesi, Andrea Disanza, E. Frittoli, Emanuele Martini, S. Magni, G. Beznoussenko, Claudio Vernieri, Riccardo Lobefaro, D. Parazzoli, P. Maiuri, K. Havas, Mahmoud Labib, S. Sigismund, P. P. D. Fiore, R. Gunby, S. Kelley, G. Scita   +24 more
semanticscholar   +2 more sources

Circulating Tumor Cells Enumeration from the Portal Vein for Risk Stratification in Early Pancreatic Cancer Patients [PDF]

, 2021
[Simple Summary] Effective biomarkers are needed to enable personalized medicine for pancreatic cancer patients. This study analyzes the prognostic value, in early pancreatic cancer, of circulating tumor cells and clusters from the central venous ...
Almoguera, Francisco, Bernal, Carmen, Calero-Castro, Francisco José, Cepeda-Franco, Carmen, Denninghoff, Valeria, Gallego, Inmaculada, García-Fernandez, Francisco José, Gómez-Bravo, Miguel A., Macher, Hada C., Marín, Luis, Padillo-Ruíz, Javier, Pereira, Sheila, Romero, Manuel, Serrano, María José, Suárez, Gonzalo, Tinoco, José, Villanueva, Paula, Álamo-Martinez, José M.   +17 more
core   +1 more source

Deep Learning-Enabled, Detection of Rare Circulating Tumor Cell Clusters in Whole Blood Using Label-free, Flow Cytometry

bioRxiv, 2023
Metastatic tumors have poor prognoses for progression-free and overall survival for all cancer patients. Rare circulating tumor cells (CTCs) and rarer circulating tumor cell clusters (CTCCs) are potential biomarkers of metastatic growth, with CTCCs ...
Nilay Vora, Prashant Shekar, M. Esmail, Abani Patra, I. Georgakoudi   +4 more
semanticscholar   +1 more source

Emerging Technologies for Cancer Research: Towards Personalized Medicine with Microfluidic Platforms and 3D Tumor Models [PDF]

Current Medicinal Chemistry, 2018, 2021
In the present review, we describe three hot topics in cancer research such as circulating tumor cells, exosomes, and 3D environment models. The first section is dedicated to microfluidic platforms for detecting circulating tumor cells, including both affinity based methods that take advantage of antibodies and aptamers, and label free approaches ...
arxiv   +1 more source

A lab-on-a-disc platform enables serial monitoring of individual CTCs associated with tumor progression during EGFR-targeted therapy for patients with NSCLC [PDF]

, 2020
Rationale: Unlike traditional biopsy, liquid biopsy, which is a largely non-invasive diagnostic and monitoring tool, can be performed more frequently to better track tumors and mutations over time and to validate the efficiency of a cancer treatment ...
Cho, Yoon-Kyoung, Jeong, Hyoung-oh, Kim, Gwang Ha, Kim, Mi-Hyun, Lee, Kyusang, Lee, Semin, Lim, Minji, Lowe, Alarice C., Park, Hee Chul, Park, Juhee   +9 more
core   +1 more source

Linear-array-based photoacoustic tomography for label-free high throughput detection and quantification of circulating melanoma tumor cell clusters [PDF]

, 2017
Circulating tumor cell (CTC) clusters arise from multicellular grouping in the primary tumor and elevate the metastatic potential by 23 to 50 fold compared to single CTCs.
Hai, Pengfei, Li, Yang, Ma, Jun, Shao, Jin-Yu, Wang, Lihong V., Zhang, Ruiying, Zhou, Yong   +6 more
core   +4 more sources

Algorithmic asymptotic analysis: extending the arsenal of cancer immunology modeling [PDF]

Journal of Theoretical Biology Volume 534, 7 February 2022, 110975, 2021
The recent advances in cancer immunotherapy boosted the development of tumor-immune system models aiming to provide mechanistic understanding and indicate more efficient treatment regimes. However, the complexity of such models, their multi-scale dynamics and their overparameterized character renders them inaccessible for wide utilization. In this work,
arxiv   +1 more source