Results 21 to 30 of about 39,675 (281)

Better together: circulating tumor cell clustering in metastatic cancer [PDF]

Trends in Cancer, 2021
Circulating tumor cells (CTCs) are vital components of liquid biopsies for diagnosis of residual cancer, monitoring of therapy response, and prognosis of recurrence. Scientific dogma focuses on metastasis mediated by single CTCs, but advancement of CTC detection technologies has elucidated multicellular CTC clusters, which are associated with ...
Schuster, Emma, Taftaf, Rokana, Reduzzi, Carolina, Albert, Mary K., Romero-Calvo, Isabel, Liu, Huiping   +5 more
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Hypoxia Triggers the Intravasation of Clustered Circulating Tumor Cells [PDF]

Cell Reports, 2020
Cell Reports, 32 (10)
Donato, Cinzia, Kunz, Leo, Castro-Giner, Francesc, Paasinen-Sohns, Aino, Strittmatter, Karin, Szczerba, Barbara Maria, Scherrer, Ramona, Di Maggio, Nunzia, Heusermann, Wolf, Biehlmaier, Oliver, Beisel, Christian, Vetter, Marcus, Rochlitz, Christoph, Weber, Walter Paul, Banfi, Andrea, Schroeder, Timm, Aceto, Nicola   +16 more
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Single-cell resolution characterization of circulating tumor cell clusters

, 2019
Metastatic dissemination is responsible for more than 90% of cancer-related deaths. However, the molecular features underlying the metastatic process are largely uncharacterized. Cancer cells that leave a primary tumor and enter the bloodstream are referred to as circulating tumor cells (CTCs). While extraordinarily rare compared to normal blood cells,
Barbara M. Szczerba
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Circulating Tumor Cell Clustering Shapes DNA Methylation to Enable Metastasis Seeding [PDF]

Cell, 2019
The ability of circulating tumor cells (CTCs) to form clusters has been linked to increased metastatic potential. Yet biological features and vulnerabilities of CTC clusters remain largely unknown. Here, we profile the DNA methylation landscape of single CTCs and CTC clusters from breast cancer patients and mouse models on a genome-wide scale.
Sofia Gkountela, Francesc Castro-Giner, Barbara M. Szczerba, Marcus Vetter, Julia Landin, Ramona Scherrer, Ilona Krol, Manuel C. Scheidmann, Christian Beisel, Christian U. Stirnimann, Christian Kurzeder, Viola Heinzelmann‐Schwarz, Christoph Rochlitz, William P. Weber, Nicola Aceto   +14 more
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Algorithm to identify circulating tumor cell clusters using in vivo flow cytometer [PDF]

Journal of Innovative Optical Health Sciences, 2018
Recent studies in oncology have addressed the importance of detecting circulating tumor cell clusters because circulating tumor cell clusters might survive and metastasize more easily than single circulating tumor cells.
Kai Pang, Dan Wei, Pengfei Hai, Zhangru Yang, Xiaofu Weng, Xunbin Wei   +5 more
doaj   +1 more source

Phylogenetic inference reveals clonal heterogeneity in circulating tumor cell clusters. [PDF]

Nat Genet
Abstract Circulating tumor cell (CTC) clusters are highly efficient metastatic seeds in various cancers. Yet, their genetic heterogeneity and clonal architecture is poorly characterized. Using whole-exome sequencing coupled with phylogenetic inference from CTC clusters of patients with breast and prostate cancer, as well as mouse cancer ...
Gremmelspacher D, Gawron J, Szczerba BM, Jahn K, Castro-Giner F, Kuipers J, Singer J, Marass F, Gvozdenovic A, Budinjas S, Pueschel H, Rentsch CA, Zippelius A, Heinzelmann-Schwarz V, Kurzeder C, Weber WP, Rochlitz C, Vetter M, Beerenwinkel N, Aceto N.   +19 more
europepmc   +3 more sources

Clusters of circulating tumor cells traverse capillary-sized vessels [PDF]

Proceedings of the National Academy of Sciences, 2016
Significance Metastasis is responsible for 90% of cancer-related deaths and is driven by tumor cells circulating in blood. However, it is believed that only individual tumor cells can reach distant organs because multicellular clusters are too large to pass through narrow capillaries.
Au, SH, Storey, BD, Moore, JC, Tang, Q, Chen, Y, Javaid, S, Sarioglu, AF, Sullivan, R, Madden, MW, O’Keefe, R, Haber, DA, Maheswaran, S, Langenau, DM, Stott, SL, Toner, M   +14 more
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Mitotic arrest affects clustering of tumor cells

Cell Division, 2021
Background Cancer cell aggregation is a key process involved in the formation of tumor cell clusters. It has recently been shown that clusters of circulating tumor cells (CTCs) have an increased metastatic potential compared to isolated circulating tumor
Julia Bonnet, Lise Rigal, Odile Mondesert, Renaud Morin, Gaëlle Corsaut, Mathieu Vigneau, Bernard Ducommun, Valérie Lobjois   +7 more
doaj   +1 more source

Circulating tumor cell clusters are oligoclonal precursors of breast cancer metastasis. [PDF]

Cell, 2014
Circulating tumor cell clusters (CTC clusters) are present in the blood of patients with cancer but their contribution to metastasis is not well defined. Using mouse models with tagged mammary tumors, we demonstrate that CTC clusters arise from oligoclonal tumor cell groupings and not from intravascular aggregation events.
Aceto N, Bardia A, Miyamoto DT, Donaldson MC, Wittner BS, Spencer JA, Yu M, Pely A, Engstrom A, Zhu H, Brannigan BW, Kapur R, Stott SL, Shioda T, Ramaswamy S, Ting DT, Lin CP, Toner M, Haber DA, Maheswaran S.   +19 more
europepmc   +6 more sources

Tumor-derived circulating endothelial cell clusters in colorectal cancer [PDF]

Science Translational Medicine, 2016
A population of cell clusters circulating in cancer patients consist of tumor-derived endothelial cells reflecting features of the tumor vasculature.
Cima, Igor, Kong, Say Li, Sengupta, Debarka, Tan, Iain B, Phyo, Wai Min, Lee, Daniel, Hu, Min, Iliescu, Ciprian, Alexander, Irina, Goh, Wei Lin, Rahmani, Mehran, Suhaimi, Nur-Afidah Mohamed, Vo, Jess H, Tai, Joyce A, Tan, Joanna H, Chua, Clarinda, Ten, Rachel, Lim, Wan Jun, Chew, Min Hoe, Hauser, Charlotte A E, van Dam, Rob M, Lim, Wei-Yen, Prabhakar, Shyam, Lim, Bing, Koh, Poh Koon, Robson, Paul, Ying, Jackie Y, Hillmer, Axel M, Tan, Min-Han   +28 more
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