Results 31 to 40 of about 39,675 (281)

Circulating tumor cell clusters: Insights into tumour dissemination and metastasis [PDF]

open access: yesExpert Review of Molecular Diagnostics, 2020
Introduction: Metastasis results in more than 90% of cancer-related deaths globally. The process is thought to be facilitated by metastatic precursor cells, commonly termed circulating tumor cells (CTCs). CTCs can exist as single cells or cell clusters and travel through the lymphovasculature to distant organs where they can form overt metastasis ...
Sayuri Herath   +6 more
openaire   +3 more sources

Bring along your friends: Homotypic and heterotypic circulating tumor cell clustering to accelerate metastasis

open access: yesBiomedical Journal, 2020
Metastasis formation is a hallmark of invasive cancers and it is achieved through the shedding of circulating tumor cells (CTCs) from the primary site into the blood circulation.
Nicola Aceto
doaj   +1 more source

The Effect of Lung Resection for NSCLC on Circulating Immune Cells: A Pilot Study

open access: yesCurrent Oncology, 2023
This pilot study sought to evaluate the circulating levels of immune cells, particularly regulatory T-cell (Treg) subsets, before and after lung resection for non-small cell lung cancer.
Joseph D. Phillips   +10 more
doaj   +1 more source

ICAM1 initiates CTC cluster formation and trans-endothelial migration in lung metastasis of breast cancer

open access: yesNature Communications, 2021
Circulating tumor cell (CTC) clusters are more efficient at mediating metastasis as compared to single cells and are associated with poor prognosis in breast cancer.
Rokana Taftaf   +21 more
doaj   +1 more source

Proportion of circulating tumor cell clusters increases during cancer metastasis [PDF]

open access: yesCytometry Part A, 2016
AbstractCirculating tumor cell (CTC) clusters are found among CTCs and show significantly greater potential for an important role in cancer metastasis than single CTCs, which have been traditionally believed as the majority of CTCs. The accurate proportion and dynamics of CTC clusters remain unclear due to the fact that CTCs in blood flow are very ...
Yuanzhen, Suo   +6 more
openaire   +2 more sources

The Presence of Circulating Tumor Cell Cluster Characterizes an Aggressive Hepatocellular Carcinoma Subtype

open access: yesFrontiers in Oncology, 2021
BackgroundGrowing evidence suggests that circulating tumor cell (CTC) clusters may be an important factor in the metastatic process, but their role in hepatocellular carcinoma (HCC) remains unclear.
Jing-Jing Yu   +9 more
doaj   +1 more source

Clusters of circulating tumor cells: A biophysical and technological perspective [PDF]

open access: yesCurrent Opinion in Biomedical Engineering, 2017
The vast majority of cancer associated deaths result from metastasis, yet the behaviors of its most potent cellular driver, circulating tumor cell clusters, are only beginning to be revealed. This review highlights recent advances to our understanding of tumor cell clusters with emphasis on enabling technologies.
Sam H, Au   +5 more
openaire   +2 more sources

Microfluidic techniques for isolation, formation, and characterization of circulating tumor cells and clusters

open access: yesAPL Bioengineering, 2022
Circulating tumor cell (CTC) clusters that are shed from the primary tumor into the bloodstream are associated with a poor prognosis, elevated metastatic potential, higher proliferation rate, and distinct molecular features compared to single CTCs ...
Celine Macaraniag   +3 more
doaj   +1 more source

Circulating tumor biomarkers in early-stage breast cancer: characteristics, detection, and clinical developments

open access: yesFrontiers in Oncology, 2023
Breast cancer is the most common form of cancer in women, contributing to high rates of morbidity and mortality owing to the ability of these tumors to metastasize via the vascular system even in the early stages of progression. While ultrasonography and
Jie Qiu   +4 more
doaj   +1 more source

Circulating tumor cell clusters: What we know and what we expect (Review). [PDF]

open access: yesInt J Oncol, 2016
The major cause of cancer-associated mortality is tumor metastasis, a disease that is far from understood. Many studies have observed circulating tumor cells (CTCs) in patients' circulation systems, and a few latest investigations showed that CTC clusters have a potentially high capacity of metastasis. The capture and analysis of CTC clusters offer new
Hong Y, Fang F, Zhang Q.
europepmc   +4 more sources

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