Results 11 to 20 of about 39,675 (281)

Single Cell Analysis of Inertial Migration by Circulating Tumor Cells and Clusters

Micromachines, 2023
Single-cell analysis provides a wealth of information regarding the molecular landscape of the tumor cells responding to extracellular stimulations, which has greatly advanced the research in cancer biology.
Jian Zhou, Alexandra Vorobyeva, Qiyue Luan, Ian Papautsky   +3 more
doaj   +3 more sources

Novel approaches in cancer management with circulating tumor cell clusters

Journal of Science: Advanced Materials and Devices, 2019
Tumor metastasis is responsible for the vast majority of cancer-associated morbidities and mortalities. Recent studies have disclosed the higher metastatic potential of circulating tumor cell (CTC) clusters than single CTCs.
Peyman Rostami, Navid Kashaninejad, Khashayar Moshksayan, Mohammad Said Saidi, Bahar Firoozabadi, Nam-Trung Nguyen   +5 more
doaj   +3 more sources

Circulating tumor cell clusters and circulating tumor cell-derived explant models as a tool for treatment response

BioTechniques, 2020
Biderahalli Kruthika Prasanna, Ajay Balakrishnan, Prashant Kumar   +2 more
doaj   +3 more sources

Clinical significance and heterogeneity of circulating tumor cells and clusters in breast cancer subtypes [PDF]

PeerJ
The marked heterogeneity of breast cancer results in substantial variations in clinical characteristics, metastatic patterns, and prognosis across molecular subtypes.
LiangYu Hao, Lixiang Zheng
doaj   +3 more sources

Gravity-based microfiltration reveals unexpected prevalence of circulating tumor cell clusters in ovarian and colorectal cancer [PDF]

Communications Medicine
Background Circulating tumor cells (CTCs) are rare (a few cells per milliliter of blood) and mostly isolated as single-cell CTCs (scCTCs). CTC clusters (cCTCs), even rarer, are of growing interest, notably because of their higher metastatic potential ...
Anne Meunier, Javier Alejandro Hernández-Castro, Nicholas Chahley, Laudine Communal, Sara Kheireddine, Newsha Koushki, Nadia Davoudvandi, Sara Al Habyan, Benjamin Péant, Anthoula Lazaris, Andy Ng, Teodor Veres, Luke McCaffrey, Diane Provencher, Peter Metrakos, Anne-Marie Mes-Masson, David Juncker   +16 more
doaj   +2 more sources

Deep learning-enabled detection of rare circulating tumor cell clusters in whole blood using label-free, flow cytometry.

Lab Chip
Vora N, Shekar P, Hanulia T, Esmail M, Patra A, Georgakoudi I.   +5 more
europepmc   +3 more sources

Circulating Tumor Cell Clusters in Patients with Metastatic Breast Cancer: a SWOG S0500 Translational Medicine Study. [PDF]

Clin Cancer Res, 2019
Paoletti C, Miao J, Dolce EM, Darga EP, Repollet MI, Doyle GV, Gralow JR, Hortobagyi GN, Smerage JB, Barlow WE, Hayes DF.   +10 more
europepmc   +3 more sources

Intratumor Heterogeneity and Circulating Tumor Cell Clusters [PDF]

Molecular Biology and Evolution, 2017
SummaryGenetic diversity plays a central role in tumor progression, metastasis, and resistance to treatment. Experiments are shedding light on this diversity at ever finer scales, but interpretation is challenging. Using recent progress in numerical models, we simulate macroscopic tumors to investigate the interplay between growth dynamics, microscopic
Zafarali Ahmed, Simon Gravel
openalex   +4 more sources

Metastasis Stemming from Circulating Tumor Cell Clusters. [PDF]

Trends Cell Biol, 2019
Circulating tumor cell (CTC) clusters have an enhanced capacity to initiate metastases, compared with single cells, but it is unclear how they gain such advantage. A recent study by Gkountela etal. (Cell 2019;176:98-112) links the physical state of clusters with increased accessibility of stem cell-related transcription factors, providing novel ...
Yu M.
europepmc   +4 more sources

Circulating Tumor Cell Clusters: United We Stand Divided We Fall. [PDF]

Int J Mol Sci, 2020
The presence of circulating tumor cells (CTCs) and CTC clusters, also known as tumor microemboli, in biological fluids has long been described. Intensive research on single CTCs has made a significant contribution in understanding tumor invasion, metastasis tropism, and intra-tumor heterogeneity.
Amintas S, Bedel A, Moreau-Gaudry F, Boutin J, Buscail L, Merlio JP, Vendrely V, Dabernat S, Buscail E.   +8 more
europepmc   +6 more sources